scholarly journals Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin–Receptor Activity–Modifying Protein 2 System

2019 ◽  
Vol 189 (2) ◽  
pp. 449-466 ◽  
Author(s):  
Kazutaka Hirabayashi ◽  
Masaaki Tanaka ◽  
Akira Imai ◽  
Yuichi Toriyama ◽  
Yasuhiro Iesato ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Vascular Occlusion ◽  
Receptor Activity ◽  
Retinal Vascular Occlusion ◽  
Adrenomedullin Receptor ◽  
Novel Model

scholarly journals Baicalein, Baicalin, and Wogonin: Protective Effects against Ischemia-Induced Neurodegeneration in the Brain and Retina

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Li Pan ◽  
Kin-Sang Cho ◽  
Irvin Yi ◽  
Chi-Ho To ◽  
Dong Feng Chen ◽  
...  
Keyword(s):  
Time Window ◽  
Therapeutic Potential ◽  
Vascular Dysfunction ◽  
Pathological Condition ◽  
Vascular Occlusion ◽  
Protective Effects ◽  
Scutellaria Baicalensis Georgi ◽  
Retinal Vascular Occlusion ◽  
Low Cytotoxicity ◽  
The Brain

Ischemia is a common pathological condition present in many neurodegenerative diseases, including ischemic stroke, retinal vascular occlusion, diabetic retinopathy, and glaucoma, threatening the sight and lives of millions of people globally. Ischemia can trigger excessive oxidative stress, inflammation, and vascular dysfunction, leading to the disruption of tissue homeostasis and, ultimately, cell death. Current therapies are very limited and have a narrow time window for effective treatment. Thus, there is an urgent need to develop more effective therapeutic options for ischemia-induced neural injuries. With emerging reports on the pharmacological properties of natural flavonoids, these compounds present potent antioxidative, anti-inflammatory, and antiapoptotic agents for the treatment of ischemic insults. Three major active flavonoids, baicalein, baicalin, and wogonin, have been extracted from Scutellaria baicalensis Georgi (S. baicalensis); all of which are reported to have low cytotoxicity. They have been demonstrated to exert promising pharmacological capabilities in preventing cell and tissue damage. This review focuses on the therapeutic potentials of these flavonoids against ischemia-induced neurotoxicity and damage in the brain and retina. The bioactivity and bioavailability of baicalein, baicalin, and wogonin are also discussed. It is with hope that the therapeutic potential of these flavonoids can be utilized and developed as natural treatments for ischemia-induced injuries of the central nervous system (CNS).

Age, Gender, and Laterality of Retinal Vascular Occlusion: A Retrospective Study from the IRIS® Registry

2021 ◽  
Author(s):  
Yangjiani Li ◽  
Nathan E. Hall ◽  
Suzann Pershing ◽  
Leslie Hyman ◽  
Julia A. Haller ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Vascular Occlusion ◽  
Retinal Vascular Occlusion

Retinal obliterative vasculitis associated to contralateral retinal neovascularization in membranoproliferative glomerulonephritis

2021 ◽  
pp. 112067212110143
Author(s):  
Michele Nicolai ◽  
Alessandro Franceschi ◽  
Nicola Vito Lassandro ◽  
Paolo Pelliccioni ◽  
Luca Danieli ◽  
...  
Keyword(s):  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Membranoproliferative Glomerulonephritis ◽  
Vision Loss ◽  
Vascular Occlusion ◽  
Retinal Neovascularization ◽  
Vein Occlusion ◽  
Retinal Vascular Occlusion ◽  
Contralateral Eye ◽  
Peculiar Case

Purpose: To report our experience with a peculiar case of asynchronous bilateral retinal vascular occlusion in a patient suffering from membranoproliferative glomerulonephritis. Case report: A 57-year-old dialysed male affected by membranoproliferative glomerulonephritis who underwent kidney transplantation complained of a sudden vision loss in his right eye (RE). His best-corrected visual acuity (BCVA) was 20/40 in RE and 20/20 in the left eye (LE); ophthalmological and fluorangiographic examinations revealed unilateral retinal obliterative vasculitis with panuveitis and apparent sparing of contralateral eye. About 6 months later the patient developed a branch retinal vein occlusion associated with a papillary neovascular membrane in LE. Corticosteroid therapy was administered and immunosuppressant dosage was increased with macular oedema reduction in both events. Conclusion: We report a case of unilateral retinal obliterative vasculitis and subsequent contralateral retinal neovascularization and branch retinal vein occlusion in a patient affected by membranoproliferative glomerulonephritis.

scholarly journals Suspected Gentamicin-Induced Retinal Vascular Occlusion after Vitrectomy

