Top-down fabrication of shape-controlled, monodisperse nanoparticles for biomedical applications

2018 ◽  
Vol 132 ◽  
pp. 169-187 ◽  
Author(s):  
Xinxin Fu ◽  
Jingxuan Cai ◽  
Xiang Zhang ◽  
Wen-Di Li ◽  
Haixiong Ge ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Top Down ◽  
Monodisperse Nanoparticles ◽  
Shape Controlled

Top-Down Processed SOI Nanowire Devices for Biomedical Applications

2019 ◽  
Vol 35 (7) ◽  
pp. 3-15 ◽  
Author(s):  
Sven Ingebrandt ◽  
Xuan-Thang Vu ◽  
Jan Felix Eschermann ◽  
Regina Stockmann ◽  
Andreas Offenhausser
Keyword(s):  
Biomedical Applications ◽  
Top Down

scholarly journals Engineered Microgels—Their Manufacturing and Biomedical Applications

Micromachines ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 45
Author(s):  
Hamzah Alzanbaki ◽  
Manola Moretti ◽  
Charlotte A. E. Hauser
Keyword(s):  
Biomedical Applications ◽  
Attractive Alternative ◽  
Top Down ◽  
Bottom Up ◽  
Advantages And Disadvantages ◽  
Hydrogel Particles ◽  
Self Assembling ◽  
Synthetic Materials ◽  
Micrometer Scale ◽  
Cell Carriers

Microgels are hydrogel particles with diameters in the micrometer scale that can be fabricated in different shapes and sizes. Microgels are increasingly used for biomedical applications and for biofabrication due to their interesting features, such as injectability, modularity, porosity and tunability in respect to size, shape and mechanical properties. Fabrication methods of microgels are divided into two categories, following a top-down or bottom-up approach. Each approach has its own advantages and disadvantages and requires certain sets of materials and equipments. In this review, we discuss fabrication methods of both top-down and bottom-up approaches and point to their advantages as well as their limitations, with more focus on the bottom-up approaches. In addition, the use of microgels for a variety of biomedical applications will be discussed, including microgels for the delivery of therapeutic agents and microgels as cell carriers for the fabrication of 3D bioprinted cell-laden constructs. Microgels made from well-defined synthetic materials with a focus on rationally designed ultrashort peptides are also discussed, because they have been demonstrated to serve as an attractive alternative to much less defined naturally derived materials. Here, we will emphasize the potential and properties of ultrashort self-assembling peptides related to microgels.

scholarly journals Adjusting the length of supramolecular polymer bottlebrushes by top-down approaches

2021 ◽  
Vol 17 ◽  
pp. 2621-2628
Author(s):  
Tobias Klein ◽  
Franka V Gruschwitz ◽  
Maren T Kuchenbrod ◽  
Ivo Nischang ◽  
Stephanie Hoeppener ◽  
...  
Keyword(s):  
Polyethylene Oxide ◽  
Biomedical Applications ◽  
Supramolecular Polymer ◽  
Shear Stresses ◽  
Hydrophobic Core ◽  
Top Down ◽  
Cylindrical Structures ◽  
One Dimensional ◽  
Polymer Nanostructures ◽  
Long Fibers

Controlling the length of one-dimensional (1D) polymer nanostructures remains a key challenge on the way toward the applications of these structures. Here, we demonstrate that top-down processing facilitates a straightforward adjustment of the length of polyethylene oxide (PEO)-based supramolecular polymer bottlebrushes (SPBs) in aqueous solutions. These cylindrical structures self-assemble via directional hydrogen bonds formed by benzenetrisurea (BTU) or benzenetrispeptide (BTP) motifs located within the hydrophobic core of the fiber. A slow transition from different organic solvents to water leads first to the formation of µm-long fibers, which can subsequently be fragmented by ultrasonication or dual asymmetric centrifugation. The latter allows for a better adjustment of applied shear stresses, and thus enables access to differently sized fragments depending on time and rotation rate. Extended sonication and scission analysis further allowed an estimation of tensile strengths of around 16 MPa for both the BTU and BTP systems. In combination with the high kinetic stability of these SPBs, the applied top-down methods represent an easily implementable technique toward 1D polymer nanostructures with an adjustable length in the range of interest for perspective biomedical applications.

scholarly journals Two-Dimensional Borophene: Properties, Fabrication, and Promising Applications

Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-23 ◽  
Author(s):  
Zhongjian Xie ◽  
Xiangying Meng ◽  
Xiangnan Li ◽  
Weiyuan Liang ◽  
Weichun Huang ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
2D Materials ◽  
Chemical Properties ◽  
Two Dimensional ◽  
Spatial Structures ◽  
Top Down ◽  
Bottom Up ◽  
Promising Agent ◽  
Energy Sensor ◽  
Multiple Chemical

Monoelemental two-dimensional (2D) materials (Xenes) aroused a tremendous attention in 2D science owing to their unique properties and extensive applications. Borophene, one emerging and typical Xene, has been regarded as a promising agent for energy, sensor, and biomedical applications. However, the production of borophene is still a challenge because bulk boron has rather intricate spatial structures and multiple chemical properties. In this review, we describe its excellent properties including the optical, electronic, metallic, semiconducting, photoacoustic, and photothermal properties. The fabrication methods of borophene are also presented including the bottom-up fabrication and the top-down fabrication. In the end, the challenges of borophene in the latest applications are presented and perspectives are discussed.

One-pot synthesis of monodisperse iron oxide nanoparticles for potential biomedical applications

2006 ◽  
Vol 78 (5) ◽  
pp. 1003-1014 ◽  
Author(s):  
Jin Xie ◽  
Sheng Peng ◽  
Nathan Brower ◽  
Nader Pourmand ◽  
Shan X. Wang ◽  
...  
Keyword(s):  
Particle Size ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Inverse Spinel ◽  
One Pot ◽  
Inverse Spinel Structure ◽  
Monodisperse Nanoparticles ◽  
Metal Precursors

One-pot reaction of iron(III) acetylacetonate, Fe(acac)3, [or Fe(acac)3 and M(acac)2 where M = Mn and Co], with 1,2-alkanediol, oleic acid, and oleylamine in high boiling organic solvent leads to monodisperse ferrite MFe2O4 nanoparticles. Depending on the concentration of the metal precursors, surfactant-to-metal precursor ratio and the solvent used in the reaction, the particle size from this one-pot reaction can be tuned from 4 to 15 nm. The as-synthesized iron oxide nanoparticles have an inverse spinel structure, and their magnetic properties are controlled by particle size and M in the MFe2O4 structure. The hydrophobic iron oxide nanoparticles are readily transformed into hydrophilic ones by functional phospholipid addition to the as-synthesized particles and as a result, the monodisperse nanoparticles are readily functionalized with biotin, -COOH, -SH, and -NH2, facilitating their link to biomolecules for biomedical applications.

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