Photodynamic therapy of skin cancer: controlled drug delivery of 5-ALA and its esters

2004 ◽  
Vol 56 (1) ◽  
pp. 77-94 ◽  
Author(s):  
R Lopez
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Skin Cancer ◽  
Controlled Drug Delivery

scholarly journals Bacterial Cellulose Membranes as a Potential Drug Delivery System for Photodynamic Therapy of Skin Cancer

2016 ◽  
Author(s):  
Maristela de F. S. Peres ◽  
Karina Nigoghossian ◽  
Fernando L. Primo ◽  
Sybele Saska ◽  
Ticiana S. de O. Capote ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Skin Cancer ◽  
Bacterial Cellulose ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Drug ◽  
Cellulose Membranes

scholarly journals Strategies to Improve Drug Delivery in Topical PDT

2021 ◽  
Author(s):  
Michelle Barreto Requena ◽  
Mirian Denise Stringasci ◽  
José Dirceu Vollet-Filho ◽  
Vanderlei Salvador Bagnato
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Photodynamic Therapy ◽  
Skin Cancer ◽  
Actinic Keratosis ◽  
Animal Studies ◽  
Limiting Factor ◽  
Non Melanoma Skin Cancer ◽  
Malignant Lesions ◽  
Melanoma Skin

Topical photodynamic therapy (PDT) has been applied to treat premalignant and malignant lesions such as actinic keratosis and non-melanoma skin cancer. A limiting factor of the technique is cream permeation and studies using chemical and physical approaches to overcome it have increased over the years. This chapter is going to explore the main techniques described in the literature used to improve the cream permeation or the photosensitizer (PS) distribution concerning homogeneity. Outcomes-based on animal studies and clinical trials comparing different delivery techniques are going to be presented, highlighting the aspects of invasiveness, costs, harmfulness, and effectiveness of those methods.

Innovative Drug Delivery Strategies for Topical Photodynamic Therapy using Porphyrin Precursors

2007 ◽  
Vol 26 (2) ◽  
pp. 105-116 ◽  
Author(s):  
Desmond I. J. Morrow ◽  
Martin J. Garland ◽  
Paul A. McCarron ◽  
A. David Woolfson ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Innovative Drug ◽  
Delivery Strategies

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Sign in / Sign up

Export Citation Format

Share Document