scholarly journals Effects of the angiotensin II receptor blockers telmisartan versus valsartan on the circadian variation of blood pressure impact on the early morning period

2004 ◽  
Vol 17 (4) ◽  
pp. 347-353 ◽  
Author(s):  
W White
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Circadian Variation ◽  
Early Morning ◽  
Angiotensin Ii Receptor Blockers ◽  
Angiotensin Ii Receptor ◽  
Pressure Impact ◽  
Receptor Blockers

scholarly journals A short term evaluation of effect on serum urea, creatinine and potassium levels with use of angiotensin II receptor blockers (olmesartan or telmisartan) in stage 1 hypertensive patients

2019 ◽  
Vol 8 (10) ◽  
pp. 2328
Author(s):  
Varun Gupta ◽  
Pooja Singh
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Randomized Study ◽  
Angiotensin Ii Receptor Blockers ◽  
North India ◽  
Serum Urea ◽  
Angiotensin Ii Receptor ◽  
Hypertensive Patients ◽  
Receptor Blockers ◽  
Stage 1

Background: Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (ARBs) are being used as first line agents for the treatment of hypertension in haemodialysis patients as well as in the general population. Serious hyperkalemia is common in patients with end-stage renal disease, and is observed in about 10% of haemodialysis patients. Although many research have been done so far to compare the antihypertensive efficacy of ARBs, but such studies to evaluate the effect on serum urea, creatinine and potassium levels are not so common in North India region.Methods: In this open label, prospective, randomized study, we evaluated the effect on serum urea, creatinine and potassium levels with use of ARB’s (olmesartan or telmisartan) in stage 1 hypertensive patients (JNCVII). 60 patients were randomized in to two groups. The odd numbers will be allotted olmesartan 20 mg (group A) and even numbers to telmisartan 40 mg (group B). Impacts on serum urea, creatinine and potassium levels were evaluated after 12 weeks.Results: Our results indicates that there was no statistically significant alterations in mean serum creatinine, blood urea and in mean serum potassium levels compared to baseline within the two groups as well as when mean of both groups were compared, olmesartan showed a better reduction in blood pressure as compared to telmisartan.Conclusions: Olmesartan showed a better reduction in blood pressure with similar effects in biochemical parameters as telmisartan.

scholarly journals Impact of angiotensin II receptor blockers on changes in office, central blood pressure and circadian blood pressure in relation to morning or evening reception

2019 ◽  
Vol 26 (5) ◽  
pp. 23-32
Author(s):  
O. L. Rekovets ◽  
Yu. M. Sirenko ◽  
O. O. Torbas ◽  
C. M. Kushnir ◽  
G. F. Prymak
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Moderate Hypertension ◽  
Office Blood Pressure ◽  
Angiotensin Ii Receptor Blockers ◽  
Central Blood Pressure ◽  
Angiotensin Ii Receptor ◽  
Daily Monitoring ◽  
Circadian Blood Pressure ◽  
Receptor Blockers

The aim – to evaluate the effect of angiotensin II receptor blockers – olmesartan, azilsartan and telmisartan – taken in the morning or evening hours, on office, central blood pressure under daily monitoring and to assess circadian blood pressure. Materials and methods. The study included 126 patients with mild to moderate hypertension that were selected to compare the effect of drug pharmacotherapy with angiotensin II receptor blockers – olmesartan, azilsartan and telmisartan on morning and evening hours. Patients were distributed into 6 groups: 1st group 20 patients taking olmesartan 20–40 mg in the morning, 2nd group – 20 patients taking olmesartan 20–40 mg in the evening hours, 3rd – 21 patients taking azilsartan 40–80 mg in the morning, 4th – 20 patients taking azilsartan 40–80 mg in the evening, 5th – 22 patients taking telmisartan 40–80 mg in the morning, 6th – patients taking telmisartan 40–80 mg in the evening. Patients underwent primary and re-examination followed 3 months of the therapy. Results and discussion. Lowering of office SBP/DBP in the olmesartan intake group in the evening hours was – 20.95/13.50 mm Hg (p<0.05), and when taken in the morning hours – 19.40/8.95 mm Hg (p<0.05). In the group of azіlsartan therapy, the lowering of office SBP/DBP in the evening hours was 21.10/11.50 mm Hg (p<0.05), and taken in the morning hours – 20.05/12.23 mm Hg (p<0.05). In the telmisartan intake group, the lowering of office SBP/DBP during in the evening was 19.54/9.00 mm Hg (p<0.05), and taken in the morning hours – 21.22/12.29 mm Hg (p<0.05). Lowering of central blood pressure was equally effective and did not depend on the time of taking the drugs. Lowering of central SBP with olmesartan intake was 3 months after administration in the evening hours – 18.34 mm Hg, in the morning – 15.22 mm Hg, while taking azilsartan – respectively 15.59 and 19.24 mm Hg, while taking telmisartan – respectively 12.00 and 18.00 mm Hg. Reaching of the target office blood pressure with olmesartan therapy was observed in 77.50 % of patients, with azilsartan in 78.05 % of patients, and with telmisartan in 78.57 % of patients. The intake of olmesartan, azilsartan and telmisartan did not statistically significantly affect the circadian blood pressure. Conclusions. The use of olmesartan, azilsartan and telmisartan equally effectively lowered office and central blood pressure when taken both in the morning and evening hours, and did not have a statistically significant effect on changes in blood circadian pressure.

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