scholarly journals At1 receptor blockers improve endothelial function (EF) and fibrinolytic activity (FA) in hypertensive patients with initial target organ damage

2004 ◽  
Vol 17 (5) ◽  
pp. S64
Author(s):  
M CAMPANELLA
Keyword(s):  
Endothelial Function ◽  
Fibrinolytic Activity ◽  
Target Organ Damage ◽  
Organ Damage ◽  
At1 Receptor ◽  
Target Organ ◽  
Hypertensive Patients ◽  
Receptor Blockers ◽  
At1 Receptor Blockers ◽  
Initial Target

scholarly journals Impaired endothelial function in hypertensive patients with target organ damage

2009 ◽  
Vol 23 (11) ◽  
pp. 751-757 ◽  
Author(s):  
J-Z Xu ◽  
Y Zhang ◽  
S-N Wu ◽  
W-Q Niu ◽  
D-L Zhu ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Hypertensive Patients

scholarly journals Effects of irbesartan on phenotypic alterations in monocytes and the inflammatory status of hypertensive patients with left ventricular hypertrophy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jingsi Zhang ◽  
Lina Yang ◽  
Yanchun Ding
Keyword(s):  
Ventricular Hypertrophy ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Hypertensive Patients ◽  
Inflammatory Status ◽  
Tnf Α

Abstract Background Circulating monocytes and tissue macrophages play complex roles in the pathogenesis of hypertension and the resulting target organ damage. In this study, we observed alterations in the monocyte phenotype and inflammatory state of hypertensive patients with left ventricular hypertrophy (LVH) and studied the effects of irbesartan in these patients. This study might reveal a novel mechanism by which irbesartan alleviates LVH, and it could provide new targets for the prevention and treatment of hypertensive target organ damage. Methods CD163 and CD206 expression on monocytes and IL-10 and TNF-α levels in the serum of hypertensive patients with or without LVH and of healthy volunteers were detected. Furthermore, we treated monocytes from the LVH group with different concentrations of irbesartan, and then, CD163, CD206, IL-10 and TNF-α expression was detected. Results We found, for the first time, that the expression of CD163, CD206 and IL-10 in the LVH group was lower than that in the non-LVH group and healthy control group, but the TNF-α level in the LVH group was significantly higher. Irbesartan upregulated the expression of CD163 and CD206 in hypertensive patients with LVH in a concentration-dependent manner. Irbesartan also increased the expression of IL-10 and inhibited the expression of TNF-α in monocyte culture supernatants in a concentration-dependent manner. Conclusions Our data suggest that inflammation was activated in hypertensive patients with LVH and that the monocyte phenotype was mainly proinflammatory. The expression of proinflammatory factors increased while the expression of anti-inflammatory factors decreased. Irbesartan could alter the monocyte phenotype and inflammatory status in hypertensive patients with LVH. This previously unknown mechanism may explain how irbesartan alleviates LVH. Trail registration The study protocols were approved by the Ethical Committee of the Second Affiliated Hospital of Dalian Medical University. Each patient signed the informed consent form.

scholarly journals Target organ damage in hypertensive patients: correlation between retinal arteriovenular ratio and left ventricular geometric patterns

2013 ◽  
Vol 28 (4) ◽  
pp. 274-278 ◽  
Author(s):  
R Meazza ◽  
C Scardino ◽  
L Grosso Di Palma ◽  
G L Perrucci ◽  
E Gallazzi ◽  
...  
Keyword(s):  
Target Organ Damage ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Hypertensive Patients ◽  
Geometric Patterns

Prevalence of target organ damage in treated hypertensive patients

2000 ◽  
Vol 18 (6) ◽  
pp. 803-809 ◽  
Author(s):  
Cesare Cuspidi ◽  
Laura Lonati ◽  
Lorena Sampieri ◽  
Iassen Michev ◽  
Giuseppe Macca ◽  
...  
Keyword(s):  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Hypertensive Patients
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