scholarly journals Lymphatic changes in cancer and drug delivery to the lymphatics in solid tumors

2019 ◽  
Vol 144 ◽  
pp. 16-34 ◽  
Author(s):  
Brianna Cote ◽  
Deepa Rao ◽  
Raid G. Alany ◽  
Glen S. Kwon ◽  
Adam W.G. Alani
Keyword(s):  
Drug Delivery ◽  
Solid Tumors

scholarly journals Recent Advances in pH- or/and Photo-Responsive Nanovehicles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 725
Author(s):  
Yuseon Shin ◽  
Patihul Husni ◽  
Kioh Kang ◽  
Dayoon Lee ◽  
Sehwa Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Design ◽  
Solid Tumors ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Efficacy And Safety ◽  
Stimulus Responsive ◽  
External Signals

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

scholarly journals Quinic Acid‐Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins

Small ◽  
2018 ◽  
Vol 14 (50) ◽  
pp. 1803601 ◽  
Author(s):  
Jun Xu ◽  
Steve Seung‐Young Lee ◽  
Howon Seo ◽  
Liang Pang ◽  
Yearin Jun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Solid Tumors ◽  
Quinic Acid

scholarly journals Mesenchymal Stem Cells As Guideposts for Nanoparticle-Mediated Targeted Drug Delivery in Ovarian Cancer

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 965
Author(s):  
Buddhadev Layek ◽  
Mihir Shetty ◽  
Susheel Kumar Nethi ◽  
Drishti Sehgal ◽  
Timothy K. Starr ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Solid Tumors ◽  
Efficient Delivery ◽  
Tumor Tissues ◽  
Specific Accumulation ◽  
Targeting Strategy ◽  
High Binding Affinity

Nanocarriers have been extensively utilized for the systemic targeting of various solid tumors and their metastases. However, current drug delivery systems, in general, suffer from a lack of selectivity for tumor cells. Here, we develop a novel two-step targeting strategy that relies on the selective accumulation of targetable synthetic receptors (i.e., azide moieties) in tumor tissues, followed by delivery of drug-loaded nanoparticles having a high binding affinity for these receptors. Mesenchymal stem cells (MSCs) were used as vehicles for the tumor-specific accumulation of azide moieties, while dibenzyl cyclooctyne (DBCO) was used as the targeting ligand. Biodistribution and antitumor efficacy studies were performed in both orthotopic metastatic and patient-derived xenograft (PDX) tumor models of ovarian cancer. Our studies show that nanoparticles are retained in tumors at a significantly higher concentration in mice that received azide-labeled MSCs (MSC-Az). Furthermore, we observed significantly reduced tumor growth (p < 0.05) and improved survival in mice receiving MSC-Az along with paclitaxel-loaded DBCO-functionalized nanoparticles compared to controls. These studies demonstrate the feasibility of a two-step targeting strategy for efficient delivery of concentrated chemotherapy for treating solid tumors.

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