scholarly journals Monocytes From Spontaneously Hypertensive Rats Show Increased Store-Operated and Second Messenger-Operated Calcium Influx Mediated by Transient Receptor Potential Canonical Type 3 Channels

2007 ◽  
Vol 20 (10) ◽  
pp. 1111-1118 ◽  
Author(s):  
D LIU ◽  
A SCHOLZE ◽  
R KREUTZ ◽  
M WEHLANDVONTREBRA ◽  
W ZIDEK ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Transient Receptor Potential ◽  
Calcium Influx ◽  
Receptor Potential ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Transient Receptor Potential Canonical ◽  
Transient Receptor ◽  
Canonical Type ◽  
Type 3

scholarly journals Increased Transient Receptor Potential Canonical Type 3 Channels in Vasculature From Hypertensive Rats

Hypertension ◽  
2009 ◽  
Vol 53 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Daoyan Liu ◽  
Dachun Yang ◽  
Hongbo He ◽  
Xiaoping Chen ◽  
Tingbing Cao ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Hypertensive Rats ◽  
Transient Receptor Potential Canonical ◽  
Transient Receptor ◽  
Canonical Type ◽  
Type 3

scholarly journals Transient Receptor Potential Canonical Type 3 Channels Control the Vascular Contractility of Mouse Mesenteric Arteries

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e110413 ◽  
Author(s):  
Soo-In Yeon ◽  
Joo Young Kim ◽  
Dong-Soo Yeon ◽  
Joel Abramowitz ◽  
Lutz Birnbaumer ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Mesenteric Arteries ◽  
Transient Receptor Potential Canonical ◽  
Vascular Contractility ◽  
Transient Receptor ◽  
Canonical Type ◽  
Type 3

Transient receptor potential canonical type 3 channels and blood pressure in humans

2009 ◽  
Vol 27 (6) ◽  
pp. 1217-1223 ◽  
Author(s):  
Florian Thilo ◽  
Daniel Baumunk ◽  
Hans Krause ◽  
Mark Schrader ◽  
Kurt Miller ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Canonical ◽  
Transient Receptor ◽  
Canonical Type ◽  
Type 3

Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats

2006 ◽  
Vol 290 (1) ◽  
pp. R73-R78 ◽  
Author(s):  
Rhian M. Touyz ◽  
Ying He ◽  
Augusto C. I. Montezano ◽  
Guoying Yao ◽  
Vladimir Chubanov ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Cation Channels ◽  
Ang Ii ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Annexin 1 ◽  
Transient Receptor Potential Melastatin ◽  
Transient Receptor

Intracellular Mg2+ depletion has been implicated in vascular dysfunction in hypertension. We demonstrated that transient receptor potential melastatin 7 (TRPM7) cation channels mediate Mg2+ influx in VSMCs. Whether this plays a role in [Mg2+]i deficiency in hypertension is unclear. Here, we tested the hypothesis that downregulation of TRPM7 and its homologue TRPM6 is associated with reduced [Mg2+]i and that ANG II negatively regulates TRPM6/7 in vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR). Cultured VSMCs from Wistar Kyoto (WKY) and SHR were studied. mRNA and protein expression of TRPM6 and TRPM7 were assessed by RT-PCR and immunoblotting, respectively. Translocation of annexin-1, specific TRPM7 substrate, was measured as an index of TRPM7 activation. [Mg2+]i was determined using mag fura-2. VSMCs from WKY and SHR express TRPM6 and TRPM7. Basal TRPM6 expression was similar in WKY and SHR, but basal TRPM7 content was lower in VSMCs from SHR vs. WKY. This was associated with significantly reduced [Mg2+]i in SHR cells ( P < 0.01). ANG II time-dependently increased TRPM6 expression, with similar responses in WKY and SHR. ANG II significantly increased TRPM7 expression in WKY ( P < 0.05), but not in SHR. Annexin-1 translocation was reduced 1.5–2-fold in SHR vs. WKY. Our findings demonstrate that TRPM6 and TRPM7 are differentially regulated in VSMCs from SHR and WKY. Whereas TRPM6 is unaltered in SHR, expression of TRPM7 is blunted. This was associated with attenuated annexin-1 translocation and decreased VSMC [Mg2+]i in SHR. Downregulation of TRPM7, but not TRPM6, may play a role in altered Mg2+ homeostasis in VSMCs from SHR.

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