scholarly journals Corneal Opacity Induced by Light in a Mouse Model of Gelatinous Drop-Like Corneal Dystrophy

2020 ◽  
Vol 190 (12) ◽  
pp. 2330-2342
Author(s):  
Yukiko Nagahara ◽  
Motokazu Tsujikawa ◽  
Ryota Koto ◽  
Koji Uesugi ◽  
Shigeru Sato ◽  
...  
Keyword(s):  
Mouse Model ◽  
Corneal Opacity ◽  
Corneal Dystrophy

U-Net Convolutional Neural Network for Segmenting the Corneal Endothelium in a Mouse Model of Fuchs Endothelial Corneal Dystrophy

Cornea ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Naoki Okumura ◽  
Shohei Yamada ◽  
Takeru Nishikawa ◽  
Kaito Narimoto ◽  
Kengo Okamura ◽  
...  
Keyword(s):  
Neural Network ◽  
Mouse Model ◽  
Convolutional Neural Network ◽  
Corneal Endothelium ◽  
Corneal Dystrophy

scholarly journals Indications for keratoplasty in Nepal: 2005 - 2010

2013 ◽  
Vol 5 (2) ◽  
pp. 207-214 ◽  
Author(s):  
Leena Bajracharya ◽  
R Gurung ◽  
EH DeMarchis ◽  
M Oliva ◽  
S Ruit ◽  
...  
Keyword(s):  
Case Series ◽  
Corneal Opacity ◽  
Corneal Dystrophy ◽  
Bullous Keratopathy ◽  
Infectious Keratitis ◽  
Eye Health ◽  
Corneal Scar ◽  
Recipient Age ◽  
Corneal Opacities ◽  
Corneal Blindness

Introduction: Corneal disease, especially infective keratitis, is one of the major causes of visual impairment and blindness in developing countries. Objective: To find out the current indications for keratoplasty, how these indications have changed over time as well as how they are different from those in other parts of the world. Materials and methods: A retrospective study of a case series of 645 keratoplasty surgeries (589 patients) was conducted at the Tilganga Institute of Ophthalmology from January 2005 to December 2010. Outcome measures: The cases were evaluated in terms of demographic parameters, preoperative diagnosis and the type of surgery performed. Results: The most common indication for surgery was active infectious keratitis (264 eyes, 40.9 %), followed by corneal opacity (173 eyes, 26.8 %), regraft (73 eyes, 11.2 %), bullous keratopathy (58 eyes, 9.0 %), keratoconus (45 eyes, 7.0 %) and corneal dystrophy (11 eyes, 1.7 %). The mean recipient age was 41.7 ± 19.9 years with over a half of the patients between 15 to 49 years of age. More men (64.1 %) underwent keratoplasty than women (35.8 %). 59.8 % of the eyes with infectious keratitis had a perforated corneal ulcer. 49.7 % of corneal opacities were due to previous infectious keratitis. 72 % of regrafts were for endothelial failure of various causes. In older patients (> 50 years), bullous keratopathy was an important indication, after infectious keratitis. Keratoconus and corneal scar were major causes of keratoplasty in children of 14 years or less. Four percent of the patients had keratoplasty in both the eyes. 17.1 % of the patients who had one eye operated on had a blind fellow eye with a vision of less than 3/60. Conclusion: Currently, keratitis, either active or healed, is the major indication for keratoplasty, suggesting that improved primary eye health care is necessary to decrease the prevalence of corneal blindness. Nepal J Ophthalmol 2013; 5(10): 207-214 DOI: http://dx.doi.org/10.3126/nepjoph.v5i2.8730

Corneal Dystrophy in Dutch Belted Rabbits as a Possible Model of Thiel-Behnke Subtype of Epithelial-Stromal TGFβ-Induced Corneal Dystrophy

2020 ◽  
pp. 019262332096809
Author(s):  
JoAnn C. L. Schuh ◽  
Dana L. Holve ◽  
Karen E. Mundwiler
Keyword(s):  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Corneal Opacity ◽  
Corneal Dystrophy ◽  
International Committee ◽  
Corneal Dystrophies ◽  
Transmission Electron ◽  
Oct Imaging ◽  
Small Clusters

