Impact of Percutaneous Coronary Intervention on the Levels of Interleukin-6 and C-Reactive Protein in the Coronary Circulation of Subjects With Coronary Artery Disease

2006 ◽  
Vol 98 (7) ◽  
pp. 915-917 ◽  
Author(s):  
Mahmoud M. Ramadan ◽  
Makoto Kodama ◽  
Wataru Mitsuma ◽  
Masahiro Ito ◽  
Takeshi Kashimura ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Percutaneous Coronary Intervention ◽  
Coronary Artery ◽  
Interleukin 6 ◽  
Coronary Circulation ◽  
Coronary Intervention ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Percutaneous Coronary ◽  
Artery Disease

Assessment of Relationship Between C-Reactive Protein to Albumin Ratio and Coronary Artery Disease Severity in Patients With Acute Coronary Syndrome

Angiology ◽  
2017 ◽  
Vol 70 (4) ◽  
pp. 361-368 ◽  
Author(s):  
Metin Çağdaş ◽  
Ibrahim Rencüzoğullari ◽  
Süleyman Karakoyun ◽  
Yavuz Karabağ ◽  
Mahmut Yesin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Percutaneous Coronary Intervention ◽  
Coronary Artery ◽  
Coronary Intervention ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Percutaneous Coronary ◽  
Study Population ◽  
Artery Disease

The association of coronary artery disease (CAD) severity with increased C-reactive protein (CRP) and decreased albumin levels has been reported. However, to our knowledge, no study has investigated the usefulness of the CRP to albumin ratio (CAR) in predicting intermediate–high SYNergy between Percutaneous Coronary Intervention with TAXus and cardiac surgery (SYNTAX) score (SS) and high SS II. Consecutive patients (n = 344) treated with percutaneous coronary intervention comprised the study population. The study population was divided into 2 groups according to SS >22 and mean SS II values, respectively. Patients with intermediate–high SS and high SS II had higher CAR than patients with low SS and SS II. History of diabetes mellitus, decreased albumin, lower left ventricular ejection fraction, and elevated CAR (odds ratio [OR]: 1.020; 95% confidence interval [CI], 1.009-1.031; P < .001) were independent predictors of high SS. The presence of hypertension, decreased hemoglobin and albumin levels, and increased CAR (OR: 1.014; 95% CI, 1.004-1.023; P < .001) were independent predictors of SS II. In receiver operating characteristic curve comparison, CAR was superior to CRP and albumin in prediction of intermediate–high SS, but only CRP in prediction of high SS II. The CAR calculated from the admission blood samples could be a useful parameter for predicting CAD severity using SS and SS II.

scholarly journals Endothelial Dysfunction and Coronary Vasoreactivity – a review of the history, physiology, diagnostic techniques and clinical relevance

2020 ◽  
Vol 16 ◽  
Author(s):  
Tharusha Gunawardena ◽  
Ioannis Merinopoulos ◽  
Upul Wickramarachchi ◽  
Vassilios Vassiliou ◽  
Simon Eccleshall
Keyword(s):  
Coronary Artery Disease ◽  
Percutaneous Coronary Intervention ◽  
Coronary Artery ◽  
Coronary Circulation ◽  
Coronary Intervention ◽  
Diagnostic Techniques ◽  
Percutaneous Coronary ◽  
Artery Disease

: The fervency for advancement and evolution in percutaneous coronary intervention has revolutionised the treatment of coronary artery disease. Historically, the focus of the interventional cardiologist was directed at the restoration of luminal patency of the major epicardial coronary arteries, yet whilst this approach is evolving with a much greater utilisation of physiological assessment, it often neglects consideration of the role of the coronary microcirculation which has been shown to clearly influence prognosis. In this review, we consider exploring the narrative of the coronary circulation as more than just a simple conduit for blood but an organ with functional significance. We discuss the organisation and physiology of the coronary circulation as well as the current methods and techniques used to examine it. We then review the studies exploring coronary artery endothelial function, appreciating that coronary artery disease occurs on a spectrum of disorder and that percutaneous coronary intervention has a latent effect on the coronary circulation with long-term consequences. We conclude that greater recognition of the coronary artery endothelium and mechanisms of the coronary circulation should guide revascularisation strategies further.

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