scholarly journals Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts

2018 ◽  
Vol 188 (1) ◽  
pp. 216-228 ◽  
Author(s):  
Matias Knuuttila ◽  
Arfa Mehmood ◽  
Riikka Huhtaniemi ◽  
Emrah Yatkin ◽  
Merja R. Häkkinen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant

scholarly journals Gene amplification of YB‐1 in castration‐resistant prostate cancer in association with aberrant androgen receptor expression

2020 ◽  
Vol 112 (1) ◽  
pp. 323-330
Author(s):  
Masaki Shiota ◽  
Yohei Sekino ◽  
Shigehiro Tsukahara ◽  
Tatsuro Abe ◽  
Fumio Kinoshita ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Gene Amplification ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant

Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expression

2011 ◽  
Vol 18 (4) ◽  
pp. 505-517 ◽  
Author(s):  
Masaki Shiota ◽  
Ario Takeuchi ◽  
YooHyun Song ◽  
Akira Yokomizo ◽  
Eiji Kashiwagi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cell Growth ◽  
Therapeutic Potential ◽  
Binding Protein ◽  
Receptor Expression ◽  
Transcriptional Level ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistance ◽  
Castration Resistant

The androgen receptor (AR) is well known to play a central role in the pathogenesis of prostate cancer (PCa). In several studies, AR was overexpressed in castration-resistant PCa (CRPC). However, the mechanism of AR overexpression in CRPC is not fully elucidated. Y-box binding protein-1 (YB-1) is a pleiotropic transcription factor that is upregulated in CPRC. We aimed to elucidate the role of YB-1 in castration resistance of PCa and identify therapeutic potential of targeting YB-1. Using immunohistochemistry, we found that nuclear YB-1 expression significantly correlated with the Gleason score and AR expression in PCa tissues. In PCa cells, YB-1 regulated AR expression at the transcriptional level. Furthermore, YB-1 expression and nuclear localization were upregulated in CRPC cells. Overexpression of AR, as well as YB-1, conferred castration-resistant growth in LNCaP and 22Rv1 cells. Conversely, knocking down YB-1 resulted in suppressed cell growth and induced apoptosis, which was more efficient than knocking down AR in LNCaP cells. In other types of PCa cells, such as CRPC cells, knocking down YB-1 resulted in a significant reduction of cell growth. In conclusion, these findings suggested that YB-1 induces castration resistance in androgen-dependent PCa cells via AR expression. Thus, YB-1 may be a promising therapeutic target for PCa, as well as CRPC.

scholarly journals Interplay Between SOX9, Wnt/β-Catenin and Androgen Receptor Signaling in Castration-Resistant Prostate Cancer

2019 ◽  
Vol 20 (9) ◽  
pp. 2066 ◽  
Author(s):  
Namrata Khurana ◽  
Suresh C. Sikka
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Signaling Pathways ◽  
Critical Role ◽  
Castration Resistant Prostate Cancer ◽  
Form Complex ◽  
Androgen Receptor Signaling ◽  
Castration Resistant ◽  
Signaling Axis

Androgen receptor (AR) signaling plays a key role not only in the initiation of prostate cancer (PCa) but also in its transition to aggressive and invasive castration-resistant prostate cancer (CRPC). However, the crosstalk of AR with other signaling pathways contributes significantly to the emergence and growth of CRPC. Wnt/β-catenin signaling facilitates ductal morphogenesis in fetal prostate and its anomalous expression has been linked with PCa. β-catenin has also been reported to form complex with AR and thus augment AR signaling in PCa. The transcription factor SOX9 has been shown to be the driving force of aggressive and invasive PCa cells and regulate AR expression in PCa cells. Furthermore, SOX9 has also been shown to propel PCa by the reactivation of Wnt/β-catenin signaling. In this review, we discuss the critical role of SOX9/AR/Wnt/β-catenin signaling axis in the development and progression of CRPC. The phytochemicals like sulforaphane and curcumin that can concurrently target SOX9, AR and Wnt/β-catenin signaling pathways in PCa may thus be beneficial in the chemoprevention of PCa.

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