scholarly journals Peer review report 1 on “Induction of autoimmune abdominal aortic aneurysm in pigs - A novel large animal model”

2017 ◽  
Vol 13 ◽  
pp. 184
Author(s):  
Rachel Thavayogan
Keyword(s):  
Animal Model ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Peer Review ◽  
Large Animal Model ◽  
Large Animal ◽  
Abdominal Aortic

scholarly journals Induction of autoimmune abdominal aortic aneurysm in pigs - A novel large animal model

2017 ◽  
Vol 20 ◽  
pp. 26-31 ◽  
Author(s):  
Sara Schødt Riber ◽  
Mulham Ali ◽  
Sara Hveding Bergseth ◽  
Jane Stubbe ◽  
Michael Stenger ◽  
...  
Keyword(s):  
Animal Model ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Large Animal Model ◽  
Large Animal ◽  
Abdominal Aortic

scholarly journals Optimization of the Model of Abdominal Aortic Aneurysm – Experiment in an Animal Model

2009 ◽  
Vol 46 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Jiří Moláček ◽  
Vladislav Třeška ◽  
Jiří Kobr ◽  
Bohuslav Čertík ◽  
Tomáš Skalický ◽  
...  
Keyword(s):  
Animal Model ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic

Abstract 14780: Developing a Model for Abdominal Aortic Aneurysm in Swine

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Nicholas De Leo ◽  
Atlee Melillo ◽  
Jeremy Badach ◽  
Henry Miller ◽  
Andrew Lin ◽  
...  
Keyword(s):  
Animal Model ◽  
Tensile Strength ◽  
Enzymatic Degradation ◽  
Aortic Aneurysms ◽  
Aortic Diameter ◽  
Large Animal Model ◽  
Histopathological Analysis ◽  
Large Animal ◽  
Infrarenal Aorta ◽  
Abdominal Aortic

Introduction: Abdominal aortic aneurysms (AAA) are responsible for over 150,000 deaths worldwide annually. Attempts at producing a reliable large-animal model of AAA have proven challenging. We sought to create a reproducible swine model of AAA using enzymatic degradation of the aortic wall. Methods: A total of 9 male Yorkshire swine received periadventitial injections of type 1 collagenase (23.5 mg) and porcine pancreatic elastase (500 mg) into a 4 cm segment of infrarenal aorta. Aortic diameter growth was monitored at POD 7 and 14 using ultrasound. The animals were euthanized on POD 21, and the suprarenal (control) and infrarenal (treated) aorta was harvested for analysis, after gross measurement of aortic diameter under physiologic blood pressure. Sections of control and treated aorta were used to obtain tensile strength using a tensiometer. Additional segments of the aorta were collected for histopathological analysis (H&E, elastin, alpha smooth muscle actin). PCR of matrix metalloproteinases (MMP9) was conducted. Groups were compared with paired t-tests, or ANOVA for repeated measures, where appropriate. Results: Average percent growth of aortic diameter at POD 21 for treated segments was 27% +/- 16.5% versus 4.5% +/- 4% for control tissue. The average difference in aortic growth by subject, was 26.7% [14.6%-38.8%]; (p<0.001). Aortic medial thickness was decreased in treated tissue; 235 um +/- 208 um versus 645 um +/- 191 um (p<0.0001). Quantity of both medial elastin fibers, and vascular smooth muscles cells was decreased in treated tissue; 1.8% +/- 3.16%, compared to 9.9% +/- 6.85% (p<0.0001), and 24% +/- 6.8% versus 37.4% +/- 6.9%, respectively. Tensile strength was also decreased in treated tissue; 16.7 MPa +/- 7 MPa versus 29.5 MPa +/- 10.7 MPa (p=0.0002). A 12-fold increase in expression of MMP9 mRNA was also demonstrated in aneurysmal tissue (p=0.002) Conclusion: A reproducible, large-animal model of AAA, with anatomical, histopathological, and biomechanical properties that are clinically translatable, can be achieved with extraluminal enzymatic degradation.

An Animal Model of Abdominal Aortic Aneurysm Created with Peritoneal Patch: Technique and Initial Results

2003 ◽  
Vol 26 (2) ◽  
pp. 168-176 ◽  
Author(s):  
Manuel Maynar ◽  
Zhong Qian ◽  
Javier Hernandez ◽  
Fei Sun ◽  
Carmen DeMiguel ◽  
...  
Keyword(s):  
Animal Model ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic ◽  
Patch Technique ◽  
Initial Results

scholarly journals Effect of a High-sucrose Diet on Abdominal Aortic Aneurysm Development in a Hypoperfusion-induced Animal Model

2018 ◽  
Vol 67 (5) ◽  
pp. 589-597 ◽  
Author(s):  
Chie Miyamoto ◽  
Hirona Kugo ◽  
Keisuke Hashimoto ◽  
Ayaka Sawaragi ◽  
Nobuhiro Zaima ◽  
...  
Keyword(s):  
Animal Model ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic ◽  
Sucrose Diet ◽  
Aneurysm Development ◽  
High Sucrose Diet ◽  
High Sucrose

scholarly journals Pathological Analysis of the Ruptured Vascular Wall of Hypoperfusion-induced Abdominal Aortic Aneurysm Animal Model

2017 ◽  
Vol 66 (5) ◽  
pp. 499-506 ◽  
Author(s):  
Hirona Kugo ◽  
Nobuhiro Zaima ◽  
Hiroki Tanaka ◽  
Keisuke Hashimoto ◽  
Chie Miyamoto ◽  
...  
Keyword(s):  
Animal Model ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Vascular Wall ◽  
Pathological Analysis ◽  
Abdominal Aortic
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