scholarly journals Implantable cardioverter-defibrillators in end-stage heart failure patients listed for heart transplantation: Results from a large retrospective registry

2016 ◽  
Vol 109 (8-9) ◽  
pp. 476-485 ◽  
Author(s):  
Estelle Gandjbakhch ◽  
Marion Rovani ◽  
Shaida Varnous ◽  
Carole Maupain ◽  
Thomas Chastre ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Transplantation ◽  
Implantable Cardioverter Defibrillators ◽  
Heart Failure Patients ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Cardioverter Defibrillators

Effect of heart transplantation on skeletal muscle metabolic enzyme reserve and fiber type in end-stage heart failure patients

2007 ◽  
Vol 21 (1) ◽  
pp. 94-100 ◽  
Author(s):  
Gary L. Pierce ◽  
Peter M. Magyari ◽  
Juan M. Aranda ◽  
David G. Edwards ◽  
Scott A. Hamlin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Heart Transplantation ◽  
Fiber Type ◽  
Metabolic Enzyme ◽  
Heart Failure Patients ◽  
End Stage Heart Failure ◽  
End Stage

Abstract 14797: Pediatric Arrhythmogenic Ventricular Cardiomyopathy Often Misclassified in End Stage Heart Failure Patients - A 30 Year Tertiary Care Center Experience

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Swati Choudhry ◽  
Debra L Kearney ◽  
Kyle D Hope ◽  
Hari P Tunuguntla ◽  
Joseph Spinner ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ventricular Arrhythmia ◽  
Heart Transplantation ◽  
Heart Transplant ◽  
Restrictive Cardiomyopathy ◽  
Young Population ◽  
Ventricular Cardiomyopathy ◽  
Heart Failure Patients ◽  
End Stage Heart Failure ◽  
End Stage

Introduction and Background: Arrhythmogenic ventricular cardiomyopathy (AVC) is a hereditable disorder characterized by fibro-fatty infiltration of the right ventricular myocardial wall. The purpose of this study was to describe the clinicopathologic phenotype of AVC in pediatric end-stage heart failure patients who underwent heart transplantation (HTx). Hypothesis: We hypothesized that AVC is misclassified in the young population who require heart transplant. Methods: We investigated 371 consecutive cases of primary pediatric (≤21 years) heart transplantation performed at Texas Children’s hospital between 1989 and 2018. Heart re-transplants were excluded from the study. Explanted hearts and tissue blocks were examined by a cardiac pathologist after HTx. Histological Diagnosis of AVC was based on the presence of major and minor diagnostic criteria according to the 2010 Revised Task Force Criteria. Results: Over half of the patients who underwent HTx had cardiomyopathy (212/371=57%) as the underlying primary diagnosis. After comprehensive histological evaluation of explanted hearts, 8 cases (8/212=3.8%) were diagnosed with AVC. Predominantly right ventricular disease was seen in 2/8 (25%), and biventricular involvement in 6/8 (75%) patients on pathological examination. Six out of 8 patients (6/8=75%) were misclassified, 4 as dilated cardiomyopathy, 1 as viral myocarditis, and 1 as restrictive cardiomyopathy. The median age at heart transplant (AVC cohort) was 11 years. Four of 8 (50%) were males. Six of 8 (75%) had a significant ventricular arrhythmia burden manifesting as non-sustained ventricular tachycardia requiring antiarrhythmic therapy. Genetic testing was undertaken in 3 of 8 (37.5%); all three were found to have pathogenic mutations in the PKP2 gene. Conclusion: Arrhythmogenic ventricular cardiomyopathy is often misclassified in the young population who require heart transplant. Pediatric dilated and restrictive cardiomyopathy phenotypes with end-stage heart failure waitlisted for a heart transplant (HT) who have a significant ventricular arrhythmia burden should be investigated for AVC.

Destination therapy: an alternative for end-stage heart failure patients not eligible for heart transplantation

2005 ◽  
Vol 10 (4) ◽  
pp. 369-375 ◽  
Author(s):  
Martin Cadeiras ◽  
Manuel Prinz Von Bayern ◽  
Amandeep Pal ◽  
Tomohiro Asai ◽  
Yoshifumi Naka ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Transplantation ◽  
Destination Therapy ◽  
Heart Failure Patients ◽  
End Stage Heart Failure ◽  
End Stage
Sign in / Sign up

Export Citation Format

Share Document