scholarly journals Lactobacillus rhamnosus GG Treatment Potentiates Intestinal Hypoxia-Inducible Factor, Promotes Intestinal Integrity and Ameliorates Alcohol-Induced Liver Injury

2011 ◽  
Vol 179 (6) ◽  
pp. 2866-2875 ◽  
Author(s):  
Yuhua Wang ◽  
Irina Kirpich ◽  
Yanlong Liu ◽  
Zhenhua Ma ◽  
Shirish Barve ◽  
...  
Keyword(s):  
Liver Injury ◽  
Hypoxia Inducible Factor ◽  
Lactobacillus Rhamnosus ◽  
Lactobacillus Rhamnosus Gg ◽  
Intestinal Integrity ◽  
Intestinal Hypoxia

scholarly journals Regulation of oxidative liver injury by the probiotic Lactobacillus rhamnosus GG

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Bejan Jon Saeedi ◽  
Brian Robinson ◽  
Joshua Owens ◽  
Ken Liu ◽  
Liping Luo ◽  
...  
Keyword(s):  
Liver Injury ◽  
Lactobacillus Rhamnosus ◽  
Lactobacillus Rhamnosus Gg ◽  
Probiotic Lactobacillus

Lactobacillus rhamnosus GG Ameliorates Liver Injury and Hypoxic Hepatitis in Rat Model of CLP-Induced Sepsis

2019 ◽  
Vol 64 (10) ◽  
pp. 2867-2877 ◽  
Author(s):  
Lei Ding ◽  
Yihang Gong ◽  
Zhengfei Yang ◽  
Baojia Zou ◽  
Xialei Liu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Rat Model ◽  
Lactobacillus Rhamnosus ◽  
Lactobacillus Rhamnosus Gg ◽  
Hypoxic Hepatitis

scholarly journals Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury

2012 ◽  
Vol 303 (1) ◽  
pp. G32-G41 ◽  
Author(s):  
Yuhua Wang ◽  
Yanlong Liu ◽  
Anju Sidhu ◽  
Zhenhua Ma ◽  
Craig McClain ◽  
...  
Keyword(s):  
Liver Injury ◽  
Intestinal Permeability ◽  
Culture Supernatant ◽  
Ex Vivo ◽  
Liver Steatosis ◽  
Lactobacillus Rhamnosus ◽  
Intestinal Barrier ◽  
Chow Diet ◽  
Mrna Levels ◽  
Lactobacillus Rhamnosus Gg

Endotoxemia is a contributing cofactor to alcoholic liver disease (ALD), and alcohol-induced increased intestinal permeability is one of the mechanisms of endotoxin absorption. Probiotic bacteria have been shown to promote intestinal epithelial integrity and protect barrier function in inflammatory bowel disease (IBD) and in ALD. Although it is highly possible that some common molecules secreted by probiotics contribute to this action in IBD, the effect of probiotic culture supernatant has not yet been studied in ALD. We examined the effects of Lactobacillus rhamnosus GG culture supernatant (LGG-s) on the acute alcohol-induced intestinal integrity and liver injury in a mouse model. Mice on standard chow diet were supplemented with supernatant from LGG culture (109 colony-forming unit/mouse) for 5 days, and one dose of alcohol at 6 g/kg body wt was administered via gavage. Intestinal permeability was measured by FITC-FD-4 ex vivo. Alcohol-induced liver injury was examined by measuring the activity of alanine aminotransferase (ALT) in plasma, and liver steatosis was evaluated by triglyceride content and Oil Red O staining of the liver sections. LGG-s pretreatment restored alcohol-induced reduction in ileum mRNA levels of claudin-1, intestine trefoil factor (ITF), P-glycoprotein (P-gp), and cathelin-related antimicrobial peptide (CRAMP), which play important roles on intestinal barrier integrity. As a result, LGG-s pretreatment significantly inhibited the alcohol-induced intestinal permeability, endotoxemia and subsequently liver injury. Interestingly, LGG-s pretreatment increased ileum mRNA expression of hypoxia-inducible factor (HIF)-2α, an important transcription factor of ITF, P-gp, and CRAMP. These results suggest that LGG-s ameliorates the acute alcohol-induced liver injury by promoting HIF signaling, leading to the suppression of alcohol-induced increased intestinal permeability and endotoxemia. The use of bacteria-free LGG culture supernatant provides a novel strategy for prevention of acute alcohol-induced liver injury.

scholarly journals Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury

2013 ◽  
Vol 24 (9) ◽  
pp. 1609-1615 ◽  
Author(s):  
Yuhua Wang ◽  
Yanlong Liu ◽  
Irina Kirpich ◽  
Zhenhua Ma ◽  
Cuiling Wang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Lactobacillus Rhamnosus ◽  
Chronic Alcohol ◽  
Lactobacillus Rhamnosus Gg
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