scholarly journals Central I1- imidazoline receptors and blood pressure: a crosstalk with ?2-adrenergic receptors

2004 ◽  
Vol 17 (5) ◽  
pp. S13
Author(s):  
P BOUSQUET
Keyword(s):  
Blood Pressure ◽  
Adrenergic Receptors ◽  
Imidazoline Receptors

The imidazoline receptor in control of blood pressure by clonidine and allied drugs

1997 ◽  
Vol 273 (5) ◽  
pp. R1569-R1571 ◽  
Author(s):  
Donald J. Reis ◽  
John E. Piletz
Keyword(s):  
Blood Pressure ◽  
Arterial Pressure ◽  
Adrenergic Receptors ◽  
Antihypertensive Agents ◽  
Ventrolateral Medulla ◽  
Tonic Activity ◽  
Imidazoline Receptors ◽  
Imidazoline Receptor ◽  
Central Actions ◽  
Competing Hypotheses

Clonidine, moxonidine, and rilmenidine are centrally acting antihypertensive agents that lower arterial pressure by inhibiting the tonic activity of sympathoexcitatory neurons in the rostral ventrolateral medulla. Competing hypotheses have been put forward by different investigators to explain the sympathoinhibition evoked by “imidazoline drugs”: either via central actions at α2-adrenergic receptors or novel I1-imidazoline receptors. These different perspectives are presented in the accompanying reviews.

History of vascular reactivity models and their involvement in hypertension pathogenesis

VASA ◽  
2017 ◽  
Vol 46 (6) ◽  
pp. 431-439 ◽  
Author(s):  
Ana Gabriela Conceição-Vertamatti ◽  
Filipy Borghi ◽  
Fernando Canova ◽  
Dora Maria Grassi-Kassisse
Keyword(s):  
Blood Pressure ◽  
Adrenergic Receptors ◽  
Vascular Reactivity ◽  
Multifactorial Disease ◽  
Pharmacological Treatments ◽  
Beta Adrenergic Receptors ◽  
Vascular Area ◽  
History Of ◽  
Record Blood Pressure ◽  
Advance Knowledge

Abstract. Hypertension is a silent and multifactorial disease. Over two centuries ago, the first device to record blood pressure was developed, making it possible to determine normotension and to establish criteria for hypertension. Since then, several studies have contributed to advance knowledge in this area, promoting significant advances in pharmacological treatments and, as a result, increasing survival of hypertensive people. The main models developed for the study of hypertension and the main findings in the vascular area are included in this review. We considered aspects related to vascular reactivity, changes in the population, and action of beta adrenergic receptors in the pathogenesis of hypertension.

Differential cardiorespiratory control elicited by activation of ventral medullary sites in mice

2000 ◽  
Vol 89 (2) ◽  
pp. 437-444 ◽  
Author(s):  
F. P. Tolentino-Silva ◽  
M. A. Haxhiu ◽  
P. Ernsberger ◽  
S. Waldbaum ◽  
I. A. Dreshaj
Keyword(s):  
Blood Pressure ◽  
Adrenergic Receptors ◽  
Excitatory Amino Acid ◽  
Signal Transduction Pathway ◽  
Ventrolateral Medulla ◽  
Respiratory Drive ◽  
Breathing Frequency ◽  
Cardiorespiratory Control ◽  
Blood Pressure Responses ◽  
Stimulation Of

We studied the respiratory and blood pressure responses to chemical stimulation of two regions of the ventral brainstem in mice: the rostral and caudal ventrolateral medulla (RVLM and CVLM, respectively). Stimulation of the RVLM by microinjections of the excitatory amino acid l-glutamate induced increases in diaphragm activity and breathing frequency, elevation of blood pressure (BP), and a slight increase in heart rate (HR). However, activation of the CVLM induced a decrease in breathing frequency, mainly due to prolongation of expiratory time (Te), and hypotension associated with a slight slowing of HR. Because adrenergic mechanisms are known to participate in the control of respiratory timing, we examined the role of α2-adrenergic receptors in the RVLM region in mediating these inhibitory effects. The findings demonstrated that blockade of the α2-adrenergic receptors within the RVLM by prior microinjection of SKF-86466 (an α2-adrenergic receptor blocker) significantly reduced changes in Te induced by CVLM stimulation but had little effect on BP responses. These results indicate that, in mice, activation of the RVLM increases respiratory drive associated with an elevation of BP, but stimulation of CVLM induces prolongation of Te via an α2-adrenergic signal transduction pathway.