The International Committee for Classification of Corneal Dystrophies (IC3D) categorized corneal dystrophies in humans using anatomic, genotypic, and clinicopathologic phenotypic features. Relative to the IC3D classification, a review of the veterinary literature confirmed that corneal dystrophy is imprecisely applied to any corneal opacity and to multiple poorly characterized histologic abnormalities of the cornea in animals. True corneal dystrophy occurs in mice with targeted mutations and spontaneously in pet dogs and cats and in Dutch belted (DB) rabbits, but these instances lack complete phenotyping or genotyping. Corneal dystrophy in DB rabbits can be an important confounding finding in ocular toxicology studies but has only been described once. Therefore, the ophthalmology and pathology of corneal dystrophy in 13 DB rabbits were characterized to determine whether the findings were consistent with or a possible model of any corneal dystrophy subtypes in humans. Slit lamp and optical coherence tomography (OCT) imaging were used to characterize corneal dystrophy over 4 months in young DB rabbits. The hyperechoic OCT changes correlated with light microscopic findings in the anterior stroma, consisting of highly disordered collagen fibers and enlarged keratocytes. Histochemical stains did not reveal abnormal deposits. Small clusters of 8 to 16 nm diameter curly fibers identified by transmission electron microscopy were consistent with Thiel-Behnke (TBCD) subtype of epithelial-stromal transforming growth factor β-induced dystrophies. Sporadic corneal dystrophy in DB rabbits appears to be a potential animal model of TBCD, but genotypic characterization will be required to confirm this categorization.

scholarly journals Generation of mouse model of TGFBI-R124C corneal dystrophy using CRISPR/Cas9-mediated homology-directed repair

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kohdai Kitamoto ◽  
Yukako Taketani ◽  
Wataru Fujii ◽  
Aya Inamochi ◽  
Tetsuya Toyono ◽  
...  
Keyword(s):  
Mouse Model ◽  
Corneal Dystrophy ◽  
Homology Directed Repair

scholarly journals EndothelialCdkn1a(p21) Overexpression and Accelerated Senescence in a Mouse Model of Fuchs Endothelial Corneal Dystrophy

2012 ◽  
Vol 53 (10) ◽  
pp. 6718 ◽  
Author(s):  
Mario Matthaei ◽  
Huan Meng ◽  
Alan K. Meeker ◽  
Charles G. Eberhart ◽  
Albert S. Jun
Keyword(s):  
Mouse Model ◽  
Corneal Dystrophy ◽  
Accelerated Senescence

scholarly journals A Mouse Model of Schnyder Corneal Dystrophy with the N100S Point Mutation

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Fei Dong ◽  
Xueting Jin ◽  
Michelle A. Boettler ◽  
Harrison Sciulli ◽  
Mones Abu-Asab ◽  
...  
Keyword(s):  
Mouse Model ◽  
Point Mutation ◽  
Corneal Dystrophy ◽  
Schnyder Corneal Dystrophy

scholarly journals Protein Analysis of the TGFBI R124H Mouse Model Gives Insight into Phenotype Development of Granular Corneal Dystrophy

2020 ◽  
Vol 14 (6) ◽  
pp. 1900072
Author(s):  
Marie V. Lukassen ◽  
Ebbe T. Poulsen ◽  
Jack Donaghy ◽  
Emilie H. Mogensen ◽  
Kathleen A. Christie ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protein Analysis ◽  
Corneal Dystrophy ◽  
Granular Corneal Dystrophy ◽  
Insight Into

scholarly journals Analysis of causes and outcomes of corneal transplantation in al-zahra eye hospital in southeast of Iran from 2011-2016

2017 ◽  
Vol 5 (7) ◽  
pp. 2917
Author(s):  
Behrouz Dehghan ◽  
Mohammadnaeem Aminifard ◽  
Zahra Raisi
Keyword(s):  
Transplant Rejection ◽  
Corneal Transplantation ◽  
Organ Transplant ◽  
Corneal Opacity ◽  
Corneal Dystrophy ◽  
Bullous Keratopathy ◽  
Corneal Transplant ◽  
Term Care ◽  
Corneal Scar

Background: Corneal transplantation is known as the most successful and common type of organ transplant, but it calls for more intensive and long-term care. Given the lack of adequate information on this important surgery in this province and the differences between indications and causes of corneal transplantation, the present research was carried out to examine the causes and outcomes of corneal transplant in patients visiting Al-Zahra eye hospital who had received donated cornea in the past five years.Methods: In a retrospective analytical-descriptive study 135 files of 149 eyes that had gone through corneal transplantation were examined. Information on the age, gender, residence, indications, and surgery consequences was extracted and was analyzed in SPSS 19 statistical software with descriptive statistics (percentage, frequency, mean, and standard deviation.Results: The highest transplant indication was keratoconus with a frequency of 39.9% followed by bullous keratopathy, corneal opacity, and transplant rejection with frequencies of 16.1, 12.7, and 10.1%, respectively. Other indications were corneal scar (9.4%), corneal perforation (2.7%), trauma (2.7%), and Fuchs’ corneal dystrophy (1.3%) in the order mentioned. Concerning postoperative complications in this research, 57.7% of the eyes (86 cases) showed no complication. Moreover, complications were mostly related to astigmatism with a frequency of 30.8% (46 cases).Conclusions: In general, the most common indication in this research was keratoconus. Most surgeries were also complication-free and most complications were associated with astigmatism.

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