scholarly journals Age-Related Alterations in Regeneration of the Urinary Bladder after Subtotal Cystectomy

2013 ◽  
Vol 183 (5) ◽  
pp. 1585-1595 ◽  
Author(s):  
David M. Burmeister ◽  
Tamer AbouShwareb ◽  
Christopher R. Bergman ◽  
Karl-Erik Andersson ◽  
George J. Christ
Keyword(s):  
Urinary Bladder ◽  
Age Related ◽  
Subtotal Cystectomy

scholarly journals Spontaneous and Drug-induced Arteritis/Polyarteritis in the Göttingen Minipig—Review

2018 ◽  
Vol 46 (2) ◽  
pp. 121-130 ◽  
Author(s):  
Zuhal Dincer ◽  
Virginie Piccicuto ◽  
Ursula Junker Walker ◽  
Andreas Mahl ◽  
Sean McKeag
Keyword(s):  
Spinal Cord ◽  
Urinary Bladder ◽  
Blood Vessels ◽  
Polyarteritis Nodosa ◽  
Pain Syndrome ◽  
Vascular Changes ◽  
Drug Induced ◽  
Göttingen Minipig ◽  
Age Related ◽  
Immune Mediated

Arteritis/polyarteritis occurs spontaneously in many species used in preclinical toxicology studies. In Göttingen minipigs, arteritis/polyarteritis is an occasionally observed background change. In the minipig, this finding differs in frequency and nature from age-related polyarteritis nodosa in rats or monkeys, and Beagle pain syndrome in dogs. In minipigs, it can be present in a single small- or medium-sized artery of an organ or a few organs and is most commonly recorded in the cardiac and extracardiac blood vessels, vagina, oviduct, rectum, epididymis, spinal cord, pancreas, urinary bladder, kidneys, and stomach. The etiology is unknown although it has been considered in minipigs as well as in rats, dogs, and monkeys to be possibly immune mediated. This background change is important with respect to its nature and distribution in the minipig in order to distinguish it from drug-induced vascular changes, which might occur in similar locations and have similar morphologic features. This review summarizes the morphology, incidence, and predilection sites of arteritis as a spontaneously occurring background change and as a drug-induced vasculopathy in the minipig, and also describes the main aspects to consider when evaluating vascular changes in Göttingen minipig toxicity studies and their human relevance.

Age‐related changes in urinary bladder intramural neurons

2007 ◽  
Vol 25 (3) ◽  
pp. 141-148 ◽  
Author(s):  
Marcia Sanae Mizuno ◽  
Eduardo Pompeu ◽  
Patricia Castelucci ◽  
Edson Aparecido Liberti
Keyword(s):  
Urinary Bladder ◽  
Age Related ◽  
Age Related Changes

Aging impairs neurogenic contraction in guinea pig urinary bladder: role of oxidative stress and melatonin

2007 ◽  
Vol 293 (2) ◽  
pp. R793-R803 ◽  
Author(s):  
Pedro J. Gómez-Pinilla ◽  
Maria J. Pozo ◽  
Pedro J. Camello
Keyword(s):  
Oxidative Stress ◽  
Urinary Bladder ◽  
Guinea Pig ◽  
Electrical Field Stimulation ◽  
Neuromuscular Function ◽  
Melatonin Treatment ◽  
Age Related ◽  
Afferent Fibers ◽  
Bladder Disorders ◽  
The Impact

The incidence of urinary bladder disturbances increases with age, and free radical accumulation has been proposed as a causal factor. Here we investigated the association between changes in bladder neuromuscular function and oxidative stress in aging and the possible benefits of melatonin treatment. Neuromuscular function was assessed by electrical field stimulation (EFS) of isolated guinea pig detrusor strips from adult and aged female guinea pigs. A group of adult and aged animals were treated with 2.5 mg·kg−1·day−1 melatonin for 28 days. Neurotransmitter blockers were used to dissect pharmacologically the EFS-elicited contractile response. EFS induced a neurogenic and frequency-dependent contraction that was impaired by aging. This impairment is in part related to a decrease in detrusor myogenic contractility. Age also decreased the sensitivity of the contraction to pharmacological blockade of purinergic and sensitive fibers but increased the effect of blockade of nitrergic and adrenergic nerves. The density of cholinergic and nitrergic nerves remained unaltered, but aging modified afferent fibers. These changes were associated with an increased level of markers for oxidative stress. Melatonin treatment normalized oxidative levels and counteracted the aging-associated changes in bladder neuromuscular function. In conclusion, these results show that aging modifies neurogenic contraction and the functional profile of the urinary bladder plexus and simultaneously increases the oxidative damage to the organ. Melatonin reduces oxidative stress and improves the age-induced changes in bladder neuromuscular function, which could be of importance in reducing the impact of age-related bladder disorders.

Age-related changes in sensitivity of rat urinary bladder to atonomic agents

1984 ◽  
Vol 27 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Malak G. Kolta ◽  
Lane J. Wallace ◽  
Michael C. Gerald
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder ◽  
Age Related ◽  
Age Related Changes

Age-related changes in the response of the rat urinary bladder to neurotransmitters

1993 ◽  
Vol 12 (2) ◽  
pp. 191-200 ◽  
Author(s):  
Masahiko Saito ◽  
Atsuo Kondo ◽  
Momokazu Gotoh ◽  
Kumiko Kato ◽  
Robert M. Levin
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder ◽  
Age Related ◽  
Age Related Changes

Age-related change in α-adrenergic responsiveness of the urinary bladder of the rat is regionally specific

1986 ◽  
Vol 25 (12) ◽  
pp. 1335-1340 ◽  
Author(s):  
G.A. Ordway ◽  
M.G. Kolta ◽  
M.C. Gerald ◽  
L.J. Wallace
Keyword(s):  
Urinary Bladder ◽  
Age Related
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