Investigating the potential of combined growth factors delivery, from non-mulberry silk fibroin grafted poly(ɛ-caprolactone)/hydroxyapatite nanofibrous scaffold, in bone tissue engineering

2016 ◽  
Vol 5 ◽  
pp. 52-67 ◽  
Author(s):  
Promita Bhattacharjee ◽  
Deboki Naskar ◽  
Tapas K. Maiti ◽  
Debasis Bhattacharya ◽  
Subhas C. Kundu
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Nanofibrous Scaffold

Non-mulberry silk fibroin grafted PCL nanofibrous scaffold: Promising ECM for bone tissue engineering

2015 ◽  
Vol 71 ◽  
pp. 490-509 ◽  
Author(s):  
Promita Bhattacharjee ◽  
Deboki Naskar ◽  
Hae-Won Kim ◽  
Tapas K. Maiti ◽  
Debasis Bhattacharya ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Nanofibrous Scaffold

scholarly journals Scaffolds for Growth Factor Delivery as Applied to Bone Tissue Engineering

2012 ◽  
Vol 2012 ◽  
pp. 1-25 ◽  
Author(s):  
Keith A. Blackwood ◽  
Nathalie Bock ◽  
Tim R. Dargaville ◽  
Maria Ann Woodruff
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Donor Site ◽  
Structural Features ◽  
Donor Site Morbidity ◽  
Tissue Type ◽  
Specific Cell ◽  
Growth Factor Delivery

There remains a substantial shortfall in the treatment of severe skeletal injuries. The current gold standard of autologous bone grafting from the same patient has many undesirable side effects associated such as donor site morbidity. Tissue engineering seeks to offer a solution to this problem. The primary requirements for tissue-engineered scaffolds have already been well established, and many materials, such as polyesters, present themselves as potential candidates for bone defects; they have comparable structural features, but they often lack the required osteoconductivity to promote adequate bone regeneration. By combining these materials with biological growth factors, which promote the infiltration of cells into the scaffold as well as the differentiation into the specific cell and tissue type, it is possible to increase the formation of new bone. However due to the cost and potential complications associated with growth factors, controlling the rate of release is an important design consideration when developing new bone tissue engineering strategies. This paper will cover recent research in the area of encapsulation and release of growth factors within a variety of different polymeric scaffolds.

Development of silk fibroin/nanohydroxyapatite composite hydrogels for bone tissue engineering

2015 ◽  
Vol 67 ◽  
pp. 66-77 ◽  
Author(s):  
Marta Ribeiro ◽  
Mariana A. de Moraes ◽  
Marisa M. Beppu ◽  
Mónica P. Garcia ◽  
Maria H. Fernandes ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Composite Hydrogels

Osteon-mimetic 3D nanofibrous scaffold enhancing stem cell proliferation and osteogenic differentiation for bone regeneration

2022 ◽  
Author(s):  
Ting Song ◽  
Jianhua Zhou ◽  
Ming Shi ◽  
Liuyang Xuan ◽  
Huamin Jiang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Bone Tissue ◽  
Nanofibrous Scaffold ◽  
Hierarchical Microstructure ◽  
Stem Cell Proliferation

Scaffold microstructure is important for bone tissue engineering. Failure to synergistically imitate the hierarchical microstructure of bone component, such as osteon with concentric multilayers assembled by nanofibers, hindered the performance...

Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue engineering approach

2021 ◽  
Vol 17 (1) ◽  
pp. 015003
Author(s):  
Lya Piaia ◽  
Simone S Silva ◽  
Joana M Gomes ◽  
Albina R Franco ◽  
Emanuel M Fernandes ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Cellular Proliferation ◽  
Mechanical Performance ◽  
Tissue Growth ◽  
Polymeric Scaffolds ◽  
Bioactive Agents

Abstract Bone regeneration and natural repair are long-standing processes that can lead to uneven new tissue growth. By introducing scaffolds that can be autografts and/or allografts, tissue engineering provides new approaches to manage the major burdens involved in this process. Polymeric scaffolds allow the incorporation of bioactive agents that improve their biological and mechanical performance, making them suitable materials for bone regeneration solutions. The present work aimed to create chitosan/beta-tricalcium phosphate-based scaffolds coated with silk fibroin and evaluate their potential for bone tissue engineering. Results showed that the obtained scaffolds have porosities up to 86%, interconnectivity up to 96%, pore sizes in the range of 60–170 μm, and a stiffness ranging from 1 to 2 MPa. Furthermore, when cultured with MC3T3 cells, the scaffolds were able to form apatite crystals after 21 d; and they were able to support cell growth and proliferation up to 14 d of culture. Besides, cellular proliferation was higher on the scaffolds coated with silk. These outcomes further demonstrate that the developed structures are suitable candidates to enhance bone tissue engineering.

Silk Fibroin-Based Scaffold for Bone Tissue Engineering

2018 ◽  
pp. 371-387 ◽  
Author(s):  
Joo Hee Choi ◽  
Do Kyung Kim ◽  
Jeong Eun Song ◽  
Joaquim Miguel Oliveira ◽  
Rui Luis Reis ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin
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