scholarly journals Transforming Growth Factor-β Is an Upstream Regulator of Mammalian Target of Rapamycin Complex 2–Dependent Bladder Cancer Cell Migration and Invasion

2016 ◽  
Vol 186 (5) ◽  
pp. 1351-1360 ◽  
Author(s):  
Sounak Gupta ◽  
Andrew M. Hau ◽  
Hikmat A. Al-Ahmadie ◽  
Jyoti Harwalkar ◽  
Aaron C. Shoskes ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Migration ◽  
Growth Factor ◽  
Cancer Cell ◽  
Transforming Growth Factor ◽  
Mammalian Target Of Rapamycin ◽  
Transforming Growth Factor Β ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Upstream Regulator

scholarly journals MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA

2008 ◽  
Vol 28 (22) ◽  
pp. 6773-6784 ◽  
Author(s):  
William Kong ◽  
Hua Yang ◽  
Lili He ◽  
Jian-jun Zhao ◽  
Domenico Coppola ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Growth Factor ◽  
Tight Junction ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Migration And Invasion ◽  
Advanced Malignancy ◽  
Mesenchymal Transition ◽  
Cell Migration And Invasion

ABSTRACT Transforming growth factor β (TGF-β) signaling facilitates metastasis in advanced malignancy. While a number of protein-encoding genes are known to be involved in this process, information on the role of microRNAs (miRNAs) in TGF-β-induced cell migration and invasion is still limited. By hybridizing a 515-miRNA oligonucleotide-based microarray library, a total of 28 miRNAs were found to be significantly deregulated in TGF-β-treated normal murine mammary gland (NMuMG) epithelial cells but not Smad4 knockdown NMuMG cells. Among upregulated miRNAs, miR-155 was the most significantly elevated miRNA. TGF-β induces miR-155 expression and promoter activity through Smad4. The knockdown of miR-155 suppressed TGF-β-induced epithelial-mesenchymal transition (EMT) and tight junction dissolution, as well as cell migration and invasion. Further, the ectopic expression of miR-155 reduced RhoA protein and disrupted tight junction formation. Reintroducing RhoA cDNA without the 3′ untranslated region largely reversed the phenotype induced by miR-155 and TGF-β. In addition, elevated levels of miR-155 were frequently detected in invasive breast cancer tissues. These data suggest that miR-155 may play an important role in TGF-β-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention.

scholarly journals miR-451 suppresses bladder cancer cell migration and invasion via directly targeting c-Myc

2016 ◽  
Vol 36 (4) ◽  
pp. 2049-2058 ◽  
Author(s):  
Jun Wang ◽  
Xiaomei Zhao ◽  
Jianhua Shi ◽  
Yiwei Pan ◽  
Qinghai Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion
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