3D printed drug delivery and testing systems — a passing fad or the future?

2018 ◽  
Vol 132 ◽  
pp. 139-168 ◽  
Author(s):  
Seng Han Lim ◽  
Himanshu Kathuria ◽  
Justin Jia Yao Tan ◽  
Lifeng Kang
Keyword(s):  
Drug Delivery ◽  
The Future ◽  
3D Printed

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery

2020 ◽  
Vol 13 (4) ◽  
pp. 291-300 ◽  
Author(s):  
Srividya Gorantla ◽  
Tejashree Waghule ◽  
Vamshi Krishna Rapalli ◽  
Prem Prakash Singh ◽  
Sunil Kumar Dubey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Age Related Macular Degeneration ◽  
Stimuli Responsive ◽  
Duration Of Action ◽  
Age Related ◽  
Aqueous Gels ◽  
Ophthalmic Delivery ◽  
3D Printed

Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and others including light, thrombin, pressure, antigen, and glucose-responsive. Incorporation of nanocarriers with these smart stimuli-responsive drug delivery systems that can extend the duration of action by increasing ocular bioavailability and reducing the dosing frequency. This review will focus on the hydrogel drug delivery systems highlighting the gelling mechanisms and emerging stimuli-responsive hydrogels from preformed gels, nanogels, and the role of advanced 3D printed hydrogels in vision-threatening diseases like age-related macular degeneration and retinitis pigmentosa. It also provides insight into the limitations of hydrogels along with the safety and biocompatibility of the hydrogel drug delivery systems.

scholarly journals Nanotechnology, Nanomedicine, and the Kidney

2021 ◽  
Vol 11 (16) ◽  
pp. 7187
Author(s):  
Peter V. Hauser ◽  
Hsiao-Min Chang ◽  
Norimoto Yanagawa ◽  
Morgan Hamon
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Renal Clearance ◽  
Waste Products ◽  
Fluid Homeostasis ◽  
Primary Function ◽  
Drug Removal ◽  
Main Pathway ◽  
The Future

The kidneys are vital organs performing several essential functions. Their primary function is the filtration of blood and the removal of metabolic waste products as well as fluid homeostasis. Renal filtration is the main pathway for drug removal, highlighting the importance of this organ to the growing field of nanomedicine. The kidneys (i) have a key role in the transport and clearance of nanoparticles (NPs), (ii) are exposed to potential NPs’ toxicity, and (iii) are the targets of diseases that nanomedicine can study, detect, and treat. In this review, we aim to summarize the latest research on kidney-nanoparticle interaction. We first give a brief overview of the kidney’s anatomy and renal filtration, describe how nanoparticle characteristics influence their renal clearance, and the approaches taken to image and treat the kidney, including drug delivery and tissue engineering. Finally, we discuss the future and some of the challenges faced by nanomedicine.

scholarly journals A Novel 3D Printed Hollow Microneedle Microelectromechanical System for Controlled, Personalised Transdermal Drug Delivery

2020 ◽  
pp. 101815
Author(s):  
Sophia N. Economidou ◽  
Md. Jasim Uddin ◽  
Manuel J. Marques ◽  
Dennis Douroumis ◽  
Wan Ting Sow ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Microelectromechanical System ◽  
Hollow Microneedle ◽  
3D Printed

scholarly journals Tuning the Thermogelation and Rheology of Poly(2-Oxazoline)/poly(2-Oxazine)s Based Thermosensitive Hydrogels for 3D Bioprinting.

2021 ◽  
Author(s):  
Malik Salman Haider ◽  
Taufiq Ahmad ◽  
Mengshi Yang ◽  
Chen Hu ◽  
Lukas Hahn ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Gel Strength ◽  
Adipose Derived Stem Cells ◽  
3D Bioprinting ◽  
Thermosensitive Hydrogel ◽  
Clay Nanoparticles ◽  
Hydrogel Matrix ◽  
Thermosensitive Hydrogels ◽  
3D Printed

As one kind of smart material, thermogelling polymers find applications in biofabrication, drug delivery and regenerative medicine. Here, we reported on a novel thermosensitive hydrogel which can be 3D printed using extrusion based printing. Gel strength was found around 3kPa storage modulus with pronounced shear thinning and rapid recovery after stress. Addition of clay nanoparticles (Laponite XLG) improved the rheological profile further. Human adipose derived stem cells were added to the hydrogel matrix, which remained fully viable after printing. Therefore, the presented materials adds to the available material toolbox for 3D bioprinting. <br>

The rise of transcutaneous drug delivery for the management of alopecia: a review of existing literature and an eye towards the future

2018 ◽  
Vol 21 (5) ◽  
pp. 247-254 ◽  
Author(s):  
Angela Wipf ◽  
Nicholas Boysen ◽  
Maria K. Hordinsky ◽  
Emily E. Dando ◽  
Neil Sadick ◽  
...  
Keyword(s):  
Drug Delivery ◽  
The Future ◽  
Transcutaneous Drug Delivery

scholarly journals A novel amphiphilic fluorescent probe BODIPY–O-CMC–cRGD as a biomarker and nanoparticle vector

RSC Advances ◽  
2018 ◽  
Vol 8 (36) ◽  
pp. 20087-20094 ◽  
Author(s):  
Tingting Zhu ◽  
Ji Xiong ◽  
Zhongbo Xue ◽  
Yu Su ◽  
Fengnan Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescent Probe ◽  
Fluorescence Probe ◽  
Drug Delivery Vehicles ◽  
The Future ◽  
Delivery Vehicles

The amphipathic fluorescence probe, BODIPY–O-CMC–cRGD, can be applied in visualized diagnoses and as drug delivery vehicles of visualized therapies in the future.

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