scholarly journals Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells

2018 ◽  
Vol 188 (5) ◽  
pp. 1161-1170 ◽  
Author(s):  
Li-Yin Hung ◽  
Taylor K. Oniskey ◽  
Debasish Sen ◽  
Matthew F. Krummel ◽  
Andrew E. Vaughan ◽  
...  
Keyword(s):  
Trefoil Factor ◽  
Lung Repair ◽  
Type 2 Immunity ◽  
Intrinsic Roles ◽  
Trefoil Factor 2

scholarly journals Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection

2012 ◽  
Vol 209 (3) ◽  
pp. 607-622 ◽  
Author(s):  
Marsha Wills-Karp ◽  
Reena Rani ◽  
Krista Dienger ◽  
Ian Lewkowich ◽  
James G. Fox ◽  
...  
Keyword(s):  
Messenger Rna ◽  
Molecular Mechanisms ◽  
Nippostrongylus Brasiliensis ◽  
Trefoil Factor ◽  
Interleukin 33 ◽  
Parasitic Helminths ◽  
Type 2 Immunity ◽  
Th2 Responses ◽  
Trefoil Factor 2

The molecular mechanisms that drive mucosal T helper type 2 (TH2) responses against parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell–derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection. TFF2 is also necessary for the rapid production of IL-33, a TH2-promoting cytokine, by lung epithelia, alveolar macrophages, and inflammatory dendritic cells in infected mice. TFF2 also increases the severity of allergic lung disease caused by house dust mite antigens or IL-13. Moreover, TFF2 messenger RNA expression is significantly increased in nasal mucosal brushings during asthma exacerbations in children. These experiments extend the biological functions of TFF2 from tissue repair to the initiation and maintenance of mucosal TH2 responses.

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