scholarly journals The Origin of Chronic Diseases Can Be in Capillary Pathology: An Evidence From Clinical Trials on Thermobalancing Treatment of Prostate Reveals

2016 ◽  
Vol 10 (2) ◽  
pp. 197-202 ◽  
Author(s):  
Simon Allen
Keyword(s):  
Clinical Trials ◽  
Chronic Diseases

Behavioral Clinical Trials for Chronic Diseases

2021 ◽  
Author(s):  
Lynda H. Powell ◽  
Kenneth E. Freedland ◽  
Peter G. Kaufmann
Keyword(s):  
Clinical Trials ◽  
Chronic Diseases

On the Evaluation of Treatments for Narcotics Addiction

1979 ◽  
Vol 9 (2) ◽  
pp. 205-211 ◽  
Author(s):  
Vincent P. Dole ◽  
Burton Singer
Keyword(s):  
Clinical Trials ◽  
Randomized Trial ◽  
Observational Data ◽  
Chronic Diseases ◽  
Drug Addiction ◽  
Randomized Trials ◽  
Randomized Clinical Trials ◽  
The Other ◽  
Domain Of Applicability

This study is concerned with the domain of applicability of randomized clinical trials. For evaluation of well-defined treatments of acute diseases over limited periods of time, the randomized trial technique is unquestionably the best. However, in the field of chronic diseases (as illustrated by drug addiction) the physician's responsibility extends over periods of years, and his judgements involve consideration of many contingent factors which vary in the course of the disease. In this domain, randomized clinical trials, however ambitious in design, give only partial guidance. Observational data therefore must be used if treatment is to be optimized for individual patients. Two randomized trials in the treatment of narcotics addiction — one testing methadone and the other naltrexone — are reviewed, with comments on their conclusions and limitations.

scholarly journals Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases

2020 ◽  
Vol 21 (21) ◽  
pp. 7870 ◽  
Author(s):  
Francisco Miguel Gutierrez-Mariscal ◽  
Antonio Pablo Arenas-de Larriva ◽  
Laura Limia-Perez ◽  
Juan Luis Romero-Cabrera ◽  
Elena Maria Yubero-Serrano ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Chronic Diseases ◽  
Coenzyme Q10 ◽  
Chronic Obstructive ◽  
Clinical Implications ◽  
Main Function ◽  
Alcoholic Fatty Liver ◽  
Beneficial Effects ◽  
Coq10 Supplementation

Apart from its main function in the mitochondria as a key element in electron transport, Coenzyme Q10 (CoQ10) has been described as having multiple functions, such as oxidant action in the generation of signals and the control of membrane structure and phospholipid and cellular redox status. Among these, the most relevant and most frequently studied function is the potent antioxidant capability of its coexistent redox forms. Different clinical trials have investigated the effect of CoQ10 supplementation and its ability to reduce oxidative stress. In this review, we focused on recent advances in CoQ10 supplementation, its role as an antioxidant, and the clinical implications that this entails in the treatment of chronic diseases, in particular cardiovascular diseases, kidney disease, chronic obstructive pulmonary disease, non-alcoholic fatty liver disease, and neurodegenerative diseases. As an antioxidant, CoQ10 has proved to be of potential use as a treatment in diseases in which oxidative stress is a hallmark, and beneficial effects of CoQ10 have been reported in the treatment of chronic diseases. However, it is crucial to reach a consensus on the optimal dose and the use of different formulations, which vary from ubiquinol or ubiquinone Ubisol-Q10 or Qter®, to new analogues such as MitoQ, before we can draw a clear conclusion about its clinical use. In addition, a major effort must be made to demonstrate its beneficial effects in clinical trials, with a view to making the implementation of CoQ10 possible in clinical practice.

