scholarly journals Pravastatin has an additional depressor effect in patients undergoing long-term treatment with antihypertensive drugs

2004 ◽  
Vol 17 (6) ◽  
pp. 502-506 ◽  
Author(s):  
T IKEDA
Keyword(s):  
Antihypertensive Drugs ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Depressor Effect

Long-term treatment of idiopathic hyperaldosteronim using trilostane

1986 ◽  
Vol 113 (1) ◽  
pp. 104-110 ◽  
Author(s):  
Kaoru Nomura ◽  
Hiroshi Demura ◽  
Nobuo Horiba ◽  
Kazuo Shizume
Keyword(s):  
Antihypertensive Drugs ◽  
Competitive Inhibitor ◽  
Inhibitory Effect ◽  
Term Treatment ◽  
Continuous Treatment ◽  
Steroid Biosynthesis ◽  
Long Term Treatment ◽  
Idiopathic Hyperaldosteronism ◽  
Pre Treatment

Abstract. Three patients with idiopathic hyperaldosteronism were continuously treated with trilostane, a competitive inhibitor of adrenal 3β-hydroxysteroid dehydrogenase (3β-HSDH) (3 to 4⅔ years). Trilostane, in conjunction with antihypertensive drugs, effectively decreased plasma aldosterone levels and improved hyperaldosteronism symptoms without undesirable side effects. Trilostane continued to be effective even when treatment was continuous. Rapid ACTH testing (iv bolus of 0.25 mg α1–24 ACTH) was done on the day without trilostane after long-term treatment, and plasma levels of aldosterone and cortisol were compared to those obtained during a pre-treatment period. Results suggest that the inhibitory effect of trilostane on steroid biosynthesis rapidly disappears following discontinuance of trilostane administration even after long-term treatment, and that continuous treatment causes no significant or irreversible change in steroid biosynthesis. These results suggest that trilostane is a safe, feasible therapeutic agent for long-term treatment of idiopathic hyperaldosteronism.

scholarly journals The Effect of The Number of Drugs Received On The Level of Adherence to Drug Consumption (Morisky, Green, Levine Adherence Scale Questionnaire) of Hypertensive Patients

2020 ◽  
Vol 9 (2) ◽  
pp. 840-847
Author(s):  
Iin Ernawati ◽  
Selly Septi Fandinata ◽  
Silfiana Nisa Permatasari
Keyword(s):  
Community Health Centers ◽  
Antihypertensive Drugs ◽  
Term Treatment ◽  
Drug Consumption ◽  
Health Centers ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Long Term Treatment ◽  
Adherence Scale

Hypertension is a chronic disease that requires long-term treatment, where it is very prone to non-adherence in taking antihypertensive drugs. This study aims to determine the effect of the number of drugs received by patients on the level of adherence to the consumption of antihypertensive drugs. This research is a cross-sectional observational study that was conducted in 4 community health centers in Surabaya City. The measurement of adherence in this study used the Indonesian version of the MGLS questionnaire. The number of subjects in this study was 143 which fit the inclusion criteria. The majority of the adherence levels of the study subjects were moderate (MGLS questionnaire). Based on statistical analysis, it is known that there is a significant effect (P = 0.035) of the number of drugs received by patients on the level of drug consumption adherence e as measured using the Indonesian version of the MGLS questionnaire.

Interaction of Dopamine, Methyldopa and Reserpine in the Sympatho-Adrenal System in Essential Hypertension

1976 ◽  
Vol 51 (s3) ◽  
pp. 461s-463s
Author(s):  
K. Abe ◽  
H. Aoyagi ◽  
M. Yasujima ◽  
S. Miyazaki ◽  
T. Kusaka ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Peripheral Nerve ◽  
Pressor Response ◽  
Normal Subjects ◽  
Term Treatment ◽  
Adrenal System ◽  
Long Term Treatment ◽  
Depressor Effect

1. The interactions of dopamine, reserpine and methyldopa on blood pressure of normal subjects and of those with essential hypertension were examined. 2. When biosynthesis of noradrenaline from dopamine was blocked by reserpine, dopamine induced a prominent depressor effect in essential hypertension. 3. The long-term treatment with methyldopa induced a marked potentiation of the pressor action of domapine in hypertension, although no significant pressor response was found in normal subjects. 4. It is suggested that methylnoradrenaline may accumulate in peripheral nerve endings of patients with essential hypertension in comparison with normal subjects, and this accumulated methylnoradrenaline potentiates the pressor response to dopamine in essential hypertension.

Effects of long-term treatment with antihypertensive drugs on myocardium in SHR

1992 ◽  
Vol 24 ◽  
pp. 62
Author(s):  
Nobuakira Takeda ◽  
Tohru Arino ◽  
Akira Tanamura ◽  
Takaaki Iwai ◽  
Izuru Nakamura ◽  
...  
Keyword(s):  
Antihypertensive Drugs ◽  
Term Treatment ◽  
Long Term Treatment
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