Magnetic resonance guided high-intensity focused ultrasound for image-guided temperature-induced drug delivery

2014 ◽  
Vol 72 ◽  
pp. 65-81 ◽  
Author(s):  
Nicole Hijnen ◽  
Sander Langereis ◽  
Holger Grüll
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Image Guided

scholarly journals Mild hyperthermia with magnetic resonance-guided high-intensity focused ultrasound for applications in drug delivery

2012 ◽  
Vol 28 (4) ◽  
pp. 320-336 ◽  
Author(s):  
Ari Partanen ◽  
Pavel S. Yarmolenko ◽  
Antti Viitala ◽  
Sunil Appanaboyina ◽  
Dieter Haemmerich ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Mild Hyperthermia

scholarly journals Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound

2017 ◽  
Vol 114 (24) ◽  
pp. E4802-E4811 ◽  
Author(s):  
Nicole Hijnen ◽  
Esther Kneepkens ◽  
Mariska de Smet ◽  
Sander Langereis ◽  
Edwin Heijman ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Drug Delivery ◽  
Magnetic Resonance ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Emission Computed Tomography ◽  
Treatment Groups ◽  
Drug Concentrations ◽  
Rat Tumor Model

Several thermal-therapy strategies such as thermal ablation, hyperthermia-triggered drug delivery from temperature-sensitive liposomes (TSLs), and combinations of the above were investigated in a rhabdomyosarcoma rat tumor model (n = 113). Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) was used as a noninvasive heating device with precise temperature control for image-guided drug delivery. For the latter, TSLs were prepared, coencapsulating doxorubicin (dox) and [Gd(HPDO3A)(H2O)], and injected in tumor-bearing rats before MR-HIFU treatment. Four treatment groups were defined: hyperthermia, ablation, hyperthermia followed by ablation, or no HIFU. The intratumoral TSL and dox distribution were analyzed by single-photon emission computed tomography (SPECT)/computed tomography (CT), autoradiography, and fluorescence microscopy. Dox biodistribution was quantified and compared with that of nonliposomal dox. Finally, the treatment efficacy of all heating strategies plus additional control groups (saline, free dox, and Caelyx) was assessed by tumor growth measurements. All HIFU heating strategies combined with TSLs resulted in cellular uptake of dox deep into the interstitial space and a significant increase of tumor drug concentrations compared with a treatment with free dox. Ablation after TSL injection showed [Gd(HPDO3A)(H2O)] and dox release along the tumor rim, mirroring the TSL distribution pattern. Hyperthermia either as standalone treatment or before ablation ensured homogeneous TSL, [Gd(HPDO3A)(H2O)], and dox delivery across the tumor. The combination of hyperthermia-triggered drug delivery followed by ablation showed the best therapeutic outcome compared with all other treatment groups due to direct induction of thermal necrosis in the tumor core and efficient drug delivery to the tumor rim.

SPECT/CT imaging of temperature-sensitive liposomes for MR-image guided drug delivery with high intensity focused ultrasound

2013 ◽  
Vol 169 (1-2) ◽  
pp. 82-90 ◽  
Author(s):  
Mariska de Smet ◽  
Sander Langereis ◽  
Sandra van den Bosch ◽  
Katrin Bitter ◽  
Nicole M. Hijnen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Ct Imaging ◽  
High Intensity Focused Ultrasound ◽  
Temperature Sensitive ◽  
Mr Image ◽  
Image Guided ◽  
Image Guided Drug Delivery
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