Homeopathic Medicines and Pancreatic Pathology

2017 ◽  
Vol 30 (04) ◽  
pp. 262-267
Author(s):  
Azmal Hossain
Keyword(s):  
Clinical Trials ◽  
Chronic Diseases ◽  
Calcifying Pancreatitis ◽  
Pancreatic Pathology ◽  
Space Occupying Lesion

AbstractIn this article, homeopathic medicines are used to treat a space-occupying lesion and calcifying pancreatitis with calculus. In such deep-seated pathology, low potency medicines produce the desired result and avoid the need for surgery. Wide clinical trials show that some homeopathic medicines are very useful in the treatment of such chronic diseases.

scholarly journals Patient Attitudes and Considerations in Decision toward Participation in Clinical Trials of Chronic Diseases

2017 ◽  
Vol 27 (1) ◽  
pp. 30-37
Author(s):  
Jooyon Yi ◽  
Hongwon Jang ◽  
Jeong-Hyun Yoon ◽  
Sandy Jeong Rhie
Keyword(s):  
Clinical Trials ◽  
Chronic Diseases ◽  
Patient Attitudes

Clinical Trials in Chronic Diseases

1995 ◽  
Vol 35 (6) ◽  
pp. 594-598 ◽  
Author(s):  
Ton J. M. Cleophas ◽  
Piet Tavenier
Keyword(s):  
Clinical Trials ◽  
Chronic Diseases

scholarly journals Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

Foods ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 340 ◽  
Author(s):  
Xiao Meng ◽  
Jing Zhou ◽  
Cai-Ning Zhao ◽  
Ren-You Gan ◽  
Hua-Bin Li
Keyword(s):  
Clinical Trials ◽  
Cardiovascular Diseases ◽  
Chronic Diseases ◽  
Liver Diseases ◽  
Molecular Mechanisms ◽  
Health Benefits ◽  
Experimental Studies ◽  
Bioactive Compound ◽  
Protective Effects ◽  
Epidemiological Surveys

Resveratrol is a bioactive compound in many foods. Since its anticancer activity was reported in 1997, its health benefits have been intensively investigated. Resveratrol has antioxidant, anti-inflammatory, immunomodulatory, glucose and lipid regulatory, neuroprotective, and cardiovascular protective effects, therefore, can protect against diverse chronic diseases, such as cardiovascular diseases (CVDs), cancer, liver diseases, obesity, diabetes, Alzheimer’s disease, and Parkinson’s disease. This review summarizes the main findings of resveratrol-related health benefits in recent epidemiological surveys, experimental studies, and clinical trials, highlighting its related molecular mechanisms. Resveratrol, therefore, has been regarded as a potent candidate for the development of nutraceuticals and pharmaceuticals to prevent and treat certain chronic diseases.

scholarly journals Clinical Trials and Reductionist Approach Preclude Cures for Chronic Diseases Due to Flawed Presumptions

2020 ◽  
Author(s):  
Jianqing Wu ◽  
Ping Zha
Keyword(s):  
Clinical Trials ◽  
Mathematical Models ◽  
Chronic Diseases ◽  
Modern Medicine ◽  
Short Term ◽  
Statistical Population ◽  
Causal Factors ◽  
Synthetic Drugs ◽  
Multiple Process ◽  
Reductionist Approach

Modern medicine adopted four presumptions when it evolved from ancient experienced-based mind-body medicine. To understand its failure in finding cures for chronic diseases, we examined four presumptions, and found that statistical population of health properties does not exist for most research purposes, mathematical models are misused to model intensive properties, synthetic drugs are inherently more dangerous than nature-made medicines under their respective application conditions, and reductionist treatments are inferior and inherently dangerous. We found that clinical trials are valid only for research where treatment effect is much stronger than the total effects of all interfering or co-causal factors or errors introduced by misused mathematical models can be tolerated. In all other situations, clinical trials introduce excessive errors and fail to detect treatment effects, or produce biased, incorrect or wrong results. We further found that chronic diseases are manifestation of small departures in multiple process attributes in distinctive personal biological pathways networks, that modern medicine lacks required accuracy for accurately characterizing chronic diseases, and that reductionist treatments are good at controlling symptoms and safe for short term uses. For all stated reasons, as long as modern medicine continues relying on the flawed presumptions, it can never find predictable cures for chronic diseases. By implication, predictable cures to chronic diseases are adjustments to lifestyle, dietary, emotional, and environmental factors to slowly correct departures in process attributes responsible for chronic diseases.

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