scholarly journals Effect of age on biomaterial-mediated in situ bone tissue regeneration

2018 ◽  
Vol 78 ◽  
pp. 329-340 ◽  
Author(s):  
Mengqian Liu ◽  
Manando Nakasaki ◽  
Yu-Ru Vernon Shih ◽  
Shyni Varghese
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Effect Of Age

scholarly journals Preparation and characterization of a novel composite membrane of natural silk fiber/nano-hydroxyapatite/chitosan for guided bone tissue regeneration

e-Polymers ◽  
2021 ◽  
Vol 21 (1) ◽  
pp. 671-680
Author(s):  
Shuo Tang ◽  
Weijia Wang
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Composite Membrane ◽  
Weight Ratio ◽  
Silk Fiber ◽  
Bone Tissue Regeneration ◽  
Natural Silk ◽  
Green Processing ◽  
Gbr Membrane

Abstract Natural silk fiber (SF) was introduced into the chitosan/nano-hydroxyapatite (CS/n-HA) system to fabricate a novel guided bone tissue regeneration (GBR) membrane. The effect of different treatment methods (degummed, un-degummed, or dissolved SF) and different contents of SF on the properties of the CS/n-HA composite membrane was investigated. Results demonstrated that the degummed SF/CS/n-HA composite membrane with a weight ratio of 2:6:2 possessed the highest mechanical strength, where SF supported the composite membrane as a skeleton frame in the form of primeval state, while the un-degummed SF and dissolved SF had weaker reinforce effect due to the poor interface or poor interaction between SF and CS, and the dissolved SF/CS/n-HA composite membrane displayed the fastest degradation. However, the three SF could all improve the cell biocompatibility of the CS/n-HA composite membrane. Conclusively, the study revealed that degummed SF could in situ reinforce the CS/n-HA composite membrane with a simple and green processing method, which would provide an important guidance significant to develop a novel GBR membrane.

3D-printed nanocomposite scaffolds with tunable magnesium ionic microenvironment induce in situ bone tissue regeneration

2019 ◽  
Vol 16 ◽  
pp. 493-507 ◽  
Author(s):  
Jie Shen ◽  
Wenhao Wang ◽  
Xinyun Zhai ◽  
Bo Chen ◽  
Wei Qiao ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
3D Printed ◽  
Nanocomposite Scaffolds

scholarly journals Magnetic Resonance Functional Nano-Hydroxyapatite Incorporated Poly(Caprolactone) Composite Scaffolds for In Situ Monitoring of Bone Tissue Regeneration by MRI

2014 ◽  
Vol 20 (19-20) ◽  
pp. 2783-2794 ◽  
Author(s):  
Nitya Ganesh ◽  
Anusha Ashokan ◽  
Ramiah Rajeshkannan ◽  
Krishnaprasad Chennazhi ◽  
Manzoor Koyakutty ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
In Situ Monitoring ◽  
Bone Tissue Regeneration ◽  
Composite Scaffolds ◽  
Poly Caprolactone

Lactoferrin in Bone Tissue Regeneration

2020 ◽  
Vol 27 (6) ◽  
pp. 838-853 ◽  
Author(s):  
Madalina Icriverzi ◽  
Valentina Dinca ◽  
Magdalena Moisei ◽  
Robert W. Evans ◽  
Mihaela Trif ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Cells ◽  
Bone Diseases ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Bone Tissue Regeneration ◽  
Bone Homeostasis ◽  
Active Compounds

: Among the multiple properties exhibited by lactoferrin (Lf), its involvement in bone regeneration processes is of great interest at the present time. A series of in vitro and in vivo studies have revealed the ability of Lf to promote survival, proliferation and differentiation of osteoblast cells and to inhibit bone resorption mediated by osteoclasts. Although the mechanism underlying the action of Lf in bone cells is still not fully elucidated, it has been shown that its mode of action leading to the survival of osteoblasts is complemented by its mitogenic effect. Activation of several signalling pathways and gene expression, in an LRPdependent or independent manner, has been identified. Unlike the effects on osteoblasts, the action on osteoclasts is different, with Lf leading to a total arrest of osteoclastogenesis. : Due to the positive effect of Lf on osteoblasts, the potential use of Lf alone or in combination with different biologically active compounds in bone tissue regeneration and the treatment of bone diseases is of great interest. Since the bioavailability of Lf in vivo is poor, a nanotechnology- based strategy to improve the biological properties of Lf was developed. The investigated formulations include incorporation of Lf into collagen membranes, gelatin hydrogel, liposomes, loading onto nanofibers, porous microspheres, or coating onto silica/titan based implants. Lf has also been coupled with other biologically active compounds such as biomimetic hydroxyapatite, in order to improve the efficacy of biomaterials used in the regulation of bone homeostasis. : This review aims to provide an up-to-date review of research on the involvement of Lf in bone growth and healing and on its use as a potential therapeutic factor in bone tissue regeneration.

Bifunctional hydrogel for potential vascularized bone tissue regeneration

2021 ◽  
pp. 112075
Author(s):  
Bipin Gaihre ◽  
Xifeng Liu ◽  
Linli Li ◽  
A. Lee Miller ◽  
Emily T. Camilleri ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Vascularized Bone
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