Is comprehensive surgical staging needed for thorough evaluation of early stage ovarian carcinoma? (Journal Club article for discussion March 2012 re: W11-0302)

2012 ◽  
Author(s):  
Linda Van Le ◽  
George A. Macones
Keyword(s):  
Ovarian Carcinoma ◽  
Early Stage ◽  
Journal Club ◽  
Surgical Staging

scholarly journals The attributive value of comprehensive surgical staging in clinically early-stage epithelial ovarian carcinoma: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Renée E.W.M. van de Vorst ◽  
Jacob P. Hoogendam ◽  
Maaike A. van der Aa ◽  
Petronella O. Witteveen ◽  
Ronald P. Zweemer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ovarian Carcinoma ◽  
Early Stage ◽  
Meta Analysis ◽  
Epithelial Ovarian Carcinoma ◽  
Surgical Staging

scholarly journals The attributive value of comprehensive surgical staging in clinically early-stage epithelial ovarian carcinoma: a systematic review and meta-analysis.

2020 ◽  
Author(s):  
Renée van de Vorst ◽  
Jacob Hoogendam ◽  
Maaike van der Aa ◽  
Petronella Oda Witteveen ◽  
Ronald Zweemer ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Early Stage ◽  
Meta Analysis ◽  
Clinical Stage ◽  
Lymph Node Involvement ◽  
Epithelial Ovarian Carcinoma ◽  
Surgical Staging ◽  
Cochrane Library ◽  
High Grade ◽  
Newcastle Ottawa Scale

Background: Tumor positivity and upstaging rates from various surgical staging components performed in clinically early-stage epithelial ovarian carcinoma (EOC) vary widely in literature. Objectives: To quantify tumor positivity and upstaging rates for all staging surgery components in EOC patients. Differences between subgroups based on their clinical and histological characteristics are explored. Search strategy: A systematic search using synonyms of ‘ovarian cancer’, ‘neoplasm staging’, and ’neoplasm metastasis’ was conducted in PubMed, Embase, and the Cochrane Library. Selection criteria: Meta-analysis was performed on 23 included studies, comprising 5194 clinical stage I or II EOC patients who underwent comprehensive surgical staging. Data Collection and Analysis: Studies were assessed using the Newcastle-Ottawa Scale risk-of-bias tool. Pooled proportions and 95% confidence intervals were calculated using an inverse variance weighted random-effects model. Main Results: Overall upstaging rate of clinically early-stage EOC patients was 18.7% (95%CI: 14.1-23.4%). Serous histology or high grade EOC showed the highest upstaging rate at 35.3% (95%CI: 21.8-48.7%) and 40.9% (95%CI: 35.6-46.2%). Lymph node involvement resulted in an upstaging rate of 8.7% (95%CI: 6.2-11.3%). Tumor was identified in uterus, cytology, peritoneal biopsies, omentum and appendix in 6.2% (95%CI: 1.8-10.7%), 18.4% (95%CI: 13.8-22.9%), 9.7% (95%CI: 3.8-15.6%), 5.2% (95%CI: 1.7-8.8%) and 3.6% (95%CI: 0.0-7.5%) of EOC patients. The corresponding upstaging rates were 5.9% (95%CI: 1.4-10.4%), 8.5% (95%CI: 1.8-15.2%), 3.5% (95%CI: 1.0-6.0%), 3.9% (95%CI: 1.4-6.3%) and 1.6% (95%CI: 0.0-3.4%), respectively. Conclusion: The attributive value of comprehensive surgical staging in clinically early-stage EOC patients remains substantial, particularly in serous and high grade tumors.

The value of surgical staging in patients with apparent early stage epithelial ovarian carcinoma

2019 ◽  
Vol 154 (2) ◽  
pp. 308-313 ◽  
Author(s):  
E.M. Hengeveld ◽  
P.L.M. Zusterzeel ◽  
H. Lajer ◽  
C.K. Høgdall ◽  
M. Rosendahl
Keyword(s):  
Ovarian Carcinoma ◽  
Early Stage ◽  
Epithelial Ovarian Carcinoma ◽  
Surgical Staging

The Benefits of Comprehensive Surgical Staging in the Management of Early-Stage Epithelial Ovarian Carcinoma

2002 ◽  
Vol 85 (2) ◽  
pp. 351-355 ◽  
Author(s):  
Tien Le ◽  
Allyson Adolph ◽  
G.V. Krepart ◽  
R. Lotocki ◽  
M.S. Heywood
Keyword(s):  
Ovarian Carcinoma ◽  
Early Stage ◽  
Epithelial Ovarian Carcinoma ◽  
Surgical Staging

Is comprehensive surgical staging needed for thorough evaluation of early-stage ovarian carcinoma?

2012 ◽  
Vol 206 (3) ◽  
pp. 242.e1-242.e5 ◽  
Author(s):  
Arlene E. Garcia-Soto ◽  
Todd Boren ◽  
Shana N. Wingo ◽  
Thomas Heffernen ◽  
David S. Miller
Keyword(s):  
Ovarian Carcinoma ◽  
Early Stage ◽  
Surgical Staging

Minimally Invasive Surgical Staging in Early-stage Ovarian Carcinoma: A Systematic Review and Meta-analysis

2017 ◽  
Vol 24 (4) ◽  
pp. 552-562 ◽  
Author(s):  
Giorgio Bogani ◽  
Chiara Borghi ◽  
Umberto Leone Roberti Maggiore ◽  
Antonino Ditto ◽  
Mauro Signorelli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Minimally Invasive ◽  
Ovarian Carcinoma ◽  
Early Stage ◽  
Meta Analysis ◽  
Surgical Staging ◽  
Minimally Invasive Surgical
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