scholarly journals Loss of Lrig1 Leads to Expansion of Brunner Glands Followed by Duodenal Adenomas with Gastric Metaplasia

2015 ◽  
Vol 185 (4) ◽  
pp. 1123-1134 ◽  
Author(s):  
Yang Wang ◽  
Chanjuan Shi ◽  
Yuanyuan Lu ◽  
Emily J. Poulin ◽  
Jeffery L. Franklin ◽  
...  
Keyword(s):  
Duodenal Adenomas ◽  
Gastric Metaplasia ◽  
Brunner Glands

scholarly journals Endoscopic management of superficial nonampullary duodenal tumors: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Endoscopy ◽  
2021 ◽  
Author(s):  
Geoffroy Vanbiervliet ◽  
Alan Moss ◽  
Marianna Arvanitakis ◽  
Urban Arnelo ◽  
Torsten Beyna ◽  
...  
Keyword(s):  
Endoscopic Resection ◽  
En Bloc Resection ◽  
Endoscopic Management ◽  
Duodenal Adenoma ◽  
En Bloc ◽  
Strong Recommendation ◽  
Delayed Bleeding ◽  
Duodenal Adenomas ◽  
Moderate Quality ◽  
Quality Evidence

Main recommendations 1 ESGE recommends that all duodenal adenomas should be considered for endoscopic resection as progression to invasive carcinoma is highly likely.Strong recommendation, low quality evidence. 2 ESGE recommends performance of a colonoscopy, if that has not yet been done, in cases of duodenal adenoma.Strong recommendation, low quality evidence. 3 ESGE recommends the use of the cap-assisted method when the location of the minor and/or major papilla and their relationship to a duodenal adenoma is not clearly established during forward-viewing endoscopy.Strong recommendation, moderate quality evidence. 4 ESGE recommends the routine use of a side-viewing endoscope when a laterally spreading adenoma with extension to the minor and/or major papilla is suspected.Strong recommendation, low quality evidence. 5 ESGE suggests cold snare polypectomy for small (< 6 mm in size) nonmalignant duodenal adenomas.Weak recommendation, low quality evidence. 6 ESGE recommends endoscopic mucosal resection (EMR) as the first-line endoscopic resection technique for nonmalignant large nonampullary duodenal adenomas.Strong recommendation, moderate quality evidence. 7 ESGE recommends that endoscopic submucosal dissection (ESD) for duodenal adenomas is an effective resection technique only in expert hands.Strong recommendation, low quality evidence. 8 ESGE recommends using techniques that minimize adverse events such as immediate or delayed bleeding or perforation. These may include piecemeal resection, defect closure techniques, noncontact hemostasis, and other emerging techniques, and these should be considered on a case-by-case basis.Strong recommendation, low quality evidence. 9 ESGE recommends endoscopic surveillance 3 months after the index treatment. In cases of no recurrence, a further follow-up endoscopy should be done 1 year later. Thereafter, surveillance intervals should be adapted to the lesion site, en bloc resection status, and initial histological result. Strong recommendation, low quality evidence.

scholarly journals Treatment and outcome differences in patients with duodenal adenomas

HPB ◽  
2020 ◽  
Vol 22 ◽  
pp. S73
Author(s):  
N. Handy ◽  
A. Crown ◽  
A. Alseidi ◽  
T. Biehl ◽  
W.S. Helton ◽  
...  
Keyword(s):  
Duodenal Adenomas ◽  
Outcome Differences

Histopathologic Manifestations of Crohn Disease in Duodenal Endoscopy Biopsy: The Value of Different Patterns of Involvement of Brunner Glands

2021 ◽  
pp. 106689692199843
Author(s):  
Badr AbdullGaffar ◽  
Hoda Quraishi
Keyword(s):  
Crohn Disease ◽  
Duodenal Biopsy ◽  
Inflammatory Lesions ◽  
Specific Sign ◽  
Mucosal Erosion ◽  
Transmural Inflammation ◽  
Active Inflammation ◽  
Upper Gastrointestinal ◽  
Brunner Glands ◽  
Duodenal Biopsies

Crohn disease (CD) not uncommonly involves the upper gastrointestinal tract, usually gastric antrum and proximal duodenum. The most consistent histopathologic manifestations of CD in duodenal biopsies are mucosal erosion, focal active inflammation, and granulomas. Since CD is a transmural inflammation and since duodenal biopsy may include submucosal Brunner glands, we aimed to find if CD has any specific histopathologic manifestations in Brunner gland lobules and their ducts compared to other duodenal inflammatory lesions. We carried out a retrospective review study over 6 years retrieving duodenal biopsy specimens in CD patients. We compared duodenal specimens involved by CD with other inflammatory lesions, for example, ulcerative colitis (UC), Helicobacter pylori-associated gastritis, non-Helicobacter gastritis, Celiac sprue, infections, and drugs. We found focal active duodenitis and erosion in CD cases and non-CD cases. Granulomas were found in CD cases. Five cases of CD showed inflammatory and degenerative changes of Brunner glands. Focal patchy active inflammation of only portion of submucosal Brunner gland lobule, mucosal Brunner glands, and their ducts was solely found in CD cases. This focally enhanced inflammation of Brunner glands was not found in other lesions. Whether this phenomenon of focal active “lobulitis” and “ductitis” is a specific sign of duodenal CD compared to UC and other inflammatory lesions warrants verification. We encourage endoscopists to include submucosal Brunner lobules in their duodenal biopsy samples and pathologists to look for these patterns of involvement particularly in patients suspected of CD.

Duodenal Adenomas Coincide with Colorectal Neoplasia

2014 ◽  
Vol 59 (9) ◽  
pp. 2249-2254 ◽  
Author(s):  
Robert M. Genta ◽  
Jennifer M. Hurrell ◽  
Amnon Sonnenberg
Keyword(s):  
Colorectal Neoplasia ◽  
Duodenal Adenomas

scholarly journals Case series of non-ampullary duodenal adenomas

2021 ◽  
Vol 69 ◽  
pp. 102730
Author(s):  
Amitabh Yadav ◽  
Samiran Nundy
Keyword(s):  
Case Series ◽  
Duodenal Adenomas

Endoscopic Management of Duodenal Adenomas in Familial Adenomatous Polyposis—A Single-Center Experience

2011 ◽  
Vol 57 (3) ◽  
pp. 732-737 ◽  
Author(s):  
Sathya Jaganmohan ◽  
Patrick M. Lynch ◽  
Ramu P. Raju ◽  
William A. Ross ◽  
Jeffrey E. Lee ◽  
...  
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Endoscopic Management ◽  
Adenomatous Polyposis ◽  
Single Center ◽  
Duodenal Adenomas ◽  
Single Center Experience
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