Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake

2004 ◽  
Vol 56 (9) ◽  
pp. 1315-1334 ◽  
Author(s):  
Nancy S. Chung ◽  
Kishor M. Wasan
Keyword(s):  
Potential Role ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Drug Uptake ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Low Density Lipoprotein Receptor ◽  
Density Lipoprotein Receptor ◽  
Receptor Family

scholarly journals Lipoprotein receptor signalling in atherosclerosis

2019 ◽  
Vol 116 (7) ◽  
pp. 1254-1274 ◽  
Author(s):  
Chieko Mineo
Keyword(s):  
Low Density Lipoprotein ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Type I ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Low Density Lipoprotein Receptor ◽  
Lipoprotein Receptors ◽  
Density Lipoprotein Receptor ◽  
Receptor Family

Abstract The founding member of the lipoprotein receptor family, low-density lipoprotein receptor (LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis of LDL particles and regulation of cholesterol homeostasis. Since the discovery of the LDLR, many other structurally and functionally related receptors have been identified, which include low-density lipoprotein receptor-related protein (LRP)1, LRP5, LRP6, very low-density lipoprotein receptor, and apolipoprotein E receptor 2. The scavenger receptor family members, on the other hand, constitute a family of pattern recognition proteins that are structurally diverse and recognize a wide array of ligands, including oxidized LDL. Among these are cluster of differentiation 36, scavenger receptor class B type I and lectin-like oxidized low-density lipoprotein receptor-1. In addition to the initially assigned role as a mediator of the uptake of macromolecules into the cell, a large number of studies in cultured cells and in in vivo animal models have revealed that these lipoprotein receptors participate in signal transduction to modulate cellular functions. This review highlights the signalling pathways by which these receptors influence the process of atherosclerosis development, focusing on their roles in the vascular cells, such as macrophages, endothelial cells, smooth muscle cells, and platelets. Human genetics of the receptors is also discussed to further provide the relevance to cardiovascular disease risks in humans. Further knowledge of the vascular biology of the lipoprotein receptors and their ligands will potentially enhance our ability to harness the mechanism to develop novel prophylactic and therapeutic strategies against cardiovascular diseases.

Potential Roles for the Low Density Lipoprotein Receptor Family of Proteins in Implantation and Placentation

1994 ◽  
Vol 734 (1 The Human End) ◽  
pp. 91-102 ◽  
Author(s):  
GEORGE COUKOS ◽  
MATS E. GÅFVELS ◽  
FRANK WITTMAACK ◽  
HIROYA MATSUO ◽  
DUDLEY K. STRICKLAND ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Low Density Lipoprotein Receptor ◽  
Density Lipoprotein Receptor ◽  
Receptor Family
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