Increase of ovarian progesterone secretion by β2-adrenergic stimulation in oestrous rats

1982 ◽  
Vol 101 (2) ◽  
pp. 268-272 ◽  
Author(s):  
Béla Zsolnai ◽  
Bertalan Varga ◽  
Edit Horváth
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Adrenergic Receptors ◽  
Hormone Secretion ◽  
Regulatory Role ◽  
Blood Levels ◽  
Ovarian Hormone ◽  
Adrenergic Stimulation ◽  
Venous Outflow ◽  
Progesterone Secretion

Abstract. Oestrous rats were anaesthetized with pentobarbital and one of the femoral arteries, femoral veins and utero-ovarian veins were cannulated. Five min blood fractions were collected from the ovary for 50 min. Following two control fractions fenoterol, noradrenaline, isoproterenol (0.5 μg/min) or 0.9% NaCl (0.02 ml/min) were infused iv for 40 min. In a group of oestrous animals fenoterol was given locally to the ovarian bursa. Blood pressure and the ovarian venous outflow were continuously recorded and blood levels of progesterone (P) and oestradiol-17β (E2) were determined by RIA. Fenoterol administered iv increased P secretion without altering ovarian blood flow, whereas noradrenaline and isoproterenol had no effect on P secretion. Fenoterol administered locally stimulated both P and E2 secretion, and this was prevented by iv infusion of propranolol. It is suggested that ovarian β2-adrenergic receptors have a regulatory role in ovarian hormone secretion.

scholarly journals The imidazoline receptors and the central regulation of the arterial blood pressure: a minireview

1993 ◽  
Vol 88 (2) ◽  
pp. 317-325 ◽  
Author(s):  
Eduardo Tibiriça ◽  
Giampiero Bricca ◽  
Monique Dontenwill ◽  
Josiane Feldman ◽  
Hugues Greney ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Central Regulation ◽  
Imidazoline Receptors ◽  
Arterial Blood

CENTRALLY ACTING DRUGS WITH NO EFFCET AT ALPHA2-ADRENERGIC RECEPTORS CAN REDUCE BLOOD PRESSURE ARGUMENTS FOR RESEARCH AND DEVELOPMENT

2004 ◽  
Vol 22 (Suppl. 1) ◽  
pp. S121
Author(s):  
P. Bousquet ◽  
V. Bruban ◽  
H. Greney ◽  
S. Schann ◽  
J. D. Ehrhardt ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Research And Development ◽  
Adrenergic Receptors ◽  
Reduce Blood Pressure

scholarly journals Effects of β-adrenergic receptor agonists on drinking and arterial blood pressure in young and old rats

2011 ◽  
Vol 300 (4) ◽  
pp. R1001-R1008 ◽  
Author(s):  
Robert L. Thunhorst ◽  
Connie L. Grobe ◽  
Terry G. Beltz ◽  
Alan Kim Johnson
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Adrenergic Receptors ◽  
Adrenergic Receptor ◽  
Aged Rats ◽  
Middle Aged ◽  
Young Rats ◽  
Arterial Blood ◽  
Age Related ◽  
Old Rats

These experiments examined water-drinking and arterial blood pressure responses to β-adrenergic receptor activation in young (4 mo), “middle-aged” adult (12 mo), and old (29 mo) male rats of the Brown-Norway strain. We used isoproterenol to simultaneously activate β1- and β2-adrenergic receptors, salbutamol to selectively activate β2-adrenergic receptors, and the combination of isoproterenol and the β2-adrenergic receptor antagonist ICI 118,551 to stimulate only β1-adrenergic receptors. Animals received one of the drug treatments, and water drinking was measured for 90 min. About 1 wk later, animals received the same drug treatment for measurement of arterial blood pressure responses for 90 min. In some rats, levels of renin and aldosterone secretion in response to isoproterenol or salbutamol were measured in additional tests. Old and middle-aged rats drank significantly less after isoproterenol than did young rats and also had greater reductions in arterial blood pressure. Old and middle-aged rats drank significantly less after salbutamol than did young rats, although reductions in arterial blood pressure were equivalent across the ages. The β2-adrenergic antagonist ICI 118,551 abolished drinking after isoproterenol and prevented most of the observed hypotension. Renin secretion after isoproterenol and salbutamol was greater in young rats than in middle-aged rats, and wholly absent in old rats. Aldosterone secretion was reduced in old rats compared with young and middle-aged rats after treatment with isoproterenol, but not after treatment with salbutamol. In conclusion, there are age-related differences in β-adrenergic receptor-mediated drinking that can be explained only in part by age-related differences in renin secretion after β-adrenergic receptor stimulation.

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