scholarly journals Effect of Body Weight Loss on Blood Pressure After 6 Years of Follow-Up in Stage 1 Hypertension

2006 ◽  
Vol 19 (11) ◽  
pp. 1103-1109 ◽  
Author(s):  
M WINNICKI ◽  
E BONSO ◽  
F DORIGATTI ◽  
D LONGO ◽  
V ZAETTA ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Body Weight ◽  
Body Weight Loss ◽  
Stage 1

scholarly journals Therapy of obesity by sibutramin: polymorphisms of TPH2 and GNB3 genes and decrease of body weight

2018 ◽  
Vol 15 (2) ◽  
pp. 40-45
Author(s):  
Marina O. Galieva ◽  
Ekaterina A. Troshina ◽  
Nataliya V. Mazurina ◽  
Anna P. Volynkina ◽  
Andrey V. Artiushin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Weight Loss ◽  
Body Weight ◽  
Genetic Factors ◽  
Research Study ◽  
Body Weight Loss ◽  
The Body ◽  
Tph2 Gene

Aims. To study of the polymorphisms of the TPN2 and GNB3 genes in obese patients and their effect on weight loss in patients on sibutramine therapy. Materials and methods. The research study included 118 patients with exogenous-constitutional obesity who received Reduxin (sibutramine + CMC) at the dose of 10 mg. Term follow-up was 3 months. A genetic study was performed to assess ТРН2 and GNB3 gene polymorphisms. The response to the therapy was evaluated after 3 months by the dynamics of body weight. Results. In the study the G703T polymorphism of the GNB3 gene showed that during 3 months of observation, carriers of the TT genotype had a greater decrease in body weight in comparison with carriers of the allele C -8 kg (-12; -5) vs. -5 kg (-8; -3), p = 0.018. In carriers of different variants of the genotype of the TPH2 gene (polymorphism C825T), there was no difference in body weight dynamics with sibutramine therapy. There was no correlation between the foresaid polymorphisms of the TPH2 and GNB3 genes with the indices of blood pressure and heart rate. Conclusions. 1. The result of sibutramin therapy may depend on genetic factors: in carriers of the TT-genotype C825T of the GNB3 gene the body weight loss was higher than among the carriers of the C allele. 2. Changes in blood pressure and heart rate did not show any statistically significant relationship with polymorphisms of the TPH2 and GNB3 genes.

scholarly journals Effect of body weight loss and normalization on blood pressure in overweight non-obese patients with stage 1 hypertension

2010 ◽  
Vol 33 (3) ◽  
pp. 236-242 ◽  
Author(s):  
Roberto Fogari ◽  
Annalisa Zoppi ◽  
Luca Corradi ◽  
Paola Preti ◽  
Amedeo Mugellini ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Body Weight ◽  
Body Weight Loss ◽  
Obese Patients ◽  
Stage 1

scholarly journals Therapy of obesity by sibutramin: polymorphisms of TPH2 and GNB3 genes and decrease of body weight

2018 ◽  
Vol 15 (2) ◽  
pp. 40-45
Author(s):  
Marina O Galieva ◽  
Ekaterina A Troshina ◽  
Nataliya V Mazurina ◽  
Anna P Volynkina ◽  
Andrey Artiushin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Weight Loss ◽  
Body Weight ◽  
Genetic Factors ◽  
Research Study ◽  
Body Weight Loss ◽  
The Body ◽  
Tph2 Gene

AIMS. To study of the polymorphisms of the TPN2 and GNB3 genes in obese patients and their effect on weight loss in patients on sibutramine therapy. MATERIALS AND METHODS. The research study included 118 patients with exogenous-constitutional obesity who received Reduxin (sibutramine + CMC) at the dose of 10 mg. Term follow-up was 3 months. A genetic study was performed to assess ТРН2 and GNB3 gene polymorphisms. The response to the therapy was evaluated after 3 months by the dynamics of body weight. RESULTS. In the study the G703T polymorphism of the GNB3 gene showed that during 3 months of observation, carriers of the TT genotype had a greater decrease in body weight in comparison with carriers of the allele C – -8 kg (-12; -5) vs. -5 kg (-8; -3), p = 0.018. In carriers of different variants of the genotype of the TPH2 gene (polymorphism C825T), there was no difference in body weight dynamics with sibutramine therapy. There was no correlation between the foresaid polymorphisms of the TPH2 and GNB3 genes with the indices of blood pressure and heart rate. CONCLUSIONS. 1. The result of sibutramin therapy may depend on genetic factors: in carriers of the TT-genotype C825T of the GNB3 gene the body weight loss was higher than among the carriers of the C allele. 2. Changes in blood pressure and heart rate did not show any statistically significant relationship with polymorphisms of the TPH2 and GNB3 genes.

