scholarly journals Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells

2021 ◽  
Vol 191 (1) ◽  
pp. 157-167
Author(s):  
Kyle O.C. De La Cena ◽  
Rachel X.-Y. Ho ◽  
Razie Amraei ◽  
Nick Woolf ◽  
Joseph Y. Tashjian ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Cell Cycle Checkpoint ◽  
Colon Cancer Cells ◽  
M Cell ◽  
Putative Tumor Suppressor ◽  
Cycle Checkpoint ◽  
Immunoglobulin Domain

scholarly journals TMIGD1, a Putative Tumor Suppressor, Induces G2-M Cell Cycle Checkpoint Arrest in Colon Cancer Cells

2020 ◽  
Author(s):  
Kyle De La Cena ◽  
Rachel Xi-Yeen Ho ◽  
Razie Amraei ◽  
Nick Woolf ◽  
Joseph Y. Tashjian ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Cell Cycle Checkpoint ◽  
Colon Cancer Cells ◽  
M Cell ◽  
Putative Tumor Suppressor ◽  
Cycle Checkpoint

scholarly journals HRT, Herbal Formula, Induces G2/M Cell Cycle Arrest and Apoptosis via Suppressing Akt Signaling Pathway in Human Colon Cancer Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Nam-Hui Yim ◽  
Won-Kyung Cho ◽  
Ju Hye Lee ◽  
Young Pil Jung ◽  
Hye Jin Yang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
M Cell ◽  
Human Colon Cancer ◽  
Cycle Arrest

We have demonstrated the anticancer effect of HRT in HCT116, human colon carcinoma cells. HRT inhibited cancer cell growth by causing cell cycle arrest at G2/M and inducing apoptosis as evidenced by DNA fragmentation assay. We found that HRT induces the activation of caspase-3, -8, and -9, whereas it reduces the level of Bcl-2 protein and results in the cleavage of PARP. Further, HRT decreased the level of phosphorylation of Akt and its downstream signals such as mTOR and GSK-3β. These results indicate that HRT stimulates the apoptotic signaling pathway and represses the survival and proliferation of colon cancer cells via inhibiting Akt activity. Hence, our results suggest that HRT has a potential to be developed as a therapeutic agent against colon cancer cells.

Sign in / Sign up

Export Citation Format

Share Document