2020 ◽  
Vol 11 (2) ◽  
pp. 473-480 ◽  
Author(s):  
Fumiko Murao ◽  
Takamasa Kinoshita ◽  
Takashi Katome ◽  
Hiroki Sano ◽  
Masanori Niki ◽  
...  
Keyword(s):  
Vascular Occlusion ◽  
Perioperative Period ◽  
Retinal Hemorrhage ◽  
Optic Disk ◽  
Subconjunctival Injection ◽  
Ocular Surgery ◽  
Gas Tamponade ◽  
Retinal Vascular Occlusion ◽  
The Right ◽  
Arteries And Veins

Retinal vascular occlusion after ocular surgery is a rare but serious complication. A history of cardiovascular diseases, retrobulbar anesthesia injection, high intraocular pressure during the perioperative period, and drug toxicity have been reported as possible causative factors. We report here two cases of multiple retinal vascular occlusions after the subconjunctival injection of gentamicin at the end of uncomplicated 25-gauge vitrectomy. Case 1 was a 61-year-old man who developed a macular hole in the right eye. Phacovitrectomy with gas tamponade was performed. On postoperative day (POD) 1, dot hemorrhage was observed on the temporal side of the optic disk. On POD10, macular whitening, retinal hemorrhage, and multiple occlusion of retinal arteries and veins were observed. Case 2 was a 51-year-old woman who was diagnosed with rhegmatogenous retinal detachment in the right eye and underwent phacovitrectomy with gas tamponade. On POD3, macular whitening with cotton wool spots and retinal hemorrhage were observed with macular ischemia owing to occlusion of retinal arteries and veins. In both cases, subconjunctival injection of gentamicin given at the end of surgery was the most suspected cause of retinal vascular occlusion.

OCT based interpretation of the optic nerve head anatomy in young adults with retinal vascular occlusions and ischemic optic neuropathy

2020 ◽  
pp. 112067212095759
Author(s):  
Amy Dai ◽  
Lasse Malmqvist ◽  
Simon P Rothenbuehler ◽  
Steffen Hamann
Keyword(s):  
Young Adults ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Vascular Occlusion ◽  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Ischemic Optic Neuropathy ◽  
Vein Occlusion ◽  
Retinal Vascular Occlusion ◽  
Retinal Artery

Purpose: To examine optic nerve head (ONH) anatomy in young adults with central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), central retinal artery occlusion (CRAO), branch retinal artery occlusion (BRAO) or nonarteritic anterior ischemic optic neuropathy (NA-AION) in order to look for associated, potentially predisposing anomalies. Methods: Cross-sectional study including 54 patients (ages 16–50 years) diagnosed from 2009 to 2018 with CRVO, BRVO, CRAO, BRAO, or NA-AION. Using Optical Coherence Tomography the presence of optic disc drusen (ODD), prelaminar hyperreflective lines and peripapillary hyperreflective ovoid mass-like structures (PHOMS), and determination of scleral canal size, retinal nerve fiber layer thickness (RNFLT) and macular ganglion cell layer thickness (GCLT) was obtained. Data for retinal vascular occlusion patients were grouped and analyzed together. Results: ODD were found in 13% of all patients, 2% of retinal vascular occlusion patients and 67% of NA-AION patients ( p < 0.0001). Prelaminar hyperreflective lines were found in 35% of all patients, 24% of retinal vascular occlusion patients and 89% of NA-AION patients ( p = 0.0005). PHOMS were found in 20% of all patients, 13% of retinal vascular occlusion patients and 56% of NA-AION patients ( p = 0.012). RNFLT was decreased in ODD patients compared to patients without ODD ( p = 0.01). Scleral canal diameter and GCLT was not correlated with ODD, prelaminar hyperreflective lines or PHOMS. Conclusion: ODD, prelaminar hyperreflective lines and PHOMS were more frequent in NA-AION patients compared to retinal vascular occlusion patients. The prevalence of ODD in retinal vascular occlusion patients was similar to the reported prevalence in the general population.

Retinal vascular occlusion following ocular contusion

2004 ◽  
Vol 243 (5) ◽  
pp. 406-409 ◽  
Author(s):  
José Dalma-Weiszhausz ◽  
Armando Meza-de Regil ◽  
Susana Martínez-Jardón ◽  
Katia Oliver-Fernández
Keyword(s):  
Vascular Occlusion ◽  
Retinal Vascular Occlusion ◽  
Ocular Contusion

Central Retinal Vascular Occlusion Associated with Oral Contraceptives

1978 ◽  
Vol 86 (6) ◽  
pp. 798-801 ◽  
Author(s):  
G.Cleveland Stowe ◽  
Z.Nicholas Zakov ◽  
Daniel M. Albert
Keyword(s):  
Oral Contraceptives ◽  
Vascular Occlusion ◽  
Retinal Vascular Occlusion
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