scholarly journals Does the combination of angiotensin II receptor blocker with diuretic decrease blood pressure more effectively than the increase of its dose?

2005 ◽  
Vol 18 (5) ◽  
pp. A65-A65
Author(s):  
I KANTOLA ◽  
T NIIRANEN ◽  
M RUUSKA ◽  
J JOHANSSON
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Receptor Blocker ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Decrease Blood Pressure

scholarly journals Management of Home Blood Pressure by Amlodipine Combined With Angiotensin II Receptor Blocker in Type 2 Diabetes

2012 ◽  
Vol 76 (9) ◽  
pp. 2159-2166 ◽  
Author(s):  
Katsumi Miyauchi ◽  
Tsutomu Yamazaki ◽  
Hirotaka Watada ◽  
Yasushi Tanaka ◽  
Ryuzo Kawamori ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Angiotensin Ii ◽  
Home Blood Pressure ◽  
Receptor Blocker ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor

scholarly journals Summertime dosage-dependent hypersensitivity to an angiotensin II receptor blocker

2014 ◽  
Author(s):  
Donald R Forsdyke
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Antihypertensive Medication ◽  
Large Scale ◽  
Receptor Blocker ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
J Curve ◽  
Differential Signaling

Summertime dips in blood pressure (BP), both in normotensive and hypertensive subjects, are well known. However, the dips are small and are not related to particular forms or doses of antihypertensive medication. Nevertheless it is the practice in some quarters to decrease antihypertensive medication in summer, and/or increase in winter. Large scale studies being inconclusive, there are calls for long-term examination of the relationship between environmental temperature and blood pressure in single individuals under medication. While analyzing data from a subject whose BP had been controlled for a decade with the angiotensin-II receptor blocker losartan, an extreme, dosage-dependent, summertime dip came to light. Downward dosage adjustment appeared essential and may have prevent hypotension-related pathology. The benefits of aggressive medication (the “J curve” phenomenon) being debated, the possibility of seasonal hypersensitivity, explicable in terms of differential signaling by countervailing receptors, should be taken into account when considering dosage adjustments in hypertensive subjects.

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