Direct cost comparison of group B streptococcus prophylaxis regimens in patients with penicillin allergy

2006 ◽  
Vol 195 (6) ◽  
pp. S52
Author(s):  
Clayton Fitzpatrick ◽  
Leo Brancazio ◽  
Terrence Allen ◽  
Geeta Swamy ◽  
Phillip Heine
Keyword(s):  
Direct Cost ◽  
Group B Streptococcus ◽  
Penicillin Allergy ◽  
Cost Comparison ◽  
Group B

scholarly journals Group B Streptococcus prophylaxis in patients who report a penicillin allergy: a follow-up study

2011 ◽  
Vol 204 (2) ◽  
pp. 150.e1-150.e8 ◽  
Author(s):  
Agatha S. Critchfield ◽  
Stacey P. Lievense ◽  
Christina A. Raker ◽  
Kristen A. Matteson
Keyword(s):  
Group B Streptococcus ◽  
Penicillin Allergy ◽  
Follow Up Study ◽  
Group B

scholarly journals 142. Impact of an Antimicrobial Stewardship Intervention on Antibiotic Prescribing in Patients with Obstetric Infection and Penicillin Allergy

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S86-S86
Author(s):  
Katelyn Quartuccio ◽  
Kelly Golden ◽  
Brenda L Tesini ◽  
Eric Heintz ◽  
Neil Seligman ◽  
...  
Keyword(s):  
Positive Impact ◽  
Group B Streptococcus ◽  
Intervention Group ◽  
Penicillin Allergy ◽  
Antibiotic Prescribing ◽  
Beta Lactam ◽  
Post Intervention ◽  
Early Onset Sepsis ◽  
Group B ◽  
The Impact

Abstract Background Antibiotics are commonly administered in the peripartum period and most patients with penicillin allergy can tolerate beta lactams, which are preferred for the prophylaxis and treatment of several common obstetric infections. The purpose of this study was to evaluate the impact of a stewardship intervention bundle (including updates to institutional antibiotic guidelines, reclassification of severe penicillin allergy, development of order sets, and a physician champion) on the management of obstetric infections in patients with reported penicillin allergy. Methods This was a multicenter, retrospective study of adult patients presenting for labor and delivery who received at least one dose of antibiotics for an infectious indication May 1, 2018 to October 31, 2018 (pre-intervention) and May 1 2020 to October 31, 2020 (post-intervention). The primary outcome was the composite rates of patients with a reported penicillin allergy who received a preferred agent for Group B Streptococcus (GBS) prophylaxis, intraamniotic infection, or cesarean surgical site infection (SSI) prophylaxis. Results A total of 192 patients with a documented penicillin allergy were evaluated (96 patients each in pre- and post-intervention groups). Hives were the most commonly reported allergy in both groups (40% vs 39%, P=0.883). Following stewardship interventions, there was a significant increase in the rate of preferred antibiotics prescribed to patients with penicillin allergy (34.3% vs 84.3%, P< 0.001), driven mainly by patients with non-severe allergy (18.4% vs 82.9%, P< 0.001). There were non-statistically significant trends toward lower rates of postpartum endometritis, 30-day readmission, 90-day SSI, and neonatal early onset sepsis. Allergic reactions in the post-intervention group were limited to itching and rash in one patient each; both resolved with medical management. Conclusion A comprehensive antibiotic stewardship intervention increased preferred antibiotic prescribing for treatment and prophylaxis of obstetric infections. Pregnant patients with non-severe penicillin allergies, even those reporting hives, can tolerate beta-lactam antibiotics. The potential positive impact on clinical outcomes warrants additional investigation. Disclosures Neil Seligman, MD, Natera (Consultant)UpToDate (Other Financial or Material Support, Author)

Management of Group B streptococcus in pregnant women with penicillin allergy

2004 ◽  
Vol 191 (6) ◽  
pp. S57
Author(s):  
Elliot Philipson ◽  
David Lang ◽  
Steven Gordon ◽  
Janet Burlingame ◽  
Stephen Emery ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Group B Streptococcus ◽  
Penicillin Allergy ◽  
Group B

scholarly journals Morbidity in Pregnant Women with Group-B Streptococcus Infection and Unverified Penicillin Allergy

2016 ◽  
Vol 137 (2) ◽  
pp. AB43
Author(s):  
Shilpa Desai ◽  
Qiaoling Chen ◽  
Michael S. Kaplan ◽  
Scott Rasgon ◽  
Eric M. Macy
Keyword(s):  
Pregnant Women ◽  
Group B Streptococcus ◽  
Penicillin Allergy ◽  
Group B

scholarly journals Comparison of various methods for Group B Streptococcus Identification and Cost Comparison

2021 ◽  
Vol 83 (March 2021) ◽  
Author(s):  
Rajeev Nagassar ◽  
Keston Daniel ◽  
RJ Bridgelal-Nagassar
Keyword(s):  
Group B Streptococcus ◽  
Cost Comparison ◽  
Blood Agar ◽  
Group B Streptococci ◽  
Gram Staining ◽  
Resistance Patterns ◽  
Group B ◽  
Utility Cost ◽  
Design And Methods ◽  
Clinic Population

Objectives To verify the utility, cost and feasibility of various methods for Group (Gp) B Streptococcus (GBS) identification; To elucidate the prevalence and resistance patterns of GBS in a clinic population. Design and Methods Isolates were collected from pregnant patients by culturing lower vaginal swabs (LVS) and rectal swabs (RS) from May to September 2015 at Sangre Grande Hospital, Trinidad. These were screened in Carrot Broth (CB), Gram stained and isolated on Blood Agar (BA) and Streptococcus Selective Agar (SSA) simultaneously. Identification was done simultaneously with the Microscan Autoscan® and Streptex® – Streptococcal Grouping kit, to establish concordance. The Microscan Autoscan® panel identified various Streptococcus spp. and Streptex® identified Lancefield Gps A-G. Antimicrobial susceptibility was determined with the Microscan Autoscan® for Gp B Streptococcus only. Discordant isolate identifications between Microscan and Streptex were retained for further analysis. Gram staining was also carried out on negative CB. The total cost of identification of isolates was calculated in Trinidad and Tobago dollars. Results 36 LVS & RS samples were collected: 16 Gp B, 1 Gp C, 11 Gp D & 8 with no Streptococci Gp identification. Prevalence of Gp B Streptococci: 44.4%. Concordance between CB and other methods was 86.1%. Sensitivity: 100%; CI (72% – 100%), Specificity: 80%; CI (59% – 93%). Accuracy: 86.1%; CI (70% – 96%). Microscan Autoscan® and Streptex® identified 100% of isolates correctly. Penicillin resistance was 12.5%, Vancomycin and Clindamycin sensitivity were 100% each. The costs for isolation media plates were – SSA: $ 26 per plate and BA: $18 per plate. Streptococcus identification and sensitivity using Microscan Autoscan® Panel 33: $114 per isolate (with blood agar). Streptococcus identification using Streptex®: $193 per isolate (with blood agar) and Carrot Broth: $49 per isolate. Key Words: Group B Streptococci, Carrot Broth, Microscan, Streptex, SSA, Cost

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