Unraveling the in vivo fate and cellular pharmacokinetics of drug nanocarriers

2019 ◽  
Vol 143 ◽  
pp. 1-2 ◽  
Author(s):  
Wei Wu ◽  
Tonglei Li
Keyword(s):  
Cellular Pharmacokinetics ◽  
Drug Nanocarriers

scholarly journals Synthesis, Principles, and Properties of Magnetite Nanoparticles for In Vivo Imaging Applications—A Review

Pharmaceutics ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 601 ◽  
Author(s):  
Wallyn ◽  
Anton ◽  
Vandamme
Keyword(s):  
Iron Oxide ◽  
Targeted Delivery ◽  
Biomedical Applications ◽  
Colloidal Particles ◽  
Chemical Properties ◽  
Local Drug Delivery ◽  
Physical And Chemical ◽  
Immense Potential ◽  
Drug Nanocarriers

The current nanotechnology era is marked by the emergence of various magnetic inorganic nanometer-sized colloidal particles. These have been extensively applied and hold an immense potential in biomedical applications including, for example, cancer therapy, drug nanocarriers (NCs), or in targeted delivery systems and diagnosis involving two guided-nanoparticles (NPs) as nanoprobes and contrast agents. Considerable efforts have been devoted to designing iron oxide NPs (IONPs) due to their superparamagnetic (SPM) behavior (SPM IONPs or SPIONs) and their large surface-to-volume area allowing more biocompatibility, stealth, and easy bonding to natural biomolecules thanks to grafted ligands, selective-site moieties, and/or organic and inorganic corona shells. Such nanomagnets with adjustable architecture have been the topic of significant progresses since modular designs enable SPIONs to carry out several functions simultaneously such as local drug delivery with real-time monitoring and imaging of the targeted area. Syntheses of SPIONs and adjustments of their physical and chemical properties have been achieved and paved novel routes for a safe use of those tailored magnetic ferrous nanomaterials. Herein we will emphasis a basic notion about NPs magnetism in order to have a better understanding of SPION assets for biomedical applications, then we mainly focus on magnetite iron oxide owing to its outstanding magnetic properties. The general methods of preparation and typical characteristics of magnetite are reviewed, as well as the major biomedical applications of magnetite.

In vivo evaluation of intracellular drug-nanocarriers infused into intracranial tumours by convection-enhanced delivery: distribution and radiosensitisation efficacy

2009 ◽  
Vol 97 (2) ◽  
pp. 195-205 ◽  
Author(s):  
Sandrine Vinchon-Petit ◽  
Delphine Jarnet ◽  
Archibald Paillard ◽  
Jean-Pierre Benoit ◽  
Emmanuel Garcion ◽  
...  
Keyword(s):  
Convection Enhanced Delivery ◽  
In Vivo Evaluation ◽  
Intracranial Tumours ◽  
Drug Nanocarriers

Highly Fluorescent, Photostable, and Ultrasmall Silicon Drug Nanocarriers for Long-Term Tumor Cell Tracking and In-Vivo Cancer Therapy

2014 ◽  
Vol 27 (6) ◽  
pp. 1029-1034 ◽  
Author(s):  
Xiaoyuan Ji ◽  
Fei Peng ◽  
Yiling Zhong ◽  
Yuanyuan Su ◽  
Xiangxu Jiang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Cell ◽  
Cell Tracking ◽  
Drug Nanocarriers

Cellular Pharmacokinetics of Daunomycin in Human Leukemic Blasts In Vitro and In Vivo

Leukemias ◽  
1993 ◽  
pp. 213-218
Author(s):  
M. E. Scheulen ◽  
B. Kramer ◽  
M. Skorzec ◽  
W. K. Reich
Keyword(s):  
Cellular Pharmacokinetics

Cellular pharmacokinetics of daunorubicin: Uptake by leukaemic cells in vivo and fate

1985 ◽  
Vol 29 (1) ◽  
pp. 127-129 ◽  
Author(s):  
V. Trillet ◽  
M. Lakhal ◽  
J. Lang ◽  
E. Perrin-Fayolle ◽  
Q. Timour Chah ◽  
...  
Keyword(s):  
Cellular Pharmacokinetics ◽  
Leukaemic Cells

A Comparative Investigation of the Ability of Various Aptamer-Functionalized Drug Nanocarriers to Induce Selective Apoptosis in Neoplastic Hepatocytes: In Vitro and In Vivo Outcome

2020 ◽  
Vol 21 (3) ◽  
Author(s):  
Samrat Chakraborty ◽  
Zewdu Yilma Dlie ◽  
Biswajit Mukherjee ◽  
Shila Elizabeth Besra ◽  
Soma Sengupta ◽  
...  
Keyword(s):  
Comparative Investigation ◽  
Drug Nanocarriers

scholarly journals Biomimetic Magnetite Nanoparticles as Targeted Drug Nanocarriers and Mediators of Hyperthermia in an Experimental Cancer Model

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2564 ◽  
Author(s):  
Francesca Oltolina ◽  
Ana Peigneux ◽  
Donato Colangelo ◽  
Nausicaa Clemente ◽  
Annarita D’Urso ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Cell Uptake ◽  
Tumor Growth Inhibition ◽  
Cancer Model ◽  
Gradient Magnetic Field ◽  
Experimental Cancer ◽  
Magnetic Nanocarriers ◽  
Drug Nanocarriers ◽  
Mcf 7

Biomimetic magnetic nanoparticles mediated by magnetosome proteins (BMNPs) are potential innovative tools for cancer therapy since, besides being multifunctional platforms, they can be manipulated by an external gradient magnetic field (GMF) and/or an alternating magnetic field (AMF), mediating targeting and hyperthermia, respectively. We evaluated the cytocompatibility/cytotoxicity of BMNPs and Doxorubicin (DOXO)-BMNPs in the presence/absence of GMF in 4T1 and MCF-7 cells as well as their cellular uptake. We analyzed the biocompatibility and in vivo distribution of BMNPs as well as the effect of DOXO-BMNPs in BALB/c mice bearing 4T1 induced mammary carcinomas after applying GMF and AMF. Results: GMF enhanced the cell uptake of both BMNPs and DOXO-BMNPs and the cytotoxicity of DOXO-BMNPs. BMNPs were biocompatible when injected intravenously in BALB/c mice. The application of GMF on 4T1 tumors after each of the repeated (6×) iv administrations of DOXO-BMNPs enhanced tumor growth inhibition when compared to any other treatment, including that with soluble DOXO. Moreover, injection of DOXO-BMNPs in the tumor combined with application of an AMF resulted in a significant tumor weight reduction. These promising results show the suitability of BMNPs as magnetic nanocarriers for local targeted chemotherapy and as local agents for hyperthermia.

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