23: The impact of life-long maternal HIV infection on pregnancy outcomes in women delivering in south carolina

2016 ◽  
Vol 215 (6) ◽  
pp. S825
Author(s):  
A.M. Powell ◽  
S. Sullivan ◽  
D.E. Soper ◽  
G.B. Lazenby
Keyword(s):  
South Carolina ◽  
Hiv Infection ◽  
Pregnancy Outcomes ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
The Impact

The impact of maternal HIV infection on parenting in inner-city African American families.

1997 ◽  
Vol 11 (4) ◽  
pp. 447-461 ◽  
Author(s):  
Beth A. Kotchick ◽  
Rex Forehand ◽  
Gene Brody ◽  
Lisa Armistead ◽  
Patricia Simon ◽  
...  
Keyword(s):  
African American ◽  
Hiv Infection ◽  
Inner City ◽  
African American Families ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
The Impact ◽  
American Families

scholarly journals Impact of maternal HIV infection on pregnancy outcomes in southwestern China – a hospital registry based study

2019 ◽  
Vol 147 ◽  
Author(s):  
M. Yang ◽  
Y. Wang ◽  
Y. Chen ◽  
Y. Zhou ◽  
Q. Jiang
Keyword(s):  
Immune Deficiency ◽  
Hiv Infection ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Southwestern China ◽  
Hiv Positive ◽  
Rural Residence ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Adverse Pregnancy

AbstractGlobally, human immune deficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) continues to be a major public health issue. With improved survival, the number of people living with HIV/AIDS is increasing, with over 2 million among pregnant women. Investigating adverse pregnant outcomes of HIV-infected population and associated factors are of great importance to maternal and infant health. A cross-sectional data collected from hospital delivery records of 4397 mother–infant pairs in southwestern China were analysed. Adverse pregnant outcomes (including low birthweight/preterm delivery/low Apgar score) and maternal HIV status and other characteristics were measured. Two hundred thirteen (4.9%) mothers were HIV positive; maternal HIV infection, rural residence and pregnancy history were associated with all three indicators of adverse pregnancy outcomes. This research suggested that maternal population have high prevalence in HIV infection in this region. HIV-infected women had higher risks of experiencing adverse pregnancy outcomes. Rural residence predisposes adverse pregnancy outcomes. Findings of this study suggest social and medical support for maternal-infant care needed in this region, selectively towards rural areas and HIV-positive mothers.

scholarly journals Maternal HIV infection and risk of adverse pregnancy outcomes in Hunan province, China

Medicine ◽  
2020 ◽  
Vol 99 (8) ◽  
pp. e19213
Author(s):  
Huixia Li ◽  
Jiahui Liu ◽  
Danfeng Tan ◽  
Guangwen Huang ◽  
Jianfei Zheng ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Hunan Province ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Adverse Pregnancy

scholarly journals Assessing the Effects of Maternal HIV Infection on Pregnancy Outcomes using Cross-sectional Data in Malawi

2020 ◽  
Author(s):  
Halima Sumayya Twabi ◽  
Samuel O Manda ◽  
Dylan S Small
Keyword(s):  
Birth Weight ◽  
Hiv Infection ◽  
Perinatal Mortality ◽  
Pregnancy Outcomes ◽  
Demographic And Health Surveys ◽  
Cross Sectional ◽  
Hiv Test ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Adverse Pregnancy

