scholarly journals Biliary excretion and enterohepatic circulation of thienorphine and its glucuronide conjugate in rats

2012 ◽  
Vol 2 (2) ◽  
pp. 174-180 ◽  
Author(s):  
Jingting Deng ◽  
Xiaomei Zhuang ◽  
Guolin Shen ◽  
Hua Li ◽  
Zehui Gong
Keyword(s):  
Biliary Excretion ◽  
Enterohepatic Circulation ◽  
Glucuronide Conjugate

Intact biliary excretion of gastrically administered prostaglandin F2 alpha in rats: developmental differences

1987 ◽  
Vol 253 (6) ◽  
pp. G787-G792
Author(s):  
A. D. Bedrick ◽  
M. A. Wells ◽  
D. L. Ford ◽  
O. Koldovsky
Keyword(s):  
Gastrointestinal Tract ◽  
Bile Duct ◽  
Biliary Excretion ◽  
Enterohepatic Circulation ◽  
Developmental Differences ◽  
Orogastric Tube ◽  
Prostaglandin F2 Alpha ◽  
Age Related ◽  
Weanling Rats

Tritium-labeled prostaglandin F2 alpha was administered via orogastric tube to bile duct-cannulated suckling and weanling rats to determine if maturational differences were present in the biliary excretion of prostaglandin F2 alpha and metabolites. Animals were killed 2 h after radioactivity administration. Characterization of radioactivity present in bile revealed age-related differences in biliary prostaglandin F2 alpha excretion. Suckling rats had a greater proportion of radioactivity migrating in chromatographic regions of greater polarity than prostaglandin F2 alpha. Compared with the weanling, a significantly greater amount of radioactivity cochromatographed with intact, unmetabolized prostaglandin F2 alpha (33.08 +/- 1.99 vs. 21.38 +/- 1.46). These results indicate that orogastrically administered prostaglandin F2 alpha can be absorbed from the gastrointestinal tract, transported to the liver, and subsequently excreted into bile and detected in an unmetabolized form in suckling and weanling rats. The enterohepatic circulation of milk-derived prostaglandin present in bile may contribute to the overall content of intestinal prostaglandins.

Biliary excretion of [3H]-25-hydroxyvitamin D3 in the vitamin D-depleted rat

1982 ◽  
Vol 242 (5) ◽  
pp. G522-G532 ◽  
Author(s):  
M. Gascon-Barre
Keyword(s):  
Vitamin D ◽  
Biliary Excretion ◽  
Enterohepatic Circulation ◽  
Dose Range ◽  
Systemic Circulation ◽  
The Body ◽  
Female Rats ◽  
Detoxification Mechanism ◽  
Rate Limiting ◽  
Intraduodenal Administration

The biliary excretion of [3H]-25-hydroxyvitamin D3 ([3H]25(OH)D3) was studied in vitamin D-depleted female rats over a 3-h period after intravenous or intraduodenal administration of intact [3H]25(OH)D3 and after the intraduodenal readministration of the [3H]25(OH)D3-derived biliary material. In each group four doses of 25(OH)D3 were administered (0.25, 2.5, 25, and 250 nmol/100 g). Over the dose range studied, the biliary excretion of [3H]25(OH)D3 could not be saturated, indicating that the biliary excretion of 25(OH)D3 is a reliable detoxification mechanism in circumstances of 25(OH)D3 intoxication. Analysis of plasma, liver, and bile suggests that the canalicular membrane seems to be rate limiting in the biliary excretion of 25(OH)D3. The intraduodenal administration of biliary excretion compounds derived from [3H]25(OH)D3 showed that they are efficiently reexcreted in newly secreted bile, confirming the existence of an enterohepatic circulation for 25(OH)D3. In this group of animals, however, the plasma analysis indicates that these compounds reach the systemic circulation in insignificant quantities, suggesting that the enterohepatic circulation probably plays a limited role in the body 25(OH)D3 economy.

Biliary excretion, metabolism and enterohepatic circulation of buprenorphine

Xenobiotica ◽  
1981 ◽  
Vol 11 (3) ◽  
pp. 189-196 ◽  
Author(s):  
D. Brewster ◽  
M. J. Humphrey ◽  
M. A. McLeavy
Keyword(s):  
Biliary Excretion ◽  
Enterohepatic Circulation

Biliary excretion and enterohepatic circulation of paracetamol in the rat

Xenobiotica ◽  
1983 ◽  
Vol 13 (10) ◽  
pp. 591-596 ◽  
Author(s):  
C. P. Siegers ◽  
K. Rozman ◽  
C. D. Klaassen
Keyword(s):  
Biliary Excretion ◽  
Enterohepatic Circulation

Biliary excretion and enterohepatic circulation of estrone and estriol in rodents

1967 ◽  
Vol 213 (5) ◽  
pp. 1138-1142 ◽  
Author(s):  
AA Sandberg ◽  
RY Kirdani ◽  
N Back ◽  
P Weyman ◽  
Slaunwhite WR
Keyword(s):  
Biliary Excretion ◽  
Enterohepatic Circulation

Studies of the absorption and enterohepatic circulation of 7,12-dimethylbenz[a]anthracene in the rat

1983 ◽  
Vol 61 (11) ◽  
pp. 1368-1373 ◽  
Author(s):  
J. M. Laher ◽  
G. A. Chernenko ◽  
J. A. Barrowman
Keyword(s):  
Biliary Excretion ◽  
Plasma Levels ◽  
Enterohepatic Circulation ◽  
Medium Chain Triglyceride ◽  
Systemic Availability ◽  
Safflower Oil ◽  
Medium Chain ◽  
Physiological Conditions ◽  
Long Chain ◽  
Long Chain Triglyceride

This study was undertaken to examine intraluminal factors which might alter the bioavailability of an orally ingested hydrocarbon carcinogen, 7,12-dimethylbenz[a]anthracene, and to assess the extent of its enterohepatic circulation. Rats with biliary and duodenal fistulae were administered radiolabelled hydrocarbon dissolved in olive oil, safflower oil, or medium-chain triglyceride only or with exogenous bile. Subsequent biliary excretion and plasma levels of radiolabel were monitored. Luminal bile significantly enhanced biliary recovery of radiolabel following instillation in both long-chain triglyceride vehicles, but did not affect the recovery from the medium-chain oil. In the presence of luminal bile, plasma levels and biliary recovery of radiolabel using the medium-chain triglyceride were significantly less than with either long-chain triglyceride. Following intraduodenal infusions of the radiolabelled biliary products of the carcinogen, 33% of the administered radiolabel was subsequently reexcreted in the bile within 24 h. This study, therefore, demonstrates that, while bile is not absolutely necessary for the uptake of this orally ingested hydrocarbon carcinogen, it significantly facilitates absorption from a long-chain triglyceride vehicle. Under physiological conditions, a long-chain triglyceride vehicle will provide greater systemic availability than a medium-chain vehicle for the hydrocarbon, which then undergoes extensive biliary excretion and recycling.

The biliary excretion and enterohepatic circulation of benzo (a)pyrene and its metabolites in the rat

1981 ◽  
Vol 30 (9) ◽  
pp. 937-944 ◽  
Author(s):  
James K. Chipman ◽  
Paul C. Hirom ◽  
Graham S. Frost ◽  
Peter Millburn
Keyword(s):  
Biliary Excretion ◽  
Enterohepatic Circulation
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