scholarly journals Bilateral adrenalectomy in Cushing's disease: Altered long-term quality of life compared to other treatment options

2019 ◽  
Vol 80 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Pauline Sarkis ◽  
Muriel Rabilloud ◽  
Jean-Christophe Lifante ◽  
Anna Siamand ◽  
Emmanuel Jouanneau ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cushing’S Disease ◽  
Treatment Options ◽  
Bilateral Adrenalectomy ◽  
Cushing's Disease

scholarly journals MANAGEMENT OF ENDOCRINE DISEASE: The burden of Cushing's disease: clinical and health-related quality of life aspects

2012 ◽  
Vol 167 (3) ◽  
pp. 311-326 ◽  
Author(s):  
R A Feelders ◽  
S J Pulgar ◽  
A Kempel ◽  
A M Pereira
Keyword(s):  
Quality Of Life ◽  
Cushing’S Disease ◽  
Treatment Options ◽  
Current Treatment ◽  
Cushing's Disease ◽  
Health Related Quality ◽  
Time To Diagnosis ◽  
Related Quality ◽  
Health Related

ObjectiveCushing's disease (CD) is a rare endocrine disorder characterized by excess secretion of ACTH due to a pituitary adenoma. Current treatment options are limited and may pose additional risks. A literature review was conducted to assess the holistic burden of CD.DesignStudies published in English were evaluated to address questions regarding the epidemiology of CD, time to diagnosis, health-related quality of life (HRQoL), treatment outcomes, mortality, prevalence of comorbidities at diagnosis, and reversibility of comorbidities following the treatment.MethodsA two-stage literature search was performed in Medline, EMBASE, and Science Citation Index, using keywords related to the epidemiology, treatment, and outcomes of CD: i) articles published from 2000 to 2012 were identified and ii) an additional hand search (all years) was conducted on the basis of bibliography of identified articles.ResultsAt the time of diagnosis, 58–85% of patients have hypertension, 32–41% are obese, 20–47% have diabetes mellitus, 50–81% have major depression, 31–50% have osteoporosis, and 38–71% have dyslipidemia. Remission rates following transsphenoidal surgery (TSS) are high when performed by expert pituitary surgeons (rates of 65–90%), but the potential for relapse remains (rates of 5–36%). Although some complications can be partially reversed, time to reversal can take years. The HRQoL of patients with CD also remains severely compromised after remission.ConclusionsThese findings highlight the significant burden associated with CD. As current treatment options may not fully reverse the burden of chronic hypercortisolism, there is a need for both improved diagnostic tools to reduce the time to diagnosis and effective therapy, particularly a targeted medical therapy.

Quality of life after laparoscopic bilateral adrenalectomy for Cushing's disease

Surgery ◽  
2002 ◽  
Vol 132 (6) ◽  
pp. 1064-1069 ◽  
Author(s):  
Mary T. Hawn ◽  
David Cook ◽  
Clifford Deveney ◽  
Brett C. Sheppard
Keyword(s):  
Quality Of Life ◽  
Cushing’S Disease ◽  
Bilateral Adrenalectomy ◽  
Cushing's Disease

scholarly journals Cardiovascular risk in patients with Cushing’s disease – an interdisciplinary problem

2021 ◽  
Vol 17 (3) ◽  
pp. 197-202
Author(s):  
Agnieszka Jurek ◽  
◽  
Paweł Krzesiński ◽  
Grzegorz Gielerak ◽  
Beata Uziębło-Życzkowska ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cardiovascular Risk ◽  
Cushing’S Disease ◽  
Treatment Options ◽  
Pituitary Tumour ◽  
Cushing's Disease ◽  
Entire Body ◽  
Systemic Complications ◽  
Cardiovascular Assessment

Cushing’s disease is a chronic endogenous hypercortisolaemia associated with overproduction of adrenocorticotropic hormone by a pituitary adenoma, leading to multiple systemic complications that significantly increase morbidity and mortality, as well as reduce the quality of life as a result of prolonged tissue exposure to excess cortisol. Hypercortisolaemia in Cushing’s disease is associated with significant functional and constitutional disorders of the entire body. The consequences of chronic hypercortisolaemia include haemodynamic disorders associated with excessive vascular contraction and increased blood pressure, obesity, carbohydrate metabolism disorders, dyslipidaemia, and coagulopathies, which may contribute to significant cardiovascular remodelling. Cardiovascular disorders have a particular impact on long-term prognosis and quality of life in Cushing’s disease. If left untreated, Cushing’s disease significantly increases the cardiovascular risk and limits the treatment options for secondary organ complications. Cardiovascular mortality (myocardial infarction, heart failure, stroke) is several times higher in patients with Cushing’s disease than in the general population. Early diagnosis of the corticotropic pituitary tumour, as well as a thorough morphological and functional cardiovascular assessment seem essential in risk stratification. Normalisation of cortisol levels after combined neurosurgical and/or pharmacological treatment reduces mortality and the risk of cardiovascular and respiratory complications. The aim of this study is to present the complexity of clinical problems in patients with Cushing’s disease, who are in a particular need of interdisciplinary care.

scholarly journals Quality of Life in Cushing's disease: A long term issue?

2018 ◽  
Vol 79 (3) ◽  
pp. 132-137 ◽  
Author(s):  
Susan M. Webb ◽  
Alicia Santos ◽  
Eugenia Resmini ◽  
Maria-Antonia Martínez-Momblán ◽  
Luciana Martel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cushing’S Disease ◽  
Cushing's Disease

Long-term negative impact on quality of life in patients with successfully treated Cushing's disease

2004 ◽  
Vol 61 (4) ◽  
pp. 458-465 ◽  
Author(s):  
Adrian H. Heald ◽  
Sandip Ghosh ◽  
Stephanie Bray ◽  
Christine Gibson ◽  
Simon G Anderson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cushing’S Disease ◽  
Negative Impact ◽  
Cushing's Disease

scholarly journals Quality of Life in Patients after Long-Term Biochemical Cure of Cushing’s Disease

2005 ◽  
Vol 90 (6) ◽  
pp. 3279-3286 ◽  
Author(s):  
M. O. van Aken ◽  
A. M. Pereira ◽  
N. R. Biermasz ◽  
S. W. van Thiel ◽  
H. C. Hoftijzer ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Biochemical Cure

scholarly journals Cushing’s Disease – Quality of Life, Recurrence and Long-term Morbidity

2015 ◽  
Vol 11 (1) ◽  
pp. 34 ◽  
Author(s):  
Isabel Huguet ◽  
Georgia Ntali ◽  
Ashley Grossman ◽  
Niki Karavitaki ◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Recurrence Rates ◽  
Related Quality ◽  
Health Related ◽  
Acth Secreting

Cushing’s disease (CD) is a rare disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma. Chronic exposure to hypercortisolism leads to significant morbidities, which may be only partially reversible after remission of the disease, as well as to impairment of the health-related quality of life (HRQoL) and an increase in mortality. Transsphenoidal surgery (TSS) is the treatment of choice, and recurrence rates vary widely, confirming the need for lifelong follow-up. This review summarises the studies performed on HRQoL, recurrence rates and morbidities in patients who have CD.

Favorable long-term outcome of bilateral adrenalectomy in Cushing's disease

2014 ◽  
Author(s):  
Andrea Osswald ◽  
Eva Plomer ◽  
Christina Dimopoulou ◽  
Monika Milian ◽  
Rainer Blaser ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Bilateral Adrenalectomy ◽  
Cushing's Disease ◽  
Term Outcome ◽  
Long Term Outcome
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