Stimuli responsive nanoplatform with mitochondria-specific multiple model therapeutics for effective tumor treatment

2020 ◽  
Vol 21 ◽  
pp. 100883
Author(s):  
Ronghua Jin ◽  
Qiao Wang ◽  
Geng Dou ◽  
Yongkang Bai ◽  
Shiyu Liu ◽  
...  
Keyword(s):  
Multiple Model ◽  
Stimuli Responsive ◽  
Tumor Treatment

A tumor-targeted nanoplatform with stimuli-responsive cascaded activities for multiple model tumor therapy

2020 ◽  
Vol 8 (7) ◽  
pp. 1865-1874 ◽  
Author(s):  
Ronghua Jin ◽  
Jirong Xie ◽  
Xiaoshan Yang ◽  
Yu Tian ◽  
Pingyun Yuan ◽  
...  
Keyword(s):  
Low Temperature ◽  
Photothermal Therapy ◽  
Tumor Therapy ◽  
Drug Efflux ◽  
Multiple Model ◽  
Stimuli Responsive ◽  
Tumor Treatment ◽  
Model Tumor

A rambutan-like nanocomplex was designed to achieve low-drug-efflux chemotherapy and low-temperature photothermal therapy for effective and accurate tumor treatment.

scholarly journals Stimuli-responsive magnetic nanohybrids for triggered drug release and potential tumor treatment via hyperthermia

2013 ◽  
Vol 172 (1) ◽  
pp. e39 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Stephane Mornet ◽  
Christine Jerome ◽  
Etienne Duguet
Keyword(s):  
Drug Release ◽  
Stimuli Responsive ◽  
Tumor Treatment ◽  
Triggered Drug Release ◽  
Magnetic Nanohybrids

scholarly journals DNA Based and Stimuli-Responsive Smart Nanocarrier for Diagnosis and Treatment of Cancer: Applications and Challenges

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3396
Author(s):  
Fakhara Sabir ◽  
Mahira Zeeshan ◽  
Ushna Laraib ◽  
Mahmood Barani ◽  
Abbas Rahdar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Rapid Development ◽  
Drug Efficacy ◽  
Diagnosis And Treatment ◽  
Dna Nanostructures ◽  
Stimuli Responsive ◽  
Tumor Treatment ◽  
Dna Nanostructure ◽  
Treatment And Diagnosis ◽  
Final Disposition

The rapid development of multidrug co-delivery and nano-medicines has made spontaneous progress in tumor treatment and diagnosis. DNA is a unique biological molecule that can be tailored and molded into various nanostructures. The addition of ligands or stimuli-responsive elements enables DNA nanostructures to mediate highly targeted drug delivery to the cancer cells. Smart DNA nanostructures, owing to their various shapes, sizes, geometry, sequences, and characteristics, have various modes of cellular internalization and final disposition. On the other hand, functionalized DNA nanocarriers have specific receptor-mediated uptake, and most of these ligand anchored nanostructures able to escape lysosomal degradation. DNA-based and stimuli responsive nano-carrier systems are the latest advancement in cancer targeting. The data exploration from various studies demonstrated that the DNA nanostructure and stimuli responsive drug delivery systems are perfect tools to overcome the problems existing in the cancer treatment including toxicity and compromised drug efficacy. In this light, the review summarized the insights about various types of DNA nanostructures and stimuli responsive nanocarrier systems applications for diagnosis and treatment of cancer.

A self-assembly and stimuli-responsive fusion gelonin delivery system for tumor treatment

2020 ◽  
Vol 89 ◽  
pp. 409-415
Author(s):  
Quan Liu ◽  
Lu Zhang ◽  
Xiuru Ji ◽  
Meong Cheol Shin ◽  
Shuping Xie ◽  
...  
Keyword(s):  
Delivery System ◽  
Self Assembly ◽  
Stimuli Responsive ◽  
Tumor Treatment

Amino-functional polyethers: versatile, stimuli-responsive polymers

2020 ◽  
Vol 11 (24) ◽  
pp. 3940-3950 ◽  
Author(s):  
Patrick Verkoyen ◽  
Holger Frey
Keyword(s):  
Ring Opening ◽  
Review Article ◽  
Stimuli Responsive ◽  
New Class ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Amino-functional polyethers have emerged as a new class of “smart”, i.e. pH- and thermoresponsive materials. This review article summarizes the synthesis and applications of these materials, obtained from ring-opening of suitable epoxide monomers.

