Recent advances on anti-HIV vaginal delivery systems development

2015 ◽  
Vol 92 ◽  
pp. 123-145 ◽  
Author(s):  
Sophia G. Antimisiaris ◽  
Spyridon Mourtas
Keyword(s):  
Vaginal Delivery ◽  
Systems Development ◽  
Delivery Systems ◽  
Recent Advances ◽  
Vaginal Delivery Systems ◽  
Anti Hiv

scholarly journals Characteristics of vaginal delivery systems

2017 ◽  
Vol 67 (6) ◽  
pp. 360-377
Author(s):  
Milica Filipović ◽  
Ljiljana Đekić
Keyword(s):  
Vaginal Delivery ◽  
Delivery Systems ◽  
Vaginal Delivery Systems

Novel vaginal delivery systems for calcitonin: II. Preparation and characterization of HYAFF® microspheres containing calcitonin

1996 ◽  
Vol 144 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Maria Rochira ◽  
Maria Rosaria Miglietta ◽  
Julie L. Richardson ◽  
Luca Ferrari ◽  
Mauro Beccaro ◽  
...  
Keyword(s):  
Vaginal Delivery ◽  
Delivery Systems ◽  
Vaginal Delivery Systems

Recent Advances on Vaginal delivery for the Treatment of Vulvovaginal candidiasis

2020 ◽  
Vol 13 ◽  
Author(s):  
Sandeep Kaur ◽  
Sukhbir Kaur
Keyword(s):  
Vaginal Delivery ◽  
Residence Time ◽  
Antifungal Agents ◽  
Delivery Systems ◽  
Vulvovaginal Candidiasis ◽  
Sexual Activities ◽  
Mucoadhesive Polymers ◽  
Effective Delivery ◽  
Vaginal Delivery Systems ◽  
Treatment Of Infection

Background: Vulvovaginal candidiasis (VVC) is a common vaginal infection caused by candida species, affecting 70% of the women. It may occur due to the imbalance in the vaginal micro-biodata, pregnancy, diabetes, use of antibiotics, frequent sexual activities or AIDS. Aim: The main aim of this review is to provide overview about different vaginal delivery systems for the administration of antifungal agents like conventional, mucoadhesive and muco-penetrating delivery systems. Method: The conventional delivery systems available are having limited efficacy due to the less residence time and adverse effects. In order to overcome these issues, delivery system with mucoadhesive and muco-penetrating properties is required. Mucoadhesive polymers are having excellent binding properties with mucin and thus increasing residence time. On the other hand, muco-penetrating polymers transport the antifungal agents across the mucus layer. Results: This review summarizes the pathophysiology of VVC along with novel delivery systems for the treatment of infection through mucoadhesive and muco-penetrating approaches. Surface modifications of nano/ microparticles with mucoadhesive or muco-penetrating particles may results delivery systems with improved therapeutic efficacy. Conclusion: Based on the available data conventional and mucoadhesive drug delivery systems have some limitations, still requires improvement/ development for safe and effective delivery of antifungal agents.

Novel vaginal delivery systems for calcitonin: I. Evaluation of HYAFF/calcitonin microspheres in rats

1995 ◽  
Vol 115 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Julie L. Richardson ◽  
Piera Angela Ramires ◽  
Maria Rosaria Miglietta ◽  
Maria Rochira ◽  
L. Bacelle ◽  
...  
Keyword(s):  
Vaginal Delivery ◽  
Delivery Systems ◽  
Vaginal Delivery Systems

Gelatin–PEG based metronidazole-loaded vaginal delivery systems: preparation, characterization and in vitro antimicrobial efficiency

2014 ◽  
Vol 23 (3) ◽  
pp. 171-184 ◽  
Author(s):  
S. M. Khade ◽  
B. Behera ◽  
S. S. Sagiri ◽  
V. K. Singh ◽  
A. Thirugnanam ◽  
...  
Keyword(s):  
Vaginal Delivery ◽  
Delivery Systems ◽  
Antimicrobial Efficiency ◽  
Vaginal Delivery Systems

Recent Advances of Mesoporous Silica Based Multifunctional Nano Drug Delivery Systems

2013 ◽  
Vol 40 (10) ◽  
pp. 1014
Author(s):  
Xiao-Hong HAO ◽  
Cui-Miao ZHANG ◽  
Xiao-Long LIU ◽  
Xing-Jie LIANG ◽  
Guang JIA ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Recent Advances ◽  
Nano Drug Delivery

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

Synthetic Strategies, Chemical Reactivities and Biological Activities of 3-Thioxo-1,2,4-Triazin-5-Ones and Their Derivatives

2019 ◽  
Vol 16 (4) ◽  
pp. 308-322
Author(s):  
Mohammad S.T. Makki ◽  
Reda M. Abdel-Rahman ◽  
Abdulrahman S. Alharbi
Keyword(s):  
Biological Activities ◽  
Biological Evaluation ◽  
Literature Survey ◽  
Recent Advances ◽  
Nucleophilic Reagents ◽  
Anti Hiv ◽  
Biological Field

In recent years, a very interest in the synthesis of functionalized 3-thioxo-1,2,4-triazin-5- ones and their derivatives as vital probes has been increased, due to the important, applications of the medicinal, pharmacological, and biological field as a drug, semi drug, and bioactive systems. The present work review outlines extensive recent advances literature survey on the synthesis of sulfurbearing 1,2,4-triazin-5-one derivatives has been reconsidered. Also, the behavior of these family towards electrophilic and nucleophilic reagents in different media and conditions reported. The biological evaluation of the most synthesized systems included anticancer, anti-HIV, antimicrobial as well as their enzymatic effects (cellobiase produced by fungi) have been reported. The reactivity of these systems depends on the polarity of solvent, temperature, molarity as well as a type of tautomeric present.

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