Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides

2007 ◽  
Vol 59 (2-3) ◽  
pp. 134-140 ◽  
Author(s):  
Bryan R. Meade ◽  
Steven F. Dowdy
Keyword(s):  
Sirna Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating ◽  
Peptide Transduction

Cell-penetrating peptides for siRNA delivery to glioblastomas

Peptides ◽  
2018 ◽  
Vol 104 ◽  
pp. 62-69 ◽  
Author(s):  
Artita Srimanee ◽  
Maria Arvanitidou ◽  
Kumjee Kim ◽  
Mattias Hällbrink ◽  
Ülo Langel
Keyword(s):  
Sirna Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

scholarly journals Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery

2017 ◽  
Vol 8 ◽  
pp. 264-276 ◽  
Author(s):  
Martina Tuttolomondo ◽  
Cinzia Casella ◽  
Pernille Lund Hansen ◽  
Ester Polo ◽  
Luciana M. Herda ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

scholarly journals Comparison of the Efficiency of Complexes Based on S413-PV Cell-Penetrating Peptides in Plasmid DNA and siRNA Delivery

2013 ◽  
Vol 10 (7) ◽  
pp. 2653-2666 ◽  
Author(s):  
Ana M. Cardoso ◽  
Sara Trabulo ◽  
Ana L. Cardoso ◽  
Sílvia Maia ◽  
Paula Gomes ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Sirna Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating ◽  
Pv Cell

scholarly journals siRNA Delivery: From Lipids to Cell-penetrating Peptides and Their Mimics

2012 ◽  
Vol 80 (6) ◽  
pp. 787-809 ◽  
Author(s):  
Matt Gooding ◽  
Lorcan P. Browne ◽  
Filipa M. Quinteiro ◽  
David L. Selwood
Keyword(s):  
Sirna Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

Perspectives and Challenges of Cell-Penetrating Peptides in Effective siRNA Delivery

Nano LIFE ◽  
2014 ◽  
Vol 04 (04) ◽  
pp. 1441016 ◽  
Author(s):  
Zhiqiang Yu ◽  
Bin Yu ◽  
Justin Boy Kaye ◽  
Chenhong Tang ◽  
Shengxi Chen ◽  
...  
Keyword(s):  
Delivery System ◽  
Sirna Delivery ◽  
Cell Penetrating Peptides ◽  
Bioactive Molecules ◽  
Nucleic Acid Delivery ◽  
Cellular Delivery ◽  
Advantages And Disadvantages ◽  
Efficient Delivery ◽  
Wide Range ◽  
Cell Penetrating

Over the last two decades, hundreds of cell penetrating peptides (CPPs) have been intensively developed as drug and nucleic acid delivery vectors. In many cases, however, the efficient delivery of exogenous bioactive molecules through the plasma membrane to their targets remains a tremendous challenging issue. CPPs have attracted tremendous research interest as efficient cellular delivery vehicles due to their intrinsic ability to enter cells and mediate uptake of a wide range of macromolecular cargos, such as proteins, peptides, nucleic acids, drugs and nanoparticle carriers. This review presents and discusses the current perspectives of CPP-mediated siRNA delivery system. We focus on the CPP-mediated siRNA delivery approaches, and particular emphasis is placed on the strategies for the advantages and disadvantages for each delivery approach. Lastly, the cellular uptake mechanisms of CPPs and the specific challenges associated with each delivery system of siRNAs are discussed.

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