A study in nucleated polymerization models of protein aggregation

A Lumry−Eyring Nucleated Polymerization Model of Protein Aggregation Kinetics: 1. Aggregation with Pre-Equilibrated Unfolding

The Journal of Physical Chemistry B ◽

10.1021/jp070212j ◽

2007 ◽

Vol 111 (27) ◽

pp. 7897-7913 ◽

Cited By ~ 155

Author(s):

Jennifer M. Andrews ◽

Christopher J. Roberts

Keyword(s):

Protein Aggregation ◽

Aggregation Kinetics ◽

Nucleated Polymerization

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Lumry−Eyring Nucleated-Polymerization Model of Protein Aggregation Kinetics. 2. Competing Growth via Condensation and Chain Polymerization

The Journal of Physical Chemistry B ◽

10.1021/jp8083088 ◽

2009 ◽

Vol 113 (19) ◽

pp. 7020-7032 ◽

Cited By ~ 90

Author(s):

Yi Li ◽

Christopher J. Roberts

Keyword(s):

Protein Aggregation ◽

Aggregation Kinetics ◽

Nucleated Polymerization ◽

Chain Polymerization

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An Ultra-Structural Study of Human Melanoma in Vivo and Vitro

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100091275 ◽

1976 ◽

Vol 34 ◽

pp. 258-259

Author(s):

James R. Gaylor ◽

Fredda Schafer ◽

Robert E. Nordquist

Keyword(s):

Endoplasmic Reticulum ◽

Golgi Apparatus ◽

Protein Aggregation ◽

Structural Study ◽

Human Melanoma ◽

Protein Matrix ◽

Early Form ◽

Endoplasmic Reticulum Protein ◽

Mitochondrial Origin

Several theories on the origin of the melanosome exist. These include the Golgi origin theory, in which a tyrosinase-rich protein is "packaged" by the Golgi apparatus, thus forming the early form of the melanosome. A second theory postulates a mitochondrial origin of melanosomes. Its author contends that the melanosome is a modified mitochondria which acquires melanin during its development. A third theory states that a pre-melanosome is formed in the smooth or rough endoplasmic reticulum. Protein aggregation is suggested by one author as a possible source of the melanosome. This fourth theory postulates that the melanosome originates when the protein products of several genetic loci aggregate in the cytoplasm of the melanocyte. It is this protein matrix on which the melanin is deposited. It was with these theories in mind that this project was undertaken.

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