scholarly journals Pulmonary artery dissection as a rare complication of pulmonary hypertension

2012 ◽  
Vol 105 (12) ◽  
pp. 676-677 ◽  
Author(s):  
Fabrice Bauer ◽  
Mathieu Lemercier ◽  
Jean-Nicolas Dacher
2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
E Gotti ◽  
M Palazzini ◽  
F Saia ◽  
F Dardi ◽  
A Rinaldi ◽  
...  

Abstract Background Balloon pulmonary angioplasty (BPA) has recently been developed as an alternative and less-invasive treatment strategy for chronic thromboembolic pulmonary hypertension (CTEPH) but therapeutic efficacy and technical safety of the technique have to be established. Purpose To examine the effects of BPA on patients with inoperable disease or residual pulmonary hypertension (PH) after pulmonary endarterectomy (PEA). Methods From June 2015 to January 2019 we enrolled symptomatic (WHO-FC ≥II) inoperable CTEPH patients and patients with residual PH after PEA. At baseline and after 3 months after last BPA session all patients underwent clinical evaluation, six-minute walking distance (6MWD) and right heart catheterization. For comparisons Friedman test (with Bonferroni post-hoc pairwise analysis) was used. Results Forty-one patients [male 49%, median age 65 (52–75) years, 34 inoperable and 7 with residual PH after PEA] were treated for a total of 111 sessions (median number of sessions for each patient: 2); during each session we treated 2 (2.0–2.5) vessels. Results are shown in the Table. Forty patients were treated with medical therapy before BPA (16 with combination therapy). Four pulmonary artery dissection and 2 haemoptysis with clinical impairment were documented during the procedures; 27 patients had lung injury (radiographic opacity with/without hemoptysis and/or hypoxemia), none had renal dysfunction, 6 patients had access site complications. Five patients died during follow-up (none within 30 days from the procedure) because of sepsis (1), heart failure (1), cancer (1), arrhythmic storm (1) and sudden death in a patients with severe coronary atherosclerosis (1). Table 1 Median (interquartile range) Baseline Baseline ÷ Pre-BPA Pre-BPA Pre-BPA ÷ Post-BPA Post-BPA Global (n=41) 8 (3–49) months (n=41) 10 (6–18) months (n=32) p-value WHO-FC III-IV (%) 88 N.S. 83 <0.05 42 <0.001 6MWD (m) 430 (346–560) N.S. 425 (357–500) <0.05 450 (375–605) <0.001 RAP (mmHg) 6 (5–8) N.S. 6 (5–8) N.S. 6 (4–8) 0.023 mPAP (mmHg) 46 (40–52) <0.05 43 (33–50) <0.05 36 (28–41) <0.001 CI (l/min/m2) 2.6 (2.2–3.0) N.S. 2.7 (2.2–3.0) <0.05 3.1 (2.6–3.5) 0.004 PVR (WU) 7.5 (5.6–11.5) <0.05 6.5 (4.7–10.3) <0.05 4.1 (3.3–5.9) <0.001 PA O2 Sat (%) 69 (63–71) N.S. 69 (63–72) N.S. 69 (63–73) 0.002 CI, Cardiac Index; mPAP, mean Pulmonary Arterial Pressure; PVR, Pulmonary Vascular Resistance; PA O2 Sat, Pulmonary Artery Oxygen Saturation; RAP, Right Atrial Pressure; 6MWD, 6 Minute Walking Distance; WHO-FC, World Health Organization Functional Class. Conclusions BPA is a safe and effective treatment able to improve symptoms and hemodynamic profile in inoperable CTEPH patients and in patients with residual PH after PEA. Acknowledgement/Funding None


2013 ◽  
Vol 4 (5) ◽  
pp. 483-485 ◽  
Author(s):  
Yasin Ay ◽  
Nuray Kahraman Ay ◽  
Cemalettin Aydin ◽  
Ibrahim Kara ◽  
Rahmi Zeybek

2006 ◽  
Vol 81 (1) ◽  
pp. 360-362 ◽  
Author(s):  
Yasushi Sakamaki ◽  
Masato Minami ◽  
Mitsunori Ohta ◽  
Toshiki Takahashi ◽  
Goro Matsumiya ◽  
...  

2021 ◽  
Vol 233 ◽  
pp. 02002
Author(s):  
Jiang Jinyan ◽  
Li Jin ling ◽  
Chengjie

Connective Tissue Disease (CTD) is an autoimmune disease involving connective tissues, including sjogren syndrome (pSS), rheumatoid arthritis (RA), systemic sclerosis (SSc), mixed connective tissue disease (MCTD), systemic lupus erythematosus (SLE), etc. [1,2]. Pulmonary Arterial Hypertension (PAH) refers to a pathological condition in which the pulmonary artery pressure rises above a certain threshold, causing right heart failure and death [3]. PAH refers to the mean Pulmonary Artery Pressure (mPAP) of greater than 25 mmHg and the pulmonary wedge pressure (PAWP) of less than 15mmhg under right heart catheterization (RHC) at rest [4,5]. The only criterion for examining pulmonary hypertension is right cardiac catheterization. Connective tissue disease-associated pulmonary hypertension (CTD-PAH) is a rare complication of PAH, characterized by high mortality, venous and cardiac involvement and poor prognosis [6-8].


Heart & Lung ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 453-457 ◽  
Author(s):  
Carl Johan Malm ◽  
Lisa Ternström ◽  
Kirsten Jörgensen ◽  
Göran Dellgren

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