Abstract Background : Several studies have shown that maternal HIV infection is associated with adverse pregnancy outcomes such as low birth weight and perinatal mortality. However, the association is conflicted with the effect of antiretroviral therapy (ART) on the pregnancy outcomes and it remains unexamined. Using methods for matching possible confounders, the objectives of the study were to assess the effect of maternal HIV on birth weight and perinatal mortality and to investigate the effect of ART on these two pregnancy outcomes in HIV-infected women. Methods: Data on 4111 and 4759 children, born within five years of the 2010 and 2015-16 Malawi Demographic and Health Surveys (MDHS) respectively, whose mothers had an HIV test result, were analysed. A best balancing method was chosen from a set of covariate balance methods namely, the 1:1 nearest neighbour (NN) matching, matching on the propensity score (PS) and inverse weighting on the PS. HIV and ART data were only available in the MDHS 2010, permitting an assessment of the moderating effect of ART on the association between maternal HIV infection and birth weight and perinatal mortality. Results: In 2010, maternal HIV infection was negatively associated with birth weight (-25.3g, 95% CI:(-95.5, -7.4)) and in 2015-16 it was positively associated with birth weight (116.3g, 95 % CI:(27.8, 204.7)). Perinatal mortality was higher in infants of HIV-infected mothers compared to infants of HIV-uninfected mothers (OR = 1.5, 95% CI:(1.1 - 3.1)) in 2010, while there was no difference in the rate in 2015-16 (OR = 1.0, 95% CI:(0.4, 1.6)). ART was not associated with birth weight, however, it was associated with perinatal mortality (OR=3.9, 95% CI:(1.1, 14.8)). Conclusion: The study has found that maternal HIV infection had an adverse effect on birth weight and perinatal mortality in 2010. Birth weight was not dependent on ART uptake but perinatal mortality was higher among infants of HIV-infected mothers who were not on ART. The higher birth weight among HIV-infected mothers and similarity in perinatal mortality with HIV-uninfected mothers in 2015-16 may be indicative of successes of interventions within the PMTCT program in Malawi.

scholarly journals Impact of Maternal HIV Infection and Placental Malaria on the Transplacental Transfer of Influenza Antibodies in Mother–Infant Pairs in Malawi, 2013–2014

2019 ◽  
Vol 6 (10) ◽  
Author(s):  
Antonia Ho ◽  
Gugulethu Mapurisa ◽  
Mwayiwawo Madanitsa ◽  
Linda Kalilani-Phiri ◽  
Steve Kamiza ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hiv Infection ◽  
Malaria Transmission ◽  
Influenza A ◽  
Placental Malaria ◽  
Transplacental Transfer ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Antibody Levels ◽  
The Impact

Abstract Background Maternal influenza vaccination protects infants against influenza virus infection. Impaired transplacental transfer of influenza antibodies may reduce this protection. Methods We conducted a cross-sectional study of influenza vaccine–naïve pregnant women recruited at delivery from Blantyre (urban, low malaria transmission) and Chikwawa (rural, high malaria transmission) in Southern Malawi. HIV-infected mothers were excluded in Chikwawa. Maternal and cord blood antibodies against circulating influenza strains A/California/7/2009, A/Victoria/361/2011, B/Brisbane/60/2008, and B/Wisconsin/1/2010 were measured by hemagglutination inhibition (HAI). We studied the impact of maternal HIV infection and placental malaria on influenza antibody levels in mother–infant pairs in Blantyre and Chikwawa, respectively. Results We included 454 mother–infant pairs (Blantyre, n = 253; Chikwawa, n = 201). HIV-infected mothers and their infants had lower seropositivity (HAI titer ≥1:40) against influenza A(H1N1)pdm09 (mothers, 24.3 vs 45.4%; P = .02; infants, 24.3 vs 50.5%; P = .003) and A(H3N2) (mothers, 37.8% vs 63.9%; P = .003; infants, 43.2 vs 64.8%; P = .01), whereas placental malaria had an inconsistent effect on maternal and infant seropositivity. In multivariable analyses, maternal HIV infection was associated with reduced infant seropositivity (A(H1N1)pdm09: adjusted odds ratio [aOR], 0.34; 95% confidence interval [CI], 0.15–0.79; A(H3N2): aOR, 0.43; 95% CI, 0.21–0.89). Transplacental transfer was not impaired by maternal HIV or placental malaria. Conclusions Maternal HIV infection influenced maternal antibody response to influenza A virus infection, and thereby antibody levels in newborns, but did not affect transplacental antibody transfer.

RISK FOR PERINATAL HIV-1 TRANSMISSION ACCORDING TO MATERNAL IMMUNOLOGIC, VIROLOGIC, AND PLACENTAL FACTORS

PEDIATRICS ◽  
1994 ◽  
Vol 94 (2) ◽  
pp. 275-276
Author(s):  
Joseph Church
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Hiv Transmission ◽  
Perinatal Hiv ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
The Impact ◽  
Hiv 1

Subgroups of HIV-infected women based upon maternal immunologic and placental characteristics had a risk of perinatal HIV transmission that varied from 7% to 71%. The impact of different risk factors for perinatal HIV vary over the course of maternal HIV infection.

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