Mechanism of Gastric Bypass–Induced Body Weight Loss: One-Year Follow-up After Micro–Gastric Bypass in Rats

2006 ◽  
Vol 10 (10) ◽  
pp. 1384-1391 ◽  
Author(s):  
B STENSTROM ◽  
M FURNES ◽  
K TOMMERAS ◽  
U SYVERSEN ◽  
C ZHAO ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Body Weight ◽  
Body Weight Loss ◽  
One Year

scholarly journals Two-year follow-up cohort study focused on gender-specific associations between socioeconomic status and body weight changes in overweight and obese middle-aged and older adults

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e050127
Author(s):  
Malgorzata Biskup ◽  
Pawel Macek ◽  
Stanislaw Gozdz ◽  
Malgorzata Terek-Derszniak ◽  
Halina Krol ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Weight Loss ◽  
Body Weight ◽  
Low Income ◽  
Body Weight Loss ◽  
Occupational Activity ◽  
Weight Changes ◽  
Body Weight Changes ◽  
Gender Specific

ObjectiveAs overall spread of obesity in populations is generally acknowledged to result from unhealthy lifestyles rather than individual genetic makeup, this study aimed to gain specific insights into its determinants through assessing the prevalent associations between individual socioeconomic status (SES) and weight loss in overweight and obese men and women.MethodsA prospective, 2-year follow-up study covered 3362 (38.0% men) respondents, aged 43–64 years, body mass index ≥25 kg/m2. Changes in body weight were estimated as a percentage of initial weight. Three categories of changes were defined: gained ≥3%, stable (gained <3% or lost <3%), lost ≥3%. Body weight loss was determined against three categories: lost ≥3 to <5%, lost ≥5 to <10%, lost ≥10%. Select SES variables (ie, gender, age, education, marital status, occupational activity and income) were determined in line with the Health Status Questionnaire. The associations between SES and body weight changes were analysed with the aid of logistic regression models. The results were presented as ORs with 95% CIs.ResultsOnly 18% of the respondents had complied with the medical recommendations on weight loss. Significant differences were encountered between the gender, age and occupational activity variables and the weight loss one. Multifactorial models were used to determine the following gender-specific associations between SES and weight loss. Men with moderate income had significantly higher odds for weight loss (≈75%), as compared with the higher earners, whereas women with low income, occupationally inactive, had significantly higher odds (≈30% and ≈50%, respectively), as compared with the high earners and occupationally active ones.ConclusionsLower education, male gender, lower income per household, older age and unemployment status were the established factors predisposing to obesity. While aiming to ensure effectiveness of the measures specifically aimed at preventing obesity, population groups deemed most at risk of potential weight gain must prior be identified.

scholarly journals Pre-Clinical Cushing's Syndrome with Body Weight Loss and Normal Circadian Rhythm of Blood Pressure.

1998 ◽  
Vol 37 (6) ◽  
pp. 528-533 ◽  
Author(s):  
Taku IWAMI ◽  
Tetsuya NAKAMURA ◽  
Nogiku NIWAMAE ◽  
Takahiro YAMAGISHI ◽  
Toshihiro UTSUGI ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Body Weight ◽  
Circadian Rhythm ◽  
Cushing’S Syndrome ◽  
Body Weight Loss ◽  
Cushing's Syndrome

scholarly journals Hypocaloric Dieting Unsettles the Neuroenergetic Homeostasis in Humans

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3433
Author(s):  
Ewelina K. Wardzinski ◽  
Carolin Hyzy ◽  
Kai Duysen ◽  
Uwe H. Melchert ◽  
Kamila Jauch-Chara ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Standardized Test ◽  
Body Weight Loss ◽  
Stress Axis ◽  
Energy Status ◽  
C Peptide ◽  
Low Calorie ◽  
Baseline Levels

Background: The effects of low-calorie dieting in obesity are disappointing in the long run. The brain’s energy homeostasis plays a key role in the regulation of body weight. We hypothesized that the cerebral energy status underlies an adaptation process upon body weight loss due to hypocaloric dieting in humans. Objective: We instructed 26 healthy obese participants to reduce body weight via replacement of meals by a commercial diet product for two weeks. The cerebral energy status was assessed by 31 phosphorus magnetic resonance spectroscopy (31 PMRS) before and after low-caloric dieting as well as at follow-up. A standardized test buffet was quantified after body weight loss and at follow-up. Blood glucose metabolism and neurohormonal stress axis activity were monitored. Results: Weight loss induced a decline in blood concentrations of insulin (p = 0.002), C-peptide (p = 0.005), ACTH (p = 0.006), and norepinephrine (p = 0.012). ATP/Pi (p = 0.003) and PCr/Pi ratios (p = 0.012) were increased and NADH levels reduced (p = 0.041) after hypocaloric dieting. At follow-up, weight loss persisted (p < 0.001), while insulin, C-peptide, and ACTH increased (p < 0.005 for all) corresponding to baseline levels again. Despite repealed hormonal alterations, ratios of PCr/Pi remained higher (p = 0.039) and NADH levels lower (p = 0.007) 6 weeks after ending the diet. ATP/Pi ratios returned to baseline levels again (p = 0.168). Conclusion: Low-calorie dieting reduces neurohormonal stress axis activity and increases the neuroenergetic status in obesity. This effect was of a transient nature in terms of stress hormonal measures. In contrast, PCr/Pi ratios remained increased after dieting and at follow-up while NADH levels were still reduced, which indicates a persistently unsettled neuroenergetic homeostasis upon diet-induced rapid body weight loss.

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