scholarly journals Serum uric acid as a marker of target organ damage in primary hypertension

2005 ◽  
Vol 18 (5) ◽  
pp. A1-A1
Author(s):  
F VIAZZI ◽  
G LEONCINI ◽  
E RATTO ◽  
V VACCARO ◽  
A PARODI ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Primary Hypertension

A predictive marker for target organ damage in primary hypertension: serum uric acid levels

2021 ◽  
pp. 31-36
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Robust Regression ◽  
Target Organ Damage ◽  
Predictive Marker ◽  
Intima Media Thickness ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Primary Hypertension

Background: This study aims to investigate the relationship between serum uric acid levels, the left ventricular mass index (LVMI), and carotid intima-media thickness (CIMT) in primary hypertension patients. Material and Method: A total of 139 primary hypertension patients, including 45 (32.4%) men and 94 (67.6%) women were involved in the study. The laboratory and clinical demographic findings, as well as the LVMI and CIMT levels of the patients, were collected from patient files. Results: 37% of the study population were found to have hyperuricemia. LVMI (99.75}13.4 vs 86.17±17.6; p=0.010) and CIMT (0.88±0.26 vs 0.75±0.17; p=0.023) levels were found to be higher in the hyperuricemia versus the non-hyperuricemia group. According to the correlation analysis, there was a positive correlation between uric acid and LVMI (r=0.282, p=0.032) and CIMT (r=0.285, p=0.002) levels. Robust regression analysis showed that uric acid was an independent risk factor for both the LVMI (β±SE: 1.615±1.03, p<0.05) and CIMT (β±SE: 0.251±0.09, p<0.05). Conclusion: We found serum uric acid levels to be closely related to the target organ damage associated with primary hypertension, and even related with target organ damage independent from blood pressure.

scholarly journals Serum Uric Acid and Target Organ Damage in Primary Hypertension

Hypertension ◽  
2005 ◽  
Vol 45 (5) ◽  
pp. 991-996 ◽  
Author(s):  
Francesca Viazzi ◽  
Denise Parodi ◽  
Giovanna Leoncini ◽  
Angelica Parodi ◽  
Valeria Falqui ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Primary Hypertension

scholarly journals The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ damage

2005 ◽  
Vol 19 (3) ◽  
pp. 211-217 ◽  
Author(s):  
C Tsioufis ◽  
D Chatzis ◽  
E Vezali ◽  
K Dimitriadis ◽  
D Antoniadis ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ

RELATIONSHIP OF SERUM URIC ACID LEVELS WITH INDICES OF TARGET ORGAN DAMAGE IN ESSENTIAL HYPERTENSIVE PATIENTS

2004 ◽  
Vol 22 (Suppl. 2) ◽  
pp. S236-S237
Author(s):  
E. Vezali ◽  
C. Tsioufis ◽  
E. Taxiarchou ◽  
K. Dimitriadis ◽  
L. Naoumidou ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Hypertensive Patients ◽  
Relationship Of

scholarly journals SERUM URIC ACID AND TARGET ORGAN DAMAGE IN ESSENTIAL HYPERTENSION AT MEDICINE DEPARTMENT OF GMC, BETTIAH, BIHAR

2020 ◽  
pp. 1-3
Author(s):  
Mahendra Kumar ◽  
Dharmendra Prasad ◽  
Parshuram Yugal ◽  
Debarshi Jana
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Left Ventricular Hypertrophy ◽  
Serum Uric Acid ◽  
Ventricular Hypertrophy ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Hypertensive Patients

Background Hypertension is a major risk factor for cardiovascular mortality, as it acts through its effects on target organs, such as the heart and kidneys. Hyperuricemia increases cardiovascular risk in patients with hypertension. Objective To assess the relationship between serum uric acid and target organ damage (left ventricular hypertrophy and microalbuminuria) in untreated patients with essential hypertension. Patients and methods: A cross-sectional study was carried out in 130 (85 females, 45 males) newly diagnosed, untreated patients with essential hypertension. Sixty-five healthy age- and sex-matched non-hypertensive individuals served as controls for comparison. Left ventricular hypertrophy was evaluated by cardiac ultrasound scan, and microalbuminuria was assessed in an early morning midstream urine sample by immunoturbidimetry. Blood samples were collected for assessing uric acid levels. Results Mean serum uric acid was significantly higher among the patients with hypertension (379.7±109.2 μmol/L) than in the controls (296.9±89.8 μmol/L; P<0.001), and the prevalence of hyperuricemia was 46.9% among the hypertensive patients and 16.9% among the controls (P<0.001). Among the hypertensive patients, microalbuminuria was present in 54.1% of those with hyperuricemia and in 24.6% of those with normal uric acid levels (P=0.001). Similarly, left ventricular hypertrophy was more common in the hypertensive patients with hyperuricemia (70.5% versus 42.0%, respectively; P=0.001). There was a significant linear relationship between mean uric acid levels and the number of target organ damage (none versus one versus two: P=0.012). Conclusion These results indicate that serum uric acid is associated with target organ damage in patients with hypertension, even at the time of diagnosis; thus, it is a reliable marker of cardiovascular damage in our patient population.

P56 ASSOCIATION BETWEEN URIC ACID AND CARDIAC, VASCULAR AND RENAL TARGET ORGAN DAMAGE IN HYPERTENSIVES SUBJECTS

2017 ◽  
Vol 20 (C) ◽  
pp. 69
Author(s):  
Alessandro Maloberti ◽  
Marisa Varrenti ◽  
Nicola Triglione ◽  
Lucia Occhi ◽  
Francesco Panzeri ◽  
...  
Keyword(s):  
Uric Acid ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ
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