scholarly journals Bmp6 Regulates Retinal Iron Homeostasis and Has Altered Expression in Age-Related Macular Degeneration

2011 ◽  
Vol 179 (1) ◽  
pp. 335-348 ◽  
Author(s):  
Majda Hadziahmetovic ◽  
Ying Song ◽  
Natalie Wolkow ◽  
Jared Iacovelli ◽  
Leon Kautz ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Iron Homeostasis ◽  
Age Related Macular Degeneration ◽  
Altered Expression ◽  
Age Related

scholarly journals Oxidative and Nitrosative Stress in Age-Related Macular Degeneration: A Review of Their Role in Different Stages of Disease

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 653
Author(s):  
Caterina Toma ◽  
Stefano De Cillà ◽  
Aurelio Palumbo ◽  
Divya Praveen Garhwal ◽  
Elena Grossini
Keyword(s):  
Macular Degeneration ◽  
Nitrosative Stress ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Choroidal Blood Flow ◽  
Oxidative And Nitrosative Stress ◽  
In Vivo Models ◽  
Altered Expression ◽  
Age Related

Although the exact pathogenetic mechanisms leading to age-related macular degeneration (AMD) have not been clearly identified, oxidative damage in the retina and choroid due to an imbalance between local oxidants/anti-oxidant systems leading to chronic inflammation could represent the trigger event. Different in vitro and in vivo models have demonstrated the involvement of reactive oxygen species generated in a highly oxidative environment in the development of drusen and retinal pigment epithelium (RPE) changes in the initial pathologic processes of AMD; moreover, recent evidence has highlighted the possible association of oxidative stress and neovascular AMD. Nitric oxide (NO), which is known to play a key role in retinal physiological processes and in the regulation of choroidal blood flow, under pathologic conditions could lead to RPE/photoreceptor degeneration due to the generation of peroxynitrite, a potentially cytotoxic tyrosine-nitrating molecule. Furthermore, the altered expression of the different isoforms of NO synthases could be involved in choroidal microvascular changes leading to neovascularization. The purpose of this review was to investigate the different pathways activated by oxidative/nitrosative stress in the pathogenesis of AMD, focusing on the mechanisms leading to neovascularization and on the possible protective role of anti-vascular endothelial growth factor agents in this context.

Altered Expression of CD46 and CD59 on Leukocytes in Neovascular Age-Related Macular Degeneration

2012 ◽  
Vol 154 (1) ◽  
pp. 193-199.e2 ◽  
Author(s):  
Amardeep Singh ◽  
Carsten Faber ◽  
Mads Falk ◽  
Mogens H. Nissen ◽  
Thomas V.F. Hviid ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Altered Expression ◽  
Age Related

scholarly journals A widespread decrease of chromatin accessibility in age-related macular degeneration

2018 ◽  
Author(s):  
Jie Wang ◽  
Cristina Zibetti ◽  
Peng Shang ◽  
Srinivasa R. Sripathi ◽  
Pingwu Zhang ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Advanced Disease ◽  
The Elderly ◽  
Chromatin Accessibility ◽  
Age Related Macular Degeneration ◽  
Epigenetic Changes ◽  
Altered Expression ◽  
Rpe Cells ◽  
Age Related ◽  
Pigmented Epithelium

AbstractAge-related macular degeneration (AMD) is a leading cause of blindness in the elderly. The extent to which epigenetic changes regulate AMD progression is unclear. Here we globally profiled chromatin accessibility in the retina and retinal pigmented epithelium (RPE) from AMD patients and controls. Global decreases in chromatin accessibility occurr in RPE in early AMD, and in the retina with advanced disease, suggesting that dysfunction in RPE cells drives disease progression. Footprints of photoreceptor and RPE-specific transcription factors are enriched in differentially accessible regions (DARs). Genes associated with DARs show altered expression in AMD. Cigarette smoke treatment of RPE cells recapitulates epigenomic changes seen in AMD, providing an epigenetic link between the known risk factors for AMD and AMD pathology. Finally, overexpression of HDAC11 is partially responsible for the reduction in chromatin accessibility, identifying potential new targets for treatment of AMD.

Age related macular degeneration (ARMD) – pathophysiological and clinical features and therapeutic concepts

2001 ◽  
Vol 58 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Ursula Körner-Stiefbold
Keyword(s):  
Macular Degeneration ◽  
Clinical Features ◽  
Altersbedingte Makuladegeneration ◽  
Age Related Macular Degeneration ◽  
Genetische Faktoren ◽  
Age Related ◽  
Therapeutic Concepts

Die altersbedingte Makuladegeneration (AMD) ist eine der häufigsten Ursachen für einen irreversiblen Visusverlust bei Patienten über 65 Jahre. Nahezu 30% der über 75-Jährigen sind von einer AMD betroffen. Trotz neuer Erkenntnisse in der Grundlagenforschung ist die Ätiologie, zu der auch genetische Faktoren gehören, noch nicht völlig geklärt. Aus diesem Grund sind die Behandlungsmöglichkeiten zum jetzigen Zeitpunkt noch limitiert, so dass man lediglich von Therapieansätzen sprechen kann. Die derzeit zur Verfügung stehenden Möglichkeiten wie medikamentöse, chirurgische und laser- und strahlentherapeutische Maßnahmen werden beschrieben.

Nutrition in Age-Related Macular Degeneration Survey

2018 ◽  
Author(s):  
Rebekah Stevens ◽  
Richard Cooke ◽  
Hannah Bartlett
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related
Sign in / Sign up

Export Citation Format

Share Document