scholarly journals Experimental Study Using Multiple Strains of Prion Disease in Cattle Reveals an Inverse Relationship between Incubation Time and Misfolded Prion Accumulation, Neuroinflammation, and Autophagy

2020 ◽  
Vol 190 (7) ◽  
pp. 1461-1473 ◽  
Author(s):  
Najiba Mammadova ◽  
M. Heather West Greenlee ◽  
S. Jo Moore ◽  
Donald S. Sakaguchi ◽  
Justin J. Greenlee
Keyword(s):  
Experimental Study ◽  
Prion Disease ◽  
Incubation Time ◽  
Inverse Relationship ◽  
Multiple Strains

scholarly journals Sod1 Deficiency Reduces Incubation Time in Mouse Models of Prion Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e54454 ◽  
Author(s):  
Shaheen Akhtar ◽  
Julia Grizenkova ◽  
Adam Wenborn ◽  
Holger Hummerich ◽  
Mar Fernandez de Marco ◽  
...  
Keyword(s):  
Mouse Models ◽  
Prion Disease ◽  
Incubation Time

Prion disease incubation time is not affected in mice heterozygous for a dynein mutation

2004 ◽  
Vol 326 (1) ◽  
pp. 18-22 ◽  
Author(s):  
Majid Hafezparast ◽  
Sebastian Brandner ◽  
Jackie Linehan ◽  
Joanne E. Martin ◽  
John Collinge ◽  
...  
Keyword(s):  
Prion Disease ◽  
Incubation Time

scholarly journals Microglial Cx3cr1 knockout reduces prion disease incubation time in mice

2014 ◽  
Vol 15 (1) ◽  
pp. 44 ◽  
Author(s):  
Julia Grizenkova ◽  
Shaheen Akhtar ◽  
Sebastian Brandner ◽  
John Collinge ◽  
Sarah E Lloyd
Keyword(s):  
Prion Disease ◽  
Incubation Time

Mechanical recanalization for clot occlusion of venous access ports: experimental study using ports with clot occlusion

2017 ◽  
Vol 18 (2) ◽  
pp. 158-162
Author(s):  
Myung Gyu Song ◽  
Tae-Seok Seo ◽  
Baek-hui Kim ◽  
Jeong Ho Kim
Keyword(s):  
Experimental Study ◽  
Histological Examination ◽  
Clinical Application ◽  
Incubation Time ◽  
Venous Access ◽  
Mechanical Recanalization ◽  
Occlusion Model ◽  
Similar Appearance ◽  
Mechanical Injection ◽  
Time Point

Purpose To test the hypothesis that mechanical injection of saline is safe and effective in restoring patency of totally implantable venous access ports (TIVAPs) with clot occlusion. We devised an experimental port model for the evaluation of mechanical TIVAP recanalization prior to its clinical application. Materials and Methods The clot TIVAP occlusion model was constructed by filling the catheter with swine blood and incubating it at 37.5°C. The model was incubated for different lengths of time ranging from 1 day to 7 days. Each incubation time point included 20 ports. Total catheter occlusion of the TIVAPs was assessed with a 10-mL saline syringe equipped with a non-coring needle. Occlusion was defined as no passage of saline through the catheter when it was aspirated and infused gently with the 10-mL saline syringe. Pressure was evaluated during recanalization with an indeflator. Histological examination was performed on the clot obtained during recanalization. Results Among the 140 total experimental ports, 65 occlusions (46.4%) were detected. Of these 65 occlusions, 56 (86.1%) were recanalized by mechanical saline pressure via the indeflator. The indeflator pressure ranged from 29 pound per square-inch (psi) to 265 psi at mechanical catheter recanalization (mean: 110 psi). Histologically, all specimens from the model ports exhibited a similar appearance; specifically, erythrocytes, cells, and fibrin were evenly scattered throughout the clot. Conclusions Our data indicate that it is feasible to generate a TIVAP clot occlusion model with swine blood. Moreover, mechanical recanalization was suitable for resolving occluded catheters without thrombolytic agents.

scholarly journals Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models

2019 ◽  
Vol 189 (3) ◽  
pp. 677-686
Author(s):  
Atsushi Kobayashi ◽  
Zechen Qi ◽  
Taishi Shimazaki ◽  
Yoshiko Munesue ◽  
Tomomi Miyamoto ◽  
...  
Keyword(s):  
Mouse Models ◽  
Prion Disease ◽  
Incubation Time

Telescope Field of View Requirements for Star Recognition

1966 ◽  
Vol 8 (1) ◽  
pp. 41-47
Author(s):  
R. W. Allen ◽  
M. L. Hershberger
Keyword(s):  
Experimental Study ◽  
Los Angeles ◽  
Air Force ◽  
Inverse Relationship ◽  
Field Of View ◽  
Human Recognition ◽  
Significant Inverse Relationship ◽  
Identification Time ◽  
Star Identification ◽  
Hughes Aircraft

An experimental study was conducted by Hughes Aircraft Company to determine telescope field of view requirements for human recognition of navigation stars. The study was conducted at the Griffith Park Planetarium in Los Angeles. Four Air Force navigators viewed the night sky projected on the planetarium dome through a simulated telescope. The subjects had control of telescope azimuth and elevation. The telescope had unity power fields of view ranging between 10 and 45 degrees. The subjects were required to identify and acquire any one of the 35 major navigation stars. The results revealed a significant inverse relationship between field of view size and navigation star acquisition-identification time. Identification errors also varied inversely as a function of field of view size, and mean acquisition-identification times were significantly different between subjects. The minimum field of view required for rapid, accurate star identification-acquisition was established to be between 25 and 30 degrees.

scholarly journals Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice

2012 ◽  
Vol 109 (34) ◽  
pp. 13722-13727 ◽  
Author(s):  
J. Grizenkova ◽  
S. Akhtar ◽  
H. Hummerich ◽  
A. Tomlinson ◽  
E. A. Asante ◽  
...  
Keyword(s):  
Prion Disease ◽  
Incubation Time

Inhibition of P53-related apoptosis had no effect on PrPSc accumulation and prion disease incubation time

2005 ◽  
Vol 18 (2) ◽  
pp. 282-285 ◽  
Author(s):  
Roni Engelstein ◽  
Nikolas Grigoriadis ◽  
Nigel H. Greig ◽  
Haim Ovadia ◽  
Ruth Gabizon
Keyword(s):  
Prion Disease ◽  
Incubation Time

scholarly journals Shadoo (Sprn) and prion disease incubation time in mice

2009 ◽  
Vol 20 (6) ◽  
pp. 367-374 ◽  
Author(s):  
Sarah E. Lloyd ◽  
Julia Grizenkova ◽  
Hirva Pota ◽  
John Collinge
Keyword(s):  
Prion Disease ◽  
Incubation Time

Bottom-up biofilm eradication using bacteriophage-loaded magnetic nanocomposites: a computational and experimental study

2019 ◽  
Vol 6 (12) ◽  
pp. 3539-3550 ◽  
Author(s):  
Pingfeng Yu ◽  
Zijian Wang ◽  
Mariana Marcos-Hernandez ◽  
Pengxiao Zuo ◽  
Danning Zhang ◽  
...  
Keyword(s):  
Experimental Study ◽  
Inverse Relationship ◽  
Computational Study ◽  
Magnetic Nanocomposites ◽  
Bottom Up

The combined experimental and computational study demonstrates an inverse relationship between phage-nanocomposite conjugate (PNC) size and biofilm eradication potential.

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