Mouse Osteoblasts Play a Crucial Role in the Immune System

2016 ◽  
Vol 186 (5) ◽  
pp. 1078-1080
Author(s):  
Shigeru Kotake ◽  
Yuki Nanke
Keyword(s):  
Immune System ◽  
Crucial Role

Indole based prostate cancer agents

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Sunil Kumar ◽  
Madhuri T. Patil ◽  
Deepak B. Salunke
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Lung Cancer ◽  
Immune System ◽  
Anticancer Agents ◽  
Crucial Role ◽  
Heterocyclic Compounds ◽  
Indole Derivatives ◽  
Cancer Chemotherapeutics ◽  
Privileged Structure

Abstract Cancer weakens the immune system which fails to fight against the rapidly growing cells. Among the various types of cancers, prostate cancer (PCa) is causing greater number of deaths in men after lung cancer, demanding advancement to prevent, detect and treat PCa. Several small molecule heterocycles and few peptides are being used as oncological drugs targeting PCa. Heterocycles are playing crucial role in the development of novel cancer chemotherapeutics as well as immunotherapeutics. Indole skeleton, being a privileged structure has been extensively used for the discovery of novel anticancer agents and the application of indole derivatives against breast cancer is well documented. The present article highlights the usefulness of indole linked heterocyclic compounds as well as the fused indole derivatives against prostate cancer.

scholarly journals Therapeutic Interventions into Innate Immune Diseases by Means of Aptamers

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 955
Author(s):  
Farzana Yasmeen ◽  
Hana Seo ◽  
Nasir Javaid ◽  
Moon Suk Kim ◽  
Sangdun Choi
Keyword(s):  
Pattern Recognition ◽  
Immune System ◽  
Crucial Role ◽  
Innate Immune System ◽  
Innate Immune ◽  
Therapeutic Interventions ◽  
Immune System Diseases ◽  
Target Molecules ◽  
Molecular Patterns ◽  
Recognition Receptor

The immune system plays a crucial role in the body’s defense system against various pathogens, such as bacteria, viruses, and parasites, as well as recognizes non-self- and self-molecules. The innate immune system is composed of special receptors known as pattern recognition receptors, which play a crucial role in the identification of pathogen-associated molecular patterns from diverse microorganisms. Any disequilibrium in the activation of a particular pattern recognition receptor leads to various inflammatory, autoimmune, or immunodeficiency diseases. Aptamers are short single-stranded deoxyribonucleic acid or ribonucleic acid molecules, also termed “chemical antibodies,” which have tremendous specificity and affinity for their target molecules. Their features, such as stability, low immunogenicity, ease of manufacturing, and facile screening against a target, make them preferable as therapeutics. Immune-system–targeting aptamers have a great potential as a targeted therapeutic strategy against immune diseases. This review summarizes components of the innate immune system, aptamer production, pharmacokinetic characteristics of aptamers, and aptamers related to innate-immune-system diseases.

scholarly journals Heterologous Prime-Boost Combinations Highlight the Crucial Role of Adjuvant in Priming the Immune System

2018 ◽  
Vol 9 ◽  
Author(s):  
Annalisa Ciabattini ◽  
Elena Pettini ◽  
Fabio Fiorino ◽  
Simone Lucchesi ◽  
Gabiria Pastore ◽  
...  
Keyword(s):  
Immune System ◽  
Crucial Role

Cellular Adaptive Immune System Plays a Crucial Role in Trastuzumab Clinical Efficacy

2010 ◽  
Vol 28 (21) ◽  
pp. e369-e370 ◽  
Author(s):  
Filippo Bellati ◽  
Chiara Napoletano ◽  
Ilary Ruscito ◽  
Marco Liberati ◽  
Pierluigi Benedetti Panici ◽  
...  
Keyword(s):  
Immune System ◽  
Clinical Efficacy ◽  
Crucial Role ◽  
Adaptive Immune System ◽  
Adaptive Immune

scholarly journals Osteopetrosis: Oral and Maxillofacial Manifestations

2012 ◽  
Vol 3 (2) ◽  
pp. 115-117 ◽  
Author(s):  
Abbas Makarem ◽  
Nosrat Lotfi ◽  
Seyed Amir Danesh-Sani ◽  
Soudabeh Nazifi
Keyword(s):  
Immune System ◽  
Bone Resorption ◽  
Dental Caries ◽  
Early Diagnosis ◽  
Bone Disease ◽  
Crucial Role ◽  
Dental Practitioners ◽  
Life Threatening ◽  
Head Neck

