scholarly journals Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice

2018 ◽  
Vol 188 (7) ◽  
pp. 1640-1652 ◽  
Author(s):  
Li Q. Zhang ◽  
Marianne Nsumu ◽  
Peixin Huang ◽  
Daniel P. Heruth ◽  
Sean M. Riordan ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Protective Role ◽  
Nicotinamide Phosphoribosyltransferase

A protective role of IL-22BP in acute liver injury

2017 ◽  
Vol 66 (1) ◽  
pp. S333-S334
Author(s):  
D. Kleinschmidt ◽  
A.D. Giannou ◽  
J. Kempski ◽  
B. Steglich ◽  
F.J. Huber ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Protective Role

Nicotinamide improves NAD+ levels to protect against acetaminophen-induced acute liver injury in mice

2021 ◽  
pp. 096032712110145
Author(s):  
J Xu ◽  
L Zhang ◽  
R Jiang ◽  
K Hu ◽  
D Hu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Related Factor ◽  
Dependent Manner ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Apap Overdose ◽  
Hepatoprotective Effects ◽  
Dose Dependent ◽  
Different Doses

Acetaminophen (APAP) overdose causes acute liver injury (ALI). Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme, and NAD+ is oxidized type which synthesized from nicotinamide (NAM). The present study aimed to investigate the role of NAD+ in ALI and protective property of NAM. The mice were subjected to different doses APAP. After 8 hours, the serum activities of alaninetransaminase (ALT) and aspartate aminotransferase (AST), the hepatic NAD+ level and nicotinamide phosphoribosyltransferase (NAMPT) expression were determined. Then, the mice were pretreated with NAM (800 mg/kg), the hepatoprotective effects and the key antioxidative molecules were evaluated. Our findings indicated that APAP resulted in remarkable NAD+ depletion in a dose-dependent manner accompanied by NAMPT downregulation, and NAM pretreatment significantly elevated the NAD+ decline due to upregulation of NAMPT. Moreover, the downregulated Kelch-like ECH-associated protein-1 (Keap1), upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) and its translocation activation after NAM administration were confirmed, which were in accordance with improved superoxide dismutase (SOD) and glutathione (GSH) levels. Finally, NAM dramatically exhibited hepatoprotective effects by reducing the liver index and necrotic area. This study has suggested that APAP impairs liver NAD+ level and NAM is able to improve hepatic NAD+ to activate antioxidant pathway against APAP-induced ALI.

Protective role of c‐Jun N‐terminal kinase‐2 (JNK2) in ibuprofen‐induced acute liver injury

2018 ◽  
Author(s):  
Miguel E Zoubek ◽  
Marius M Woitok ◽  
Svenja Sydor ◽  
Leonard J Nelson ◽  
Lars P Bechmann ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Protective Role

scholarly journals Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Luciano Rezende Vilela ◽  
Lindisley Ferreira Gomides ◽  
Bruna Araújo David ◽  
Maísa Mota Antunes ◽  
Ariane Barros Diniz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Damage ◽  
Acute Liver Injury ◽  
Endocannabinoid System ◽  
Protective Role ◽  
Acute Liver Damage ◽  
Protective Actions ◽  
Cocaine Toxicity ◽  
Hepatotoxic Drug

Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate. Considering the protective role of the endocannabinoid system against cell toxicity, we hypothesized that treatment with an anandamide hydrolysis inhibitor, URB597, or with a phytocannabinoid, cannabidiol (CBD), protects against cocaine toxicity. URB597 (1.0 mg/kg) abolished cocaine-induced seizure, yet it did not protect against acute liver injury. Using confocal liver intravital microscopy, we observed that CBD (30 mg/kg) reduced acute liver inflammation and damage induced by cocaine and prevented associated seizure. Additionally, we showed that previous liver damage induced by another hepatotoxic drug (acetaminophen) increased seizure and lethality induced by cocaine intoxication, linking hepatotoxicity to seizure dynamics. These findings suggest that activation of cannabinoid system may have protective actions on both liver and brain induced by cocaine, minimizing inflammatory injury promoted by cocaine, supporting its further clinical application in the treatment of cocaine abuse.

scholarly journals The role of non-steroidal anti-inflammatory drugs in acute liver injury.

BMJ ◽  
1992 ◽  
Vol 305 (6858) ◽  
pp. 865-868 ◽  
Author(s):  
L. A. Garcia Rodriguez ◽  
S. Perez Gutthann ◽  
A. M. Walker ◽  
L. Lueck
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

A Protective Role of Okadaic Acid in Liver Injury Induced by Amoxicillin

2022 ◽  
Author(s):  
D. Li ◽  
W. Shi ◽  
X. Lu ◽  
Z. Liu ◽  
S. Zhang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Okadaic Acid ◽  
Protective Role
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