scholarly journals Detection of regional radiation-induced lung injury using hyperpolarized 129 Xe chemical shift imaging in a rat model involving partial lung irradiation: Proof-of-concept demonstration

2017 ◽  
Vol 2 (3) ◽  
pp. 475-484 ◽  
Author(s):  
Brandon Zanette ◽  
Elaine Stirrat ◽  
Salomeh Jelveh ◽  
Andrew Hope ◽  
Giles Santyr
Keyword(s):  
Chemical Shift ◽  
Lung Injury ◽  
Rat Model ◽  
Chemical Shift Imaging ◽  
Proof Of Concept ◽  
Radiation Induced ◽  
Lung Irradiation

Early stage radiation-induced lung injury detected using hyperpolarized 129 Xe Morphometry: Proof-of-concept demonstration in a rat model

2015 ◽  
Vol 75 (6) ◽  
pp. 2421-2431 ◽  
Author(s):  
Alexei Ouriadov ◽  
Matthew Fox ◽  
Elaine Hegarty ◽  
Grace Parraga ◽  
Eugene Wong ◽  
...  
Keyword(s):  
Lung Injury ◽  
Rat Model ◽  
Early Stage ◽  
Proof Of Concept ◽  
Radiation Induced

Chlorine and sodium chemical shift imaging during acute stroke in a rat model at 9.4 Tesla

2013 ◽  
Vol 27 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Sebastian Baier ◽  
Philipp Krämer ◽  
Saskia Grudzenski ◽  
Marc Fatar ◽  
Stefan Kirsch ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Acute Stroke ◽  
Rat Model ◽  
Chemical Shift Imaging

Quantification of regional early stage gas exchange changes using hyperpolarized129Xe MRI in a rat model of radiation-induced lung injury

2016 ◽  
Vol 43 (5) ◽  
pp. 2410-2420 ◽  
Author(s):  
Ozkan Doganay ◽  
Elaine Stirrat ◽  
Charles McKenzie ◽  
Rolf F. Schulte ◽  
Giles E. Santyr
Keyword(s):  
Gas Exchange ◽  
Lung Injury ◽  
Rat Model ◽  
Early Stage ◽  
Radiation Induced

scholarly journals Protection Against Radiation-induced Duox1 and Duox2 Upregulation in Rat’s Lung Tissues by a Combination of Curcumin and L-Selenomethionine

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Masoud Najafi ◽  
Peyman Amini ◽  
Hana Saffar ◽  
Sedighe Kolivand ◽  
Elahe Motevaseli ◽  
...  
Keyword(s):  
Experimental Study ◽  
Free Radicals ◽  
Lung Injury ◽  
Male Rats ◽  
Interleukin 4 ◽  
Injury Treatment ◽  
Radiation Induced ◽  
Lung Irradiation ◽  
Stimulation Of

Background: It has been proposed that increased levels of pro-inflammatory and pro-fibrotic cytokines play a key role in radiation-induced lung injury. Interleukin-4 (IL-4) and IL-13 are two pro-fibrotic cytokines that promote the production of free radicals through stimulation of Duox1 and Duox2. In this experimental study, we aimed to evaluate the expression of IL4Ra1, Duox1, IL13Ra2, and Duox2 genes following rat’s lung irradiation. Objectives: Also, we detected the modulatory effect of a combination of curcumin and L-selenomethionine on the expression of these genes. Methods: Twenty male rats were divided into four groups as G1: control (no treatment or radiation); G2: treatment with a combination of curcumin and L-selenomethionine; G3: radiation; G4: radiation plus a combination of curcumin and L-selenomethionine. sixty-seven days after irradiation, rats were killed for detecting the expression of IL4Ra1, IL13Ra2, Duox1, and Duox2. Results: The results showed no detectable expression for IL13Ra2, while the expression of IL4Ra1, Duox1, and Duox2 was increased. Treatment with a combination of curcumin and L-selenomethionine could attenuate the expression of these genes. Conclusions: This study proposes that upregulation of Duox1 and Duox2 may be involved in radiation-induced lung injury. Treatment with a combination of curcumin and L-selenomethionine may be useful for the mitigation of lung injury through modulation of these genes.

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