scholarly journals Retinoid X receptor agonist improves endothelial dysfunction in spontaneously hypertensive rats

2005 ◽  
Vol 18 (5) ◽  
pp. A242-A242
Author(s):  
B HE ◽  
J PU
Keyword(s):  
Endothelial Dysfunction ◽  
Receptor Agonist ◽  
Spontaneously Hypertensive Rats ◽  
Retinoid X Receptor ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Aging Additively Influences Insulin- and Insulin-Like Growth Factor-1-Mediated Endothelial Dysfunction and Antioxidant Deficiency in Spontaneously Hypertensive Rats

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 676
Author(s):  
Kunanya Masodsai ◽  
Yi-Yuan Lin ◽  
Sih-Yin Lin ◽  
Chia-Ting Su ◽  
Shin-Da Lee ◽  
...  
Keyword(s):  
Growth Factor ◽  
Endothelial Dysfunction ◽  
Spontaneously Hypertensive Rats ◽  
No Production ◽  
Organ Bath ◽  
Insulin Like Growth Factor ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Nos Inhibitors ◽  
Wistar Kyoto

This study aimed to investigate the aging-related endothelial dysfunction mediated by insulin and insulin-like growth factor-1 (IGF-1) and antioxidant deficiency in hypertension. Male spontaneously hypertensive rats (SHRs) and age-matched normotensive Wistar–Kyoto rats (WKYs) were randomly divided into 24-week-old (younger) and 48-week-old (older) groups, respectively. The endothelial function was evaluated by the insulin- and IGF-1-mediated vasorelaxation of aortic rings via the organ bath system. Serum levels of nitric oxide (NO), malondialdehyde (MDA), catalase, and total antioxidant capacity (TAC) were examined. The insulin- and IGF-1-mediated vasorelaxation was significantly impaired in both 24- and 48-week-old SHRs compared with age-matched WKYs and was significantly worse in the 48-week-old SHR than the 24-week-old SHR. After pretreatments of phosphoinositide 3-kinase (PI3K) or NO synthase (NOS) inhibitors, the insulin- and IGF-1-mediated vasorelaxation became similar among four groups. The serum level of MDA was significantly increased, while the NO, catalase, and TAC were significantly reduced in the 48-week-old SHR compared with the 24-week-old SHR. This study demonstrated that the process of aging additively affected insulin- and IGF-1-mediated endothelial dysfunction in SHRs, which could be partly attributed to the reduced NO production and antioxidant deficiency.

Is the balance between nitric oxide and superoxide altered in spontaneously hypertensive rats with endothelial dysfunction?

2001 ◽  
Vol 16 (suppl_1) ◽  
pp. 2-5 ◽  
Author(s):  
Guillermo Zalba ◽  
Francisco J. Beaumont ◽  
Gorka San José ◽  
Ana Fortuño ◽  
María A. Fortuño ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals TORCETRAPIB INDUCES ENDOTHELIAL DYSFUNCTION IN SPONTANEOUSLY HYPERTENSIVE RATS

2010 ◽  
Vol 55 (10) ◽  
pp. A166.E1558
Author(s):  
Branko Simic ◽  
Matthias Hermann ◽  
Sidney Shaw ◽  
Thomas F. Luescher ◽  
Frank Ruschitzka
Keyword(s):  
Endothelial Dysfunction ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
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