scholarly journals Characterization of a New Small Bowel Adenocarcinoma Cell Line and Screening of Anti-Cancer Drug against Small Bowel Adenocarcinoma

2015 ◽  
Vol 185 (2) ◽  
pp. 550-562 ◽  
Author(s):  
Hirobumi Suzuki ◽  
Yoshihiro Hirata ◽  
Nobumi Suzuki ◽  
Sozaburo Ihara ◽  
Kosuke Sakitani ◽  
...  
Keyword(s):  
Small Bowel ◽  
Cell Line ◽  
Cancer Drug ◽  
Small Bowel Adenocarcinoma ◽  
Adenocarcinoma Cell Line ◽  
Adenocarcinoma Cell ◽  
Anti Cancer

Tu1610 Characterization of Small Bowel Adenocarcinoma Cell Line and Evaluation of Anti-Cancer Drug Efficacy Against Small Bowel Adenocarcinoma

2013 ◽  
Vol 144 (5) ◽  
pp. S-805
Author(s):  
Hirobumi Suzuki ◽  
Yoshihiro Hirata ◽  
Souzaburo Ihara ◽  
Kosuke Sakitani ◽  
Yuka Kobayashi ◽  
...  
Keyword(s):  
Small Bowel ◽  
Cell Line ◽  
Drug Efficacy ◽  
Cancer Drug ◽  
Small Bowel Adenocarcinoma ◽  
Adenocarcinoma Cell Line ◽  
Adenocarcinoma Cell ◽  
Anti Cancer

Synthesis, Anti-proliferative Evaluation, and Molecular Docking Studies of 3-(alkylthio)-5,6-diaryl-1,2,4-triazines as Tubulin Polymerization Inhibitors

2019 ◽  
Vol 16 (11) ◽  
pp. 1194-1201 ◽  
Author(s):  
Farhad Saravani ◽  
Ebrahim Saeedian Moghadam ◽  
Hafezeh Salehabadi ◽  
Seyednasser Ostad ◽  
Morteza Pirali Hamedani ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cytotoxic Activity ◽  
Binding Site ◽  
Cell Line ◽  
Cell Lines ◽  
Tubulin Polymerization ◽  
Adenocarcinoma Cell Line ◽  
Adenocarcinoma Cell ◽  
Colchicine Binding Site ◽  
Anti Cancer

Background: The role of microtubules in cell division and signaling, intercellular transport, and mitosis has been well known. Hence, they have been targeted for several anti-cancer drugs. Methods: A series of 3-(alkylthio)-5,6-diphenyl-1,2,4-triazines were prepared and evaluated for their cytotoxic activities in vitro against three human cancer cell lines; human colon carcinoma cells HT-29, human breast adenocarcinoma cell line MCF-7, human Caucasian gastric adenocarcinoma cell line AGS as well as fibroblast cell line NIH-3T3 by MTT assay. Docking simulation was performed to insert these compounds into the crystal structure of tubulin at the colchicine binding site to determine a probable binding model. Compound 5d as the most active compound was selected for studying of microtubule disruption. Results: Compound 5d showed potent cytotoxic activity against all cell lines. The molecular modeling study revealed that some derivatives of triazine strongly bind to colchicine binding site. The tubulin polymerization assay kit showed that the cytotoxic activity of 5d may be related to inhibition of tubulin polymerization. Conclusion: The cytotoxicity and molecular modeling study of the synthesized compounds with their inhibition activity in tubulin polymerization demonstrate the potential of triazine derivatives for development of new anti-cancer agents.

Development and characterization of a mouse prostate adenocarcinoma cell line: Ductal formation determined by extracellular matrix

The Prostate ◽  
1998 ◽  
Vol 34 (1) ◽  
pp. 10-22 ◽  
Author(s):  
Cheryl L. Jorcyk ◽  
Min-Ling Liu ◽  
Masa-Aki Shibata ◽  
Ioanna G. Maroulakou ◽  
Kristin L. Komschlies ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Line ◽  
Prostate Adenocarcinoma ◽  
Adenocarcinoma Cell Line ◽  
Adenocarcinoma Cell ◽  
Mouse Prostate
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