Minimally Invasive Approach for Wilms Tumor Treatment in a Small Child - A Case Report

Urology ◽  
2020 ◽  
Author(s):  
Alexandre Azevedo Ziomkowski ◽  
João Rafael Silva Simões Estrela ◽  
Nilo Jorge Carvalho Leão Barretto ◽  
Nilo César Leão Barretto
Keyword(s):  
Case Report ◽  
Minimally Invasive ◽  
Wilms Tumor ◽  
Small Child ◽  
Tumor Treatment ◽  
Minimally Invasive Approach ◽  
Invasive Approach

A Case of Catecholamine-Secreting Glomus Jugulare Tumor: Treatment Strategy and Perioperative Management

Skull Base ◽  
2008 ◽  
Vol 18 (S 01) ◽  
Author(s):  
Hiroaki Motegi ◽  
Shunsuke Terasaka ◽  
Shigeru Yamaguchi ◽  
Hiroyuki Kobayashi ◽  
Katsuyuki Asaoka ◽  
...  
Keyword(s):  
Treatment Strategy ◽  
Perioperative Management ◽  
Tumor Treatment ◽  
Glomus Jugulare Tumor ◽  
Glomus Jugulare

4D printing technology, modern era: A short review

2020 ◽  
pp. 92-111
Author(s):  
Khodadad Mostakim ◽  
Nahid Imtiaz Masuk ◽  
Md. Rakib Hasan ◽  
Md. Shafikul Islam
Keyword(s):  
Smart Materials ◽  
Computer Aided Design ◽  
Short Review ◽  
Stimuli Responsive ◽  
4D Printing ◽  
Space Applications ◽  
Printing Technology ◽  
Practical Applications ◽  
Biomedical Technologies ◽  
Novel Material

The advancement in 3D printing has led to the rapid growth of 4D printing technology. Adding time, as the fourth dimension, this technology ushered the potential of a massive evolution in fields of biomedical technologies, space applications, deployable structures, manufacturing industries, and so forth. This technology performs ingenious design, using smart materials to create advanced forms of the 3-D printed specimen. Improvements in Computer-aided design, additive manufacturing process, and material science engineering have ultimately favored the growth of 4-D printing innovation and revealed an effective method to gather complex 3-D structures. Contrast to all these developments, novel material is still a challenging sector. However, this short review illustrates the basic of 4D printing, summarizes the stimuli responsive materials properties, which have prominent role in the field of 4D technology. In addition, the practical applications are depicted and the potential prospect of this technology is put forward.

Synthesis of Smart Mesoporous Materials

2003 ◽  
Vol 775 ◽  
Author(s):  
G.V.Rama Rao ◽  
Qiang Fu ◽  
Linnea K. Ista ◽  
Huifang Xu ◽  
S. Balamurugan ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Mesoporous Materials ◽  
Fluorescent Dyes ◽  
Thermo Gravimetric Analysis ◽  
Molecular Transport ◽  
Solute Diffusion ◽  
Gravimetric Analysis ◽  
Stimuli Responsive ◽  
Porous Network ◽  
Hybrid Mesoporous Materials

AbstractThis study details development of hybrid mesoporous materials in which molecular transport through mesopores can be precisely controlled and reversibly modulated. Mesoporous silica materials formed by surfactant templating were modified by surface initiated atom transfer radical polymerization of poly(N-isopropyl acrylamide) (PNIPAAm) a stimuli responsive polymer (SRP) within the porous network. Thermo gravimetric analysis and FTIR spectroscopy were used to confirm the presence of PNIPAAm on the silica surface. Nitrogen porosimetry, transmission electron microscopy and X-ray diffraction analyses confirmed that polymerization occurred uniformly within the porous network. Uptake and release of fluorescent dyes from the particles was monitored by spectrofluorimetry and scanning laser confocal microscopy. Results suggest that the presence of PNIPAAm, a SRP, in the porous network can be used to modulate the transport of aqueous solutes. At low temperature, (e.g., room temperature) the PNIPAAm is hydrated and extended and inhibits transport of analytes; at higher temperatures (e.g., 50°C) it is hydrophobic and is collapsed within the pore network, thus allowing solute diffusion into or out of the mesoporous silica. The transition form hydrophilic to hydrophobic state on polymer grafted mesoporous membranes was determined by contact angle measurements. This work has implications for the development of materials for the selective control of transport of molecular solutes in a variety of applications.

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