scholarly journals Oxyphil Cell Metaplasia in the Parathyroids Is Characterized by Somatic Mitochondrial DNA Mutations in NADH Dehydrogenase Genes and Cytochrome c Oxidase Activity–Impairing Genes

2014 ◽  
Vol 184 (11) ◽  
pp. 2922-2935 ◽  
Author(s):  
Josef Müller-Höcker ◽  
Sabine Schäfer ◽  
Stefan Krebs ◽  
Helmut Blum ◽  
Gábor Zsurka ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Oxidase Activity ◽  
Nadh Dehydrogenase ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations ◽  
Oxyphil Cell

Mitochondrial DNA replication and transcription are dissociated during embryonic cardiac hypertrophy

1991 ◽  
Vol 261 (6) ◽  
pp. C1091-C1098 ◽  
Author(s):  
J. M. Kennedy ◽  
S. R. Lobacz ◽  
S. W. Kelley
Keyword(s):  
Mitochondrial Dna ◽  
Cytochrome C ◽  
Cardiac Hypertrophy ◽  
Cytochrome C Oxidase ◽  
Oxidase Activity ◽  
Citrate Synthase ◽  
Incubation Temperature ◽  
Mitochondrial Gene ◽  
Gene Replication ◽  
Mitochondrial Dna Copy Number

Cardiac hypertrophy was produced in embryonic chicks by decreasing the incubation temperature from 38 degrees C to 32 degrees C on day 11. Increases in ventricular protein, RNA, and DNA support the cardiac enlargement. Cytochrome-c oxidase activity and citrate synthase activity were depressed in hypothermic ventricles by 63% and 56%, respectively. No significant differences were seen in enzyme activities in pectoralis muscles. The involvement of mitochondrial gene replication and transcription was evaluated using a cDNA clone for the mitochondrially encoded subunit III of cytochrome-c oxidase (CO III). Quantitative slot-blot analysis demonstrated that the relative CO III mRNA concentration was reduced in hypothermic ventricles. In contrast, the relative mitochondrial DNA concentration was increased in hypothermic ventricles. Taken together, these data indicate that a hypothermia-induced decrease in cytochrome-c oxidase activity is associated with a decrease in CO III mRNA, which is not coupled to a decrease in the mitochondrial DNA copy number. This dissociation of mitochondrial gene replication and transcription may provide a useful model for examining the regulation of mitochondrial biogenesis.

scholarly journals Induction and characterization of mitochondrial DNA mutants in Chlamydomonas reinhardtii.

1989 ◽  
Vol 108 (4) ◽  
pp. 1221-1226 ◽  
Author(s):  
R F Matagne ◽  
M R Michel-Wolwertz ◽  
C Munaut ◽  
C Duyckaerts ◽  
F Sluse
Keyword(s):  
Mitochondrial Dna ◽  
Cytochrome C ◽  
Chlamydomonas Reinhardtii ◽  
Cytochrome C Oxidase ◽  
Oxidase Activity ◽  
Wild Type ◽  
Apocytochrome B ◽  
Cytochrome Pathway ◽  
Apocytochrome B Gene

In addition to lethal minute colony mutations which correspond to loss of mitochondrial DNA, acriflavin induces in Chlamydomonas reinhardtii a low percentage of cells that grow in the light but do not divide under heterotrophic conditions. Two such obligate photoautotrophic mutants were shown to lack the cyanide-sensitive cytochrome pathway of the respiration and to have a reduced cytochrome c oxidase activity. In crosses to wild type, the mutations are transmitted almost exclusively from the mating type minus parent. A same pattern of inheritance is seen for the mitochondrial DNA in crosses between the two interfertile species C. reinhardtii and Chlamydomonas smithii. Both mutants have a deletion in the region of the mitochondrial DNA containing the apocytochrome b gene and possibly the unidentified URFx gene.

Decreased Cytochrome-c Oxidase Activity and Lack of Age-Related Accumulation of Mitochondrial DNA Deletions in the Brains of Schizophrenics

Genomics ◽  
1995 ◽  
Vol 29 (1) ◽  
pp. 217-224 ◽  
Author(s):  
Lucia Cavelier ◽  
Elena E. Jazin ◽  
Inger Eriksson ◽  
Jonathan Prince ◽  
Ullvi Båve ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Oxidase Activity ◽  
Age Related ◽  
Dna Deletions

Effect of Chloramphenicol on Enzyme Synthesis and Growth of Mammalian Cells

1972 ◽  
Vol 50 (2) ◽  
pp. 200-209 ◽  
Author(s):  
I. M. Fettes ◽  
D. Haldar ◽  
K. B. Freeman
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Oxidase Activity ◽  
Mammalian Cells ◽  
Nadh Dehydrogenase ◽  
Enzyme Synthesis ◽  
Mitochondrial Proteins ◽  
Mitochondrial Enzymes ◽  
L Cells ◽  
Two Generations

D-threo-Chloramphenicol and its sulfamoyl analogue Tevenel, but not L-chloramphenicol, prevent the formation of a functional cytochrome c oxidase in L cells. The syntheses of several mitochondrial enzymes, malate dehydrogenase, succinate dehydrogenase, NADH dehydrogenase, ATPase, and cytochromes b, c, and c1, were not inhibited. Cycloheximide also inhibited the formation of cytochrome c oxidase. After removal of D-chloramphenicol or Tevenel, cytochrome oxidase activity returned at a rate equivalent to its normal synthesis. L cells continued to grow for up to five generations in the presence of Tevenel at 100 μg/ml but only for 1.5 to two generations with D-chloramphenicol at the same concentration. D-Chloramphenicol specifically inhibited the synthesis of insoluble mitochondrial proteins in ascites cells.

m.6267G>A: a recurrent mutation in the human mitochondrial DNA that reduces cytochrome c oxidase activity and is associated with tumors

2006 ◽  
Vol 27 (6) ◽  
pp. 575-582 ◽  
Author(s):  
M. Esther Gallardo ◽  
Raquel Moreno-Loshuertos ◽  
Celia López ◽  
Mercedes Casqueiro ◽  
Javier Silva ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Oxidase Activity ◽  
Recurrent Mutation ◽  
Human Mitochondrial Dna

scholarly journals Relationship between Mitochondrial DNA Variation and Heterosis in Cytochrome c Oxidase Activity in the Mouse

1991 ◽  
Vol 62 (9) ◽  
pp. 822-828
Author(s):  
Hitoshi MIKAMI ◽  
Akira ONISHI ◽  
Masanori KOMATSU ◽  
Kumiko TAKEDA ◽  
Shigeki INUMARU
Keyword(s):  
Mitochondrial Dna ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Oxidase Activity ◽  
Dna Variation
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