Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats

2006 ◽  
Vol 108 (5) ◽  
pp. 365-371 ◽  
Author(s):  
Alaadin Polat ◽  
Hakan Parlakpinar ◽  
Seda Tasdemir ◽  
Cemil Colak ◽  
Nigar Vardi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Role

Protective role of the inhibitor of apoptosis protein, survivin, in toxin‐induced acute renal failure

2007 ◽  
Vol 22 (2) ◽  
pp. 510-521 ◽  
Author(s):  
Nele Kindt ◽  
Axel Menzebach ◽  
Marlies Van de Wouwer ◽  
Inge Betz ◽  
Astrid De Vriese ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Role ◽  
Inhibitor Of Apoptosis ◽  
Inhibitor Of Apoptosis Protein ◽  
Apoptosis Protein

Protective Role of Furosemide and Saline in Radiocontrast-Induced Acute Renal Failure in the Rat

1989 ◽  
Vol 14 (5) ◽  
pp. 377-385 ◽  
Author(s):  
Samuel N. Heyman ◽  
Mayer Brezis ◽  
Ziv Greenfeld ◽  
Seymour Rosen
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Role

Role of glomerular nitric oxide in glycerol-induced acute renal failure

2000 ◽  
Vol 78 (6) ◽  
pp. 476-482 ◽  
Author(s):  
J M Valdivielso ◽  
JM López-Novoa ◽  
N Eleno ◽  
F Pérez Barriocanal
Keyword(s):  
Nitric Oxide ◽  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Study Groups ◽  
Protective Role ◽  
Nitrite Production ◽  
Glycerol Injection ◽  
Clinical Syndromes

Myoglobinuric acute renal failure remains one of the least understood clinical syndromes and the mediators involved remain obscure. The aim of the present study was to assess the role of nitric oxide in glycerol-induced acute renal failure under normal conditions and after uninephrectomy. Acute renal failure was induced in rats by injection of 50% glycerol (10 mL·kg-1 body weight). Half of the animals were subjected to uninephrectomy two days before glycerol injection. Two days after the induction of acute renal failure, glomeruli from some animals were isolated and glomerular nitrite production was measured. Another group of animals was used for acute clearance studies. In this case, the effect of infusing either L-NAME or L-arginine was assayed. Glomerular nitrite production was significantly decreased in glycerol-induced acute renal failure. Glomeruli from uninephrectomized animals showed an increase in nitrite production, both in normal conditions and after glycerol injection, as compared with glomeruli from non-nephrectomized animals. L-NAME infusion worsened renal function in all the study groups, but more slowly in animals with glycerol-induced acute renal failure than in control rats. In uninephrectomized animals L-NAME reduced renal function more than in animals with two kidneys. In conclusion, in this model of acute renal failure the decrease in glomerular nitric oxide production plays an important role in the decrease in renal function. After uninephrectomy, an increase in glomerular nitric oxide synthesis plays a protective role against glycerol-induced acute renal failure.Key words: acute renal failure, nitric oxide, glycerol, glomeruli.

scholarly journals Evaluating role of oxidative stress in determining the pathogenesis of falciparum malaria induced acute renal failure

2004 ◽  
Vol 19 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Rachita Nanda ◽  
Pramila K. Mishra ◽  
U. K. Das ◽  
S. B. Rout ◽  
P. C. Mohapatra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Falciparum Malaria

Role of N-Acetylcysteine in the Prevention of Radiocontrast-Induced Nephropathy

2002 ◽  
Vol 36 (9) ◽  
pp. 1466-1470 ◽  
Author(s):  
Donald F Brophy
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Large Scale ◽  
English Language ◽  
Small Animal ◽  
Human Studies ◽  
Animal Trials ◽  
Study Selection ◽  
Risk Patients

OBJECTIVE: To examine the role of N-acetylcysteine (NAC) in the prevention of radiocontrast—induced nephropathy (RIN). DATA SOURCES: A literature search of MEDLINE (1966–December 2001) was performed using the following search terms: N-acetylcysteine, nephropathy, acute renal failure, and radiocontrast. STUDY SELECTION: Pertinent English-language animal and human studies were reviewed. DATA SYNTHESIS: Few small animal trials have demonstrated that NAC significantly prevents the development or reduces the severity of acute renal failure. Two human studies demonstrated NAC significantly reduces the occurrence of RIN. CONCLUSIONS: NAC may reduce the occurrence of RIN in high-risk patients. Further large-scale studies are needed to corroborate findings from earlier trials.

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