scholarly journals Short-Term Akt Activation in Cardiac Muscle Cells Improves Contractile Function in Failing Hearts

2012 ◽  
Vol 181 (6) ◽  
pp. 1969-1976 ◽  
Author(s):  
Ichiro Shiojima ◽  
Stephan Schiekofer ◽  
Jochen G. Schneider ◽  
Kurt Belisle ◽  
Kaori Sato ◽  
...  
Keyword(s):  
Cardiac Muscle ◽  
Contractile Function ◽  
Muscle Cells ◽  
Short Term ◽  
Cardiac Muscle Cells ◽  
Akt Activation

Cardiocyte contractile performance in experimental biventricular volume-overload hypertrophy

1993 ◽  
Vol 264 (5) ◽  
pp. H1615-H1623 ◽  
Author(s):  
Y. Urabe ◽  
Y. Hamada ◽  
F. G. Spinale ◽  
B. A. Carabello ◽  
R. L. Kent ◽  
...  
Keyword(s):  
Cardiac Muscle ◽  
Contractile Function ◽  
Volume Overload ◽  
Fold Increase ◽  
Muscle Cells ◽  
Diffraction Measurement ◽  
Cardiac Muscle Cells ◽  
Significant Difference ◽  
Feline Model ◽  
Contractile Performance

Previous studies have shown that the right ventricle (RV) appears to tolerate volume overloading better than does the left ventricle (LV). To determine whether this dichotomous response is due to intrinsic differences in the contractile performance of volume hypertrophied RV vs. LV cardiac muscle cells, or cardiocytes, we characterized the contractile performance of cardiocytes isolated from an experimental feline model of biventricular volume overload (n = 7 cats), wherein a peripheral arteriovenous fistula (AVF) produced an identical duration and degree of volume overload for both ventricles; sham-operated cats served as the appropriate controls (n = 7). Cardiocyte contractile function was defined by laser diffraction measurement of sarcomere motion. For the AVF cats, there was a 2.4-fold increase in cardiac output, a significant increase in the RV and LV weight-to-body weight ratios, and a significant increase in cell surface area for the RV and LV cardiocytes. Despite this, cardiocyte contractile function in the AVF cats was entirely normal. Thus there was no significant difference between RV and LV cardiocytes from control cats in the extent or velocity of sarcomere shortening either in 1 cP superfusate or in higher viscosity superfusates, and comparison of RV and LV cells from the AVF cats to those from sham-operated cats again revealed no significant differences. Furthermore, cardiocyte relengthening properties showed no significant differences between AVF and control groups. In summary, this study shows that contractile dysfunction is not an inherent property of either RV or LV cardiac muscle cells hypertrophying in response to substantial volume overloading when preload is increased but afterload is normal.

THE EFFECTS OF ACUPUNCTURE ON CARDIAC MUSCLE CELLS AND BLOOD PRESSURE IN SPONTANEOUS HYPERTENSIVE RATS

2004 ◽  
Vol 29 (1) ◽  
pp. 83-95 ◽  
Author(s):  
Hung-Chien Wu ◽  
Jaung-Geng Lin ◽  
Chun-Hsien Chu ◽  
Yung-Hsien Chang ◽  
Chung-Gwo Chang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiac Muscle ◽  
Muscle Cells ◽  
Hypertensive Rats ◽  
Cardiac Muscle Cells

Dendroaspis Natriuretic Peptide Induces the Apoptosis of Cardiac Muscle Cells

2005 ◽  
Vol 27 (1) ◽  
pp. 33-51 ◽  
Author(s):  
Ki-Chan Ha ◽  
Han-Jung Chae ◽  
Cheng-Shi Piao ◽  
Suhn-Hee Kim ◽  
Hyung-Ryong Kim ◽  
...  
Keyword(s):  
Cardiac Muscle ◽  
Natriuretic Peptide ◽  
Muscle Cells ◽  
Cardiac Muscle Cells

Microwave Radiation Effects on Cardiac Muscle Cells in Vitro

1981 ◽  
Vol 86 (2) ◽  
pp. 358 ◽  
Author(s):  
M. J. Galvin ◽  
C. A. Hall ◽  
D. I. McRee
Keyword(s):  
Cardiac Muscle ◽  
Microwave Radiation ◽  
Radiation Effects ◽  
Muscle Cells ◽  
Cardiac Muscle Cells

Contractile behaviors of cardiac muscle cells on mushroom-shaped micropillar arrays

2019 ◽  
Vol 174 ◽  
pp. 103-109 ◽  
Author(s):  
Nomin-Erdene Oyunbaatar ◽  
Arunkumar Shanmugasundaram ◽  
Dong-Weon Lee
Keyword(s):  
Cardiac Muscle ◽  
Muscle Cells ◽  
Cardiac Muscle Cells ◽  
Micropillar Arrays
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