ABSTRACT Osteopetrosis is a rare hereditary bone disease characterized by osteoclasts malfunction and impaired bone resorption. Decreased vascularity of bone as well as compromised immune system may result in oral and maxillofacial complications. Osteomyelitis is life-threatening problem in these patients usually associated with dental caries or abscess. Dental practitioners could play a crucial role in early diagnosis of osteomyelitis and avoid inappropriate treatments and further complications. How to cite this article Makarem A, Lotfi N, Danesh-Sani SA, Nazifi S. Osteopetrosis: Oral and Maxillofacial Manifestations. Int J Head Neck Surg 2012;3(2):115-117.

scholarly journals Studying human immunodeficiencies in humans: advances in fundamental concepts and therapeutic interventions

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 318 ◽  
Author(s):  
Helen Su
Keyword(s):  
Immune System ◽  
Natural Environment ◽  
Crucial Role ◽  
The Body ◽  
Therapeutic Interventions ◽  
Microbial Pathogens ◽  
Gene Products ◽  
Monogenic Diseases

Immunodeficiencies reveal the crucial role of the immune system in defending the body against microbial pathogens. Given advances in genomics and other technologies, this is currently best studied in humans who have inherited monogenic diseases. Such investigations have provided insights into how gene products normally function in the natural environment and have opened the door to new, exciting treatments for these diseases.

Crucial role of innate immune system in the pathogenesis of celiac disease

2016 ◽  
Vol 1 (3) ◽  
pp. 0-0 ◽  
Author(s):  
Haniye Ghasiyari ◽  
Mohammad Rostami Nejad ◽  
Davar Amani ◽  
Davar Amani ◽  
Mohammad Reza Zali ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Immune System ◽  
Crucial Role ◽  
Innate Immune System ◽  
Innate Immune

Studies on phospholipid turnover argue against sloughing of tegumental membranes in adult Schistosoma mansoni

Parasitology ◽  
1999 ◽  
Vol 119 (3) ◽  
pp. 287-294 ◽  
Author(s):  
J. F. H. M. BROUWERS ◽  
P. J. SKELLY ◽  
L. M. G. VAN GOLDE ◽  
A. G. M. TIELENS
Keyword(s):  
Fatty Acid ◽  
Immune System ◽  
Schistosoma Mansoni ◽  
Immune Evasion ◽  
Crucial Role ◽  
Host Immune System ◽  
Pulse Labelling ◽  
High Turnover ◽  
Membrane Complex

The tegumental membrane complex of Schistosoma mansoni is the site of interaction between the parasite and the host. The tegument is involved in uptake of many nutrients, but also plays a crucial role in the evasion of the actions of the host immune system. Essential for the success of this evasion is maintaining the integrity of the tegumental membranes. The rate of turnover of phospholipids was investigated by pulse-labelling worms cultured in vitro, followed by additional incubation in the presence of unlabelled substrates. Tegumental membranes were isolated, characterized using antibodies against specific tegumental proteins, and analysed. It was demonstrated that the most prominent fatty acid found in tegumental phospholipids, palmitate, incorporated rapidly into the phospholipid fraction during a 30 min pulse labelling. In a subsequent 20 h chase with unlabelled substrates, the incorporated radioactivity was lost again from the tegumental membrane complex. This high turnover of palmitate was found to be limited to phosphatidylcholine (PC) only. The turnover was due to deacylation/reacylation, and not to the sloughing of membranes as is the case in schistosomula. It is speculated that this rapid turnover of PC in the tegument of adult schistosomes plays a new and important role in the immune evasion by the parasite.

scholarly journals The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease

2015 ◽  
Vol 43 (4) ◽  
pp. 727-733 ◽  
Author(s):  
John J Worthington
Keyword(s):  
Immune System ◽  
Cross Talk ◽  
Intestinal Epithelium ◽  
Immune Cells ◽  
Inflammatory Disease ◽  
Barrier Function ◽  
Crucial Role ◽  
Enteroendocrine Cells ◽  
Immune Homeostasis

The intestinal epithelium plays a crucial role in maintaining barrier function and immune homeostasis, a failure of which results in disease. This review focuses on the epithelial enteroendocrine cells and the crosstalk that exists with immune cells during